DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Lama5

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	XP_006500638.1	Gene:	Lama5 / 16776	MGIID:	105382	Length:	3745	Species:	Mus musculus

Alignment Length:	1943	Identity:	337/1943 - (17%)
Similarity:	586/1943 - (30%)	Gaps:	693/1943 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  3296 PSKPEGPIEVSDIHKEGCKLKWRKPKDDGGIPITGYVIEKMDTATGKWVPAGSVDPEKYDIEIKG 3360
            |.||.|    ..||.|.|         |..:.:   :::.::.| |..:||       ...:::|
Mouse  2156 PGKPGG----HGIHCEVC---------DHCVVL---LLDDLERA-GALLPA-------IREQLQG 2196

  Fly  3361 LDPNHRYQFRVKAVNEEGESEPLETESAITAKNPFDVSAPPG-----LPELEDWDEHHVKLKWEP 3420
            ::.:.....|:..:|            |..|.....:.:|||     ..:|:..::..:.|:.:
Mouse  2197 INASSAAWARLHRLN------------ASIADLQSKLRSPPGPRYQAAQQLQTLEQQSISLQQD- 2248

  Fly  3421 PIRDGGSPITNYIIEVMDKDSGEFVKAVETDSPVCKGVVKKLEEGQQYKFRVRAVNKA------- 3478
             ....||..|.     :...:|:.:...|:    ..|..:||.|.      ||||.:|
Mouse  2249 -TERLGSQATG-----VQGQAGQLLDTTES----TLGRAQKLLES------VRAVGRALNELASR 2297

  Fly  3479 ----GPSD---PS-EQTNWHVAK-PRFLKPHIDR-VNLKPVIVKTGLSISLDINIRGEPAPKVEW 3533
                .|.|   || ||..|.:|: .|.|.....| :..:..:.:..|:.:..:..|.:......|
Mouse  2298 MGQGSPGDALVPSGEQLRWALAEVERLLWDMRTRDLGAQGAVAEAELAEAQRLMARVQEQLTSFW 2362

  Fly  3534 FFNNSSVTSDEHSVKIDNVDYNTKFFVMRAQRSQSGKYIIKATNEVGEDEAELEVTVLGKPGKPK 3598
            ..|.|..|    .::.....|.:....:|...:|       |.|...|.|
Mouse  2363 EENQSLAT----HIRDQLAQYESGLMDLREALNQ-------AVNTTREAE--------------- 2401

  Fly  3599 GPLQVNDITKHSCK--LKWEKPDDDGGSPIDYYEIEKLDPHTGQWLPCGKSTEPEAKVI------ 3655
               ::|...:...|  |:|::......:.:                   |:|...|.:|
Mouse  2402 ---ELNSRNQERLKEALQWKQELSQDNATL-------------------KATLQAASLILGHVSE 2444

  Fly  3656 ---GLHEGKAYKFRVRAVNKEGESEDLETEKPIIAKNPYDEPDRPGKPEPTNWDKDFVDLAWDPP 3717
               |:.:.|               ||||.    :|.:                    :|.||
Mouse  2445 LLQGIDQAK---------------EDLEH----LAAS--------------------LDGAW--- 2467

  Fly  3718 KNDGGAPIQKYVIQMRDKSGRAWVDSATVPGDKCNGTVTGVEEGHEYEFRIVAVNKAGPSDPSDV 3782
                 .|:.|.:......|.:  ||            :....|.|..:...:|:|.:|
Mouse  2468 -----TPLLKRMQAFSPASSK--VD------------LVEAAEAHAQKLNQLAINLSG------- 2506

  Fly  3783 SKSVIA---KPRFLKPHIDRKNLQKKIMRSGQMLHIDALIKAEPPAKVTWTY------------- 3831
               :|.   :.||::..::..|....|:::.|... ||..:|...|..||..
Mouse  2507 ---IILGINQDRFIQRAVEASNAYSSILQAVQAAE-DAAGQALRQASRTWEMVVQRGLAAGARQL 2567

