back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and Dyrk1a

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001106860.1	Gene:	Dyrk1a / 13548	MGIID:	1330299	Length:	763	Species:	Mus musculus

Alignment Length:	816	Identity:	160/816 - (19%)
Similarity:	271/816 - (33%)	Gaps:	269/816 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  7926 LIKTKESV------KKKPIERKWEIDANGRKLRGKA--DGPVKDYDSYVFDIYSKFVPQPVEISQ 7982
            ||||.:.:      |||...::.:.|.:..|...|.  ||    ||...:|...|        :.
Mouse   100 LIKTYKHINEVYYAKKKRRHQQGQGDDSSHKKERKVYNDG----YDDDNYDYIVK--------NG 152

  Fly  7983 QSVYDRYDILEEIGTGAFGVVHRCRERSTGNIFAAKFIPVSHSVEKDLIRREIDIMNQLHHQ--- 8044
            :...|||:|...||.|:||.|.:..:|......|.|           :|:.:...:||...:
Mouse   153 EKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIK-----------IIKNKKAFLNQAQIEVRL 206

  Fly  8045 -KLINLHDA------------FEDDDEMILILEFLSGG--ELFERITAEGYVMTEAEVINYMRQI 8094
             :|:|.||.            |...:.:.|:.|.||..  :|.......|..:....  .:.:|:
Mouse   207 LELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTR--KFAQQM 269

  Fly  8095 CEGIRHM--HEQNIIHLDIKPENI-MCQTRSSTNVKLIDFGLATRLDPNEVVKITTGTAEFAAPE 8156
            |..:..:  .|.:|||.|:||||| :|..:.|. :|::|||.:.:|.......|.  :..:.:||
Mouse   270 CTALLFLATPELSIIHCDLKPENILLCNPKRSA-IKIVDFGSSCQLGQRIYQYIQ--SRFYRSPE 331

  Fly  8157 IVNREPVGFYTDMWATGVLSYVLLSGLSPFAGDNDVQTLKNVKACDWDFDVESF----KYISEEA 8217
            ::...|.....|||:.|.:...:.:|...|:|.|:|..:..:        ||..    .:|.::|
Mouse   332 VLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKI--------VEVLGIPPAHILDQA 388

  Fly  8218 KDFIRKLLVRNKEKRMTAHECLLHPWLTGDHSAMKQEINRDRYLAYREKLRRKYEDFERFLLPIG 8282
                                                           .|.|:.:|.     ||.|
Mouse   389 -----------------------------------------------PKARKFFEK-----LPDG 401

  Fly  8283 RLSEYSSLRKLLMEKYKIHDAVFDRRQAAPRFVIRPSSQFCYEGQSVKFYCRCIAIATPTLTWSH 8347
            ..|         ::|.|  |.   :|:..|                            |.....|
Mouse   402 TWS---------LKKTK--DG---KREYKP----------------------------PGTRKLH 424

  Fly  8348 NNIELRQSVKFMKRYVGDDYYFIINRVKLDDRGEYIIRAENHYGSREEVVFLNVQPLPKEQPRYR 8412
            |.:.:.......:| .|:..:.:.:.:|..|   .|:|            .|:..|..:.||.|
Mouse   425 NILGVETGGPGGRR-AGESGHTVADYLKFKD---LILR------------MLDYDPKTRIQPYY- 472

  Fly  8413 TESTPVRRREPLPYTFWQEESE--TAPSFTFLLRPRVMQARD--TCKLLCCLSG--KPVPNVRWY 8471
                      .|.::|:::.::  |..|.:....|.:.|::.  |.......||  ....|
Mouse   473 ----------ALQHSFFKKTADEGTNTSNSVSTSPAMEQSQSSGTTSSTSSSSGGSSGTSN---- 523

  Fly  8472 KDGRELSKYEYAMTHSDG--VVTMEIIDCK----------PSDSGKYSCKA-----TNCHGTDET 8519
             .||..|...:...||.|  ...::.:||:          |:..|....:|     ...|...||
Mouse   524 -SGRARSDPTHQHRHSGGHFAAAVQAMDCETHSPQVRQQFPAPLGWSGTEAPTQVTVETHPVQET 587

  Fly  8520 DCVVIVEGEWVTPEQAQLAHNFLYSGDRKYI---------EQPIKPAPLPIVTSRQYTSSSVQNT 8575
            ..       .|.|:|..|.|:...|....:.         :|.:.....|.|.:....|||.|
Mouse   588 TF-------HVAPQQNALHHHHGNSSHHHHHHHHHHHHHGQQALGNRTRPRVYNSPTNSSSTQ-- 643

  Fly  8576 SEPQGDKVNVSNSNSSGISNKKKYASNSLQAPGSPSRSRSATKELILPPDDSLMCKPEFTKPLHD 8640
                 |.:.|.:|:.|..|......|:|..:..:.::...|.:                .:|:..
Mouse   644 -----DSMEVGHSHHSMTSLSSSTTSSSTSSSSTGNQGNQAYQ----------------NRPVAA 687

  Fly  8641 LTIHDGE----QLILTCY--------VKGDPEPQIS 8664
            .|:..|:    .:.||.|        :.|.|..|.|
Mouse   688 NTLDFGQNGAMDVNLTVYSNPRQETGIAGHPTYQFS 723

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.