DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and EGFLAM

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_001192230.1 Gene:EGFLAM / 133584 HGNCID:26810 Length:1017 Species:Homo sapiens


Alignment Length:1286 Identity:250/1286 - (19%)
Similarity:391/1286 - (30%) Gaps:492/1286 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  6360 GAPSQPTISAYTPNSANLEW----HPPDDCGGKPITGYIVERRERGGE---WIKCNNYP----TP 6413
            |.|....:.|....:.:::|    ||     |.||.||.|...|.|.:   ..:.::.|    .|
Human    36 GPPLDIKLGALNCTAFSIQWKMPRHP-----GSPILGYTVFYSEVGADKSLQEQLHSVPLSRDIP 95

  Fly  6414 NTSYTVSNLRDGARYEFRVLAVNEAGPGHPSKPSDPMTAEHQRYRPDPPEPPKPDRI--TRNGVT 6476
            .|...:.:|:.|..|...:.|.::||.|..|.|....|.......| |..|.:|..|  :.:.|.
Human    96 TTEEVIGDLKPGTEYRVSIAAYSQAGKGRLSSPRHVTTLSQDSCLP-PAAPQQPHVIVVSDSEVA 159

  Fly  6477 LSWRPPRTDGKSRIKGYYVE-MRPKNGKDWKTVND-IPINSTVYTVPSLKEGEEYSFRVVAENEV 6539
            |||:|..::|.:.|:.|.|| :||...|.|.:::: |.::|.|  :..|.....|.|.|.|.|..
Human   160 LSWKPGASEGSAPIQYYSVEFIRPDFDKKWTSIHERIQMDSMV--IKGLDPDTNYQFAVRAMNSH 222

  Fly  6540 GRSDPSKPSQPITI---EEQPN-----KPCMELGKVRDIVCRAG--DDFSIHVPYLAF-PKP--- 6590
            |.|..|.||..|..   ||..:     :...::|...|   ..|  ||..:.:.:... |.|   
Human   223 GPSPRSWPSDIIRTLCPEEAGSGRYGPRYITDMGAGED---DEGFEDDLDLDISFEEVKPLPATK 284

  Fly  6591 ---NAFWYSNDNMLDDNNR-VHKHLTDDAASVVVKNSKRADSGQYRLQLKNTSGFDTATINVRVL 6651
               ..|...:..|...|.: :.:.:...:||:.|..   .......:|.|..:|   ..|..|:.
Human   285 GGNKKFLVESKKMSISNPKTISRLIPPTSASLPVTT---VAPQPIPIQRKGKNG---VAIMSRLF 343

  Fly  6652 DRPSPPTRLRADEFSGDSLTLYWNPPNDDGGSAIQNYIIEKKEARSSTWSKVSSFCT-------- 6708
            |.|...|...||.|..:..|  |      |||..|           .|..|....|:        
Human   344 DMPCDETLCSADSFCVNDYT--W------GGSRCQ-----------CTLGKGGESCSEDIVIQYP 389

  Fly  6709 -------VPFVRIRN--LVLNKEYDFRVIA---------ENKYGQSDPANTSEPILARHPFDIPN 6755
                   |.|..::|  .......:||..|         ||::|:.|..:.:   :.|.......
Human   390 QFFGHSYVTFEPLKNSYQAFQITLEFRAEAEDGLLLYCGENEHGRGDFMSLA---IIRRSLQFRF 451

  Fly  6756 TPGIPHGIDSTEDSITIAWTKPK----------HDG---------GSPITGYIIEKRLLSDDKWT 6801
            ..|       |..:|.::.||.|          .||         |:|:||              
Human   452 NCG-------TGVAIIVSETKIKLGGWHTVMLYRDGLNGLLQLNNGTPVTG-------------- 495

  Fly  6802 KAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYSGSSDLIFCRRPPHAPKITSDLSIRDM 6866
                                            ..|..||               |||        
Human   496 --------------------------------QSQGQYS---------------KIT-------- 505

  Fly  6867 TVIAGDEFRITVPYHASPRPTASWSL------NGLE------VIPGERIKFDSNDYASMYYNKSA 6919
                   ||  .|.:....|:|.|.:      .|.:      .:.|.||     |.......|:.
Human   506 -------FR--TPLYLGGAPSAYWLVRATGTNRGFQGCVQSLAVNGRRI-----DMRPWPLGKAL 556

  Fly  6920 KRDETGSYTITLTNNKGSDTASCHVTVVDRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGSPITN 6984
                           .|:|...|...:.|         .|..|...|||.               
Human   557 ---------------SGADVGECSSGICD---------EASCIHGGTCTA--------------- 582

  Fly  6985 YVVEKLDNSGSWVKISSFV-------RNTH-YDVMGLE-PHYKYNFRVRAENQYGLSDPLDIIEP 7040
                        :|..|::       :..| .|...|. |.::.:.|..|...:          |
Human   583 ------------IKADSYICLCPLGFKGRHCEDAFTLTIPQFRESLRSYAATPW----------P 625