  Fly  3832 --NKTEIKTSDHIKIENEDYKTTFIMPKVKRADRGIYIVTA-KNDSGSDTVEVELEVLCKPSKPK 3893
              |.:.::.:    |.....:......:::.|...::.|.| ||...:...|.:..:....|:..
Mouse  2568 LANSSALEET----ILGHQGRLGLAQGRLQAAGIQLHNVWARKNQLAAQIQEAQAMLAMDTSETS 2628

  Fly  3894 GPLA-VSNVTAETL----HLKWEKPEDDGGDPIEQYLVERMDTETGRWVPVL----------TTK 3943
            ..:| ...|.||.|    |:              |..::.|.....||...|          ..:
Mouse  2629 EKIAHAKAVAAEALSTATHV--------------QSQLQGMQKNVERWQSQLGGLQGQDLSQVER 2679

  Fly  3944 TPEADVTGLTEG-KEYLFRVKAVNSEG---ESEPLVTDIPTKAKNPFDAADTPGKPQIVDWSGNH 4004
            ...:.|:.|.:. .:.|.::..:.:.|   .|..|..:|....|....|.....|.::.......
Mouse  2680 DASSSVSTLEKTLPQLLAKLSRLENRGVHNASLALSANIGRVRKLIAQARSAASKVKVSMKFNGR 2744

  Fly  4005 CDLKWRAPEDDGGASITGYIVER-------KDPNTGKWQKALETSTPD-------CKARVNDLIA 4055
            ..::.|.|.|  .|.:..|...:       ..|..||       :|.|       .:....|.:.
Mouse  2745 SGVRLRTPRD--LADLAAYTALKFHIQSPVPAPEPGK-------NTGDHFVLYMGSRQATGDYMG 2800

  Fly  4056 GNKYQFRIMAVNKAGKSKPSEPSDQMTAKDRFAPPKIDRT-NIKDITIKAGQHIRFDIKVSGEPP 4119
            .:....::..|.:.||:.|:..|......::||...|||| ....:::...:.:..:||.....|
Mouse  2801 VSLRNQKVHWVYRLGKAGPTTLSIDENIGEQFAAVSIDRTLQFGHMSVTVEKQMVHEIKGDTVAP 2865

  Fly  4120 ATKVWLHNKARLENDDSNYNIDMESYRTKLTVPISKRF--HSGKYTLKAENESGRDEASFE-VIV 4181
            .::..|:    |..||..:.:.  .|.:..|.|...||  :.|...::..||......:|| ..:
Mouse  2866 GSEGLLN----LHPDDFVFYVG--GYPSNFTPPEPLRFPGYLGCIEMETLNEEVVSLYNFEQTFM 2924

  Fly  4182 LDKPGPPEGPLRVTDVHKEGCKLK-----WNAPLDDGGLPIDHYIIEKMDVESGRWLPSGRFKES 4241
            ||           |.|.|...:.|     |   |.||.     |:       .|.......|::.
Mouse  2925 LD-----------TAVDKPCARSKATGDPW---LTDGS-----YL-------DGSGFARISFEKQ 2963

  Fly  4242 FAELNNLEP--------------SHEYKFRVLAVNTEG-------------ESEPLTGEQSVIAK 4279
            |:.....:.              ..|.:|..|||. ||             :::||...|::.|.
Mouse  2964 FSNTKRFDQELRLVSYNGIIFFLKQESQFLCLAVQ-EGTLVLFYDFGSGLKKADPLQPPQALTAA 3027

  Fly  4280 NPFDEPGKPGTPEAVDWDKDHVDLVWRPPINDGGSPITG--------YVVEKREKGTDKWIKGTE 4336
            :.....|:              .|....|....|.|:..        :::....|..
Mouse  3028 SKAVRQGR--------------GLGMGGPAEKFGFPVPATHPLQIQVFLLAGNRKRV-------- 3070

  Fly  4337 ITIPCLGEECKATVPTLNENCEYEFRVKAINAAGPGE----------PSDAS-KPIITKPRKLAP 4390
                 |....:|||.:::::...|..........|.|          ||..| :..|...:.|..
Mouse  3071 -----LVRVERATVFSVDQDNMLEMADAYYLGGVPPEQLPLSLRQLFPSGGSVRGCIKGIKALGK 3130

  Fly  4391 KIDRKNIRTYNFKSGEPI--------------FLDINISGEPAPDVTWNQNNKSVQTTSFSHIEN 4441
            .:|.|.:.|.....|...              ||.:.:     |||              :.|..
Mouse  3131 YVDLKRLNTTGISFGCTADLLVGRTMTFHGHGFLPLAL-----PDV--------------APITE 3176

  Fly  4442 LPYNTKYINNNPERKDTGLYKISAHNFYG-QDQVEFQINIITKPGKPEGPLEVSEVHKDGCKLKW 4505
            :.|                   |...|.| ||.     |::.....|:||.:|| :.:....|::
Mouse  3177 VVY-------------------SGFGFRGTQDN-----NLLYYRTSPDGPYQVS-LREGHVTLRF 3216

  Fly  4506 KKPKDD------GGEPVESYLVEKFDPDTGIWLPVGRSDGPEYNVDGLVPGHDYKFRVKAVNKEG 4564
            ...:.:      .|.|   :.|..:...||:||.|  .|..:     ||..|:....:..:..|.
Mouse  3217 MNQEVETQRVFADGAP---HYVAFYSNVTGVWLYV--DDQLQ-----LVKSHERTTPMLQLQPEE 3271

  Fly  4565 ESEPLETLGSIIAKDPF---------------------------------SVPTKPG-VPEPTDW 4595
            .|..|  ||.:.....|                                 ||...|. :.|.:..
Mouse  3272 PSRLL--LGGLPVSGTFHNFSGCISNVFVQRLRGPQRVFDLHQNMGSVNVSVGCTPAQLIETSRA 3334

  Fly  4596 TANKVELAWPEPASDGGSPIQGYIVEVKDKYSPLWEKALETNSPTPTATVQGLIEGNEYQFRVVA 4660
            ||.||.....:|:.|                       |...:|....|:|     :.|||
Mouse  3335 TAQKVSRRSRQPSQD-----------------------LACTTPWLPGTIQ-----DAYQF---- 3367

  Fly  4661 LNKGGLSEPSDPSKIFTAKPRYL-----APKIDRRNLRNITL-------SSGTALKLDANITGEP 4713
               ||            ..|.||     :|  ..||..::::       |.|..|. .|.::|.
Mouse  3368 ---GG------------PLPSYLQFVGISP--SHRNRLHLSMLVRPHAASQGLLLS-TAPMSGR- 3413

  Fly  4714 APKVEWKLSNYHLQSGKNVTIETPDYYTKLVIRPTQRSDSGEY--------------LVTATNTS 4764
            :|.:...|::.|.      ..:|.....:|.::..|.|.:|::              :|..:.|.
Mouse  3414 SPSLVLFLNHGHF------VAQTEGPGPRLQVQSRQHSRAGQWHRVSVRWGMQQIQLVVDGSQTW 3472

  Fly  4765 GKDSVLVNVVITDKPSPPN---GPLQIS--------DVHKEGCHLKWKRPSDDGGTPIEYFQIDK 4818
            .:.::...|...::|.|..   |.|..|        .|...||              ::..|:||
Mouse  3473 SQKALHHRVPRAERPQPYTLSVGGLPASSYSSKLPVSVGFSGC--------------LKKLQLDK 3523

  Fly  4819 LEPETGCWIPSCRSTEPQVDVT---------GL-SPGNE-------YKFRVSAVNAEGESQPLVG 4866
             .|        .|:....|.||         || .||:|       .|.::..|:.|.|.:||..
Mouse  3524 -RP--------LRTPTQMVGVTPCVSGPLEDGLFFPGSEGVVTLELPKAKMPYVSLELEMRPLAA 3579