  Fly  7041 IVAKH-----QFTVPDEPGQPKVIDWDSGNVTLIWTRPLSDGGSRIQGYQIEYRDILNDSSWNAY 7100
            :..:|     :|.:...|        |||:..|:::   .|.||         :|.|:       
Human   626 LEPQHYLSFMEFEITFRP--------DSGDGVLLYS---YDTGS---------KDFLS------- 663

  Fly  7101 DYIIKDTKYQLYNLIN--GSEYEFRIKAKNAAGLSKPSSP-------SLRFKLKGKFTVPSPPGA 7156
                          ||  |...|||....:..|:.:...|       .||               
Human   664 --------------INLAGGHVEFRFDCGSGTGVLRSEDPLTLGNWHELR--------------- 699

  Fly  7157 PQVTRVGKNYVDLKWEKPLRDGGSRITGYIIERRDIGGAVWVKCNDYNVLDTEYTVMNLIEMGDY 7221
              |:|..||.: |:.:|.          .|:|....||...:|||      |:..:..:....|.
Human   700 --VSRTAKNGI-LQVDKQ----------KIVEGMAEGGFTQIKCN------TDIFIGGVPNYDDV 745

  Fly  7222 EFRVFAVNSAGRSEPSLCTMPIKVCEVLGGKKPDWITRLQDKVAPFGKDYT-------------- 7272
            :      .::|..:|            ..|.....|  |.|:......|:|              
Human   746 K------KNSGVLKP------------FSGSIQKII--LNDRTIHVKHDFTSGVNVENAAHPCVR 790

  Fly  7273 LQCAASGKPSPTARWLRNGKEIQMNGGRMTCDSKDGVFRLHISNVQTGDDGDYTC-----EAMNS 7332
            ..||..|...|.    :.|.:         ||...|...||...    :.|:| |     ||:..
Human   791 APCAHGGSCRPR----KEGYD---------CDCPLGFEGLHCQK----ECGNY-CLNTIIEAIEI 837

  Fly  7333 LGFVNTSGYLKIGSPPIINRCPSELKLPEGDNSKI-----------KIFYSGDQPLTVILKKNNE 7386
            ..|:..| ||...:|.|:.|.       .|..|.:           .:.:.||.|    ::.|::
Human   838 PQFIGRS-YLTYDNPDILKRV-------SGSRSNVFMRFKTTAKDGLLLWRGDSP----MRPNSD 890

  Fly  7387 VICDSNDDTHV--KVNIFDDYVAIYIRNIVKSDGGPYQIEFT--NESGSATGEFYVHITGMPSAP 7447
            .|.....|..:  ..|:.....:|.: |...:||..::::..  .:||..|.:.|...||     
Human   891 FISLGLRDGALVFSYNLGSGVASIMV-NGSFNDGRWHRVKAVRDGQSGKITVDDYGARTG----- 949

  Fly  7448 TGPMGISYINKNSCMLNWRPPSYDGGLK-----------------VSHYVI 7481
            ..|..:..:|.|..:       |.||:|                 :||:.:
Human   950 KSPGMMRQLNINGAL-------YVGGMKEIALHTNRQYMRGLVGCISHFTL 993

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020 26/101 (26%)
FN3 6470..6552 CDD:238020 29/85 (34%)
I-set 6564..6650 CDD:254352 17/95 (18%)
Ig_Titin_like 6577..6650 CDD:143225 13/80 (16%)
FN3 6654..6745 CDD:238020 24/116 (21%)
FN3 6754..6840 CDD:238020 13/104 (13%)
I-set 6855..6946 CDD:254352 18/102 (18%)
Ig 6874..6946 CDD:299845 15/83 (18%)
FN3 6950..7042 CDD:238020 14/100 (14%)
FN3 7050..7139 CDD:238020 18/97 (19%)
FN3 7151..7237 CDD:238020 16/85 (19%)
I-set 7254..7334 CDD:254352 20/98 (20%)
Ig 7272..7339 CDD:143165 17/85 (20%)
IG_like 7354..7440 CDD:214653 17/100 (17%)
Ig 7366..7440 CDD:299845 15/88 (17%)
FN3 7444..7531 CDD:238020 9/55 (16%)
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
EGFLAMNP_001192230.1 FN3 36..133 CDD:238020 26/101 (26%)
FN3 142..234 CDD:238020 32/93 (34%)
LamG 391..541 CDD:238058 36/237 (15%)
EGF_CA 560..602 CDD:238011 11/77 (14%)
LamG 618..765 CDD:238058 43/251 (17%)
EGF_CA <792..820 CDD:238011 10/40 (25%)
Laminin_G_2 868..993 CDD:280389 26/141 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0613
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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