  Fly  4867 DESIVARNPFDEPGKPENLKATDWDKDHVDLAWTPPLI--------------DGGSPISCYIIEK 4917
            ...|.                      |:..|...|.:              ||....|.::...
Mouse  3580 AGLIF----------------------HLGQALATPYMQLKVLTEQVLLQANDGAGEFSTWVTYP 3622

  Fly  4918 QDKYGKWERA------------LDVPADQCKATIPDLVEGQTYKFRVSAVNAAGTGEP 4963
            :...|:|.|.            :|..::.....:|:.:.|......:.::..:.|..|
Mouse  3623 KLCDGRWHRVAVIMGRDTLRLEVDTQSNHTTGRLPESLAGSPALLHLGSLPKSSTARP 3680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020	17/93 (18%)
		FN3	3400..3489	CDD:238020	25/108 (23%)
		I-set	3494..3590	CDD:254352	16/96 (17%)
		Ig	3516..3590	CDD:299845	12/73 (16%)
		FN3	3594..3682	CDD:238020	14/98 (14%)
		FN3	3694..3781	CDD:238020	13/86 (15%)
		I-set	3795..3885	CDD:254352	17/105 (16%)
		Ig	3813..3885	CDD:299845	14/87 (16%)
		FN3	3889..3980	CDD:238020	19/109 (17%)
		FN3	3990..4082	CDD:238020	17/105 (16%)
		I-set	4090..4181	CDD:254352	21/94 (22%)
		Ig	4108..4181	CDD:299845	17/75 (23%)
		FN3	4185..4271	CDD:238020	20/117 (17%)
		FN3	4285..4383	CDD:238020	16/116 (14%)
		Ig	4404..4480	CDD:299845	13/90 (14%)
		FN3	4484..4571	CDD:238020	21/92 (23%)
		FN3	4584..4677	CDD:238020	17/93 (18%)
		I-set	4685..4775	CDD:254352	19/110 (17%)
		Ig	4703..4775	CDD:299845	14/85 (16%)
		FN3	4779..4863	CDD:238020	25/111 (23%)
		FN3	4879..4970	CDD:238020	14/111 (13%)
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
Lama5	XP_006500638.1	Laminin_N	59..303	CDD:365840
		EGF_Lam	304..352	CDD:238012
		EGF_Lam	363..426	CDD:238012
		EGF_Lam	433..474	CDD:238012
		EGF_Lam	500..547	CDD:214543
		EGF_Lam	546..589	CDD:238012
		Laminin_EGF	593..640	CDD:365839
		Laminin_EGF	638..685	CDD:365839
		EGF_Lam	682..724	CDD:238012
		EGF_Lam	781..832	CDD:238012
		EGF_Lam	833..>872	CDD:238012
		Laminin_EGF	1443..1491	CDD:365839
		Laminin_EGF	1533..1584	CDD:365839
		Laminin_EGF	1582..1630	CDD:365839
		Laminin_B	1694..1830	CDD:365838
		EGF_Lam	1864..>1900	CDD:238012
		Laminin_EGF	1915..1968	CDD:365839
		EGF_Lam	1970..2023	CDD:238012
		EGF_Lam	2025..2069	CDD:214543
		EGF_Lam	2071..2117	CDD:238012
		Laminin_EGF	2119..>2147	CDD:365839
		Laminin_I	2194..2452	CDD:310534	57/334 (17%)
		DUF3584	<2355..>2618	CDD:378817	59/386 (15%)
		Laminin_II	2642..2764	CDD:368703	22/137 (16%)
		LamG	2783..2912	CDD:214598	27/134 (20%)
		LamG	2969..3130	CDD:214598	29/188 (15%)
		LamG	3182..3300	CDD:214598	29/135 (21%)
		LamG	3364..3522	CDD:238058	36/200 (18%)
		LamG	3569..3696	CDD:214598	19/134 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910