DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and MYOM3

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_689585.3	Gene:	MYOM3 / 127294	HGNCID:	26679	Length:	1437	Species:	Homo sapiens

Alignment Length:	1749	Identity:	365/1749 - (20%)
Similarity:	569/1749 - (32%)	Gaps:	570/1749 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  5774 DWDRDHIDL-----------QWAVPKSDGGAPISEYIIQKKE-------KGSPYWTNVRHVPSNK 5820
            ||:|..|..           .|...:    ....|.:.:.||       :|..:|..:|.....:
Human   107 DWERTEIAFLQTHRLLRQRRDWKTLR----RRTEEKVQEAKELRELCYGRGPWFWIPLRSHAVWE 167

  Fly  5821 NTTTIPELTEGQEYEFRVIAVNQAGQSEPSEPSDMIMAKPRYLPPKIITPLNEVRIKCGLIFHTD 5885
            :||.:...|                          :.|.|   ||::....|:.||...| |...
Human   168 HTTVLLTCT--------------------------VQASP---PPQVTWYKNDTRIDPRL-FRAG 202

  Fly  5886 IHFIGEPAPEATWTLNSNPLLS--------NDRSTITSIGHHSVVHTVNCQRSDSGIYHLLLRNS 5942
            .:.|          .|:..|||        .|.:|.|       |...|.....|....:|:|..
Human   203 KYRI----------TNNYGLLSLEIRRCAIEDSATYT-------VRVKNAHGQASSFAKVLVRTY 250

  Fly  5943 SGIDEGSFELVVLDRP--GP--------------PEGPME----YEEITANSVTISWKPPKDNGG 5987
            .|.|.| |:..:..|.  ||              .:.|..    :.|...::.:|.|    ...|
Human   251 LGKDAG-FDSEIFKRSTFGPSVEFTSVLKPVFAREKEPFSLSCLFSEDVLDAESIQW----FRDG 310

  Fly  5988 SEISS-------YVIEKRDLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTMYELRVMAENLQGRSD 6045
            |.:.|       |...:..|.           ||..|...      || :|.:||        ..
Human   311 SLLRSSRRRKILYTDRQASLK-----------VSCTYKED------EG-LYMVRV--------PS 349

  Fly  6046 PL----TSDQPVVAKSQYTVPGAPGKP---ELTDSDKNHITIKWKQPISNGGSPIIGYDIERRDV 6103
            |.    .|...:|..::...|||||.|   ...|.:::.:.:.|..|....|:||..|.|||...
Human   350 PFGPREQSTYVLVRDAEAENPGAPGSPLNVRCLDVNRDCLILTWAPPSDTRGNPITAYTIERCQG 414

  Fly  6104 NTGRWIKINGQPVPTAEYQDDRVTSNHQYQYRISAVNAAGNGKTSEPSAIFNARPLREKPRFYFD 6168
            .:|.||..:..|..|.......:.....|::|:.|::..|   :|.||
Human   415 ESGEWIACHEAPGGTCRCPIQGLVEGQSYRFRVRAISRVG---SSVPS----------------- 459

  Fly  6169 GLIGKRIKVRAGEPVNLNIPISGAPTPTIEWKRGDLKLEEGKRISYETNSERTLFRIDDSNRRDS 6233
                     :|.|.|.:                ||          ::....:|....|..|:
Human   460 ---------KASELVVM----------------GD----------HDAARRKTEIPFDLGNK--- 486

  Fly  6234 GKYTVTAANEFGKDTADIEVIVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDITGYIIEF 6298
                :|.:.:..:||..|       ||||.. :..:|....::.|.|..|.....:.:| |.:|.
Human   487 ----ITISTDAFEDTVTI-------PSPPTN-VHASEIREAYVVLAWEEPSPRDRAPLT-YSLEK 538

  Fly  6299 TEFGVDDWKPVPGTCP--NTNFTVKNLVEGKKYVFRIRAENIYGASEALE-GKPVLAKSPFDPPG 6360
            :..|...|:.:....|  :..|.|.:|.:.|.||||:||.|.||.|:..| .:|:..:.|  |..
Human   539 SVIGSGTWEAISSESPVRSPRFAVLDLEKKKSYVFRVRAMNQYGLSDPSEPSEPIALRGP--PAT 601

  Fly  6361 APSQPTISAY--TPNSANLEWHPPDDCGGKPITGYIVERRERG-GEWIKCNNYPTPNTSYTVSNL 6422
            .|....:.|:  |..|.:|.|.|..|   ..:.||.:..|:.| .||...||.|...|.:||..|
Human   602 LPPPAQVQAFRDTQTSVSLTWDPVKD---PELLGYYIYSRKVGTSEWQTVNNKPIQGTRFTVPGL 663

  Fly  6423 RDGARYEFRVLAVNEAGPGHPSKPSDPMTAEHQRYRPDPPEPPKPDRITRNGVTLSWRPPRTDGK 6487
            |.|..|||.|.:|:|||.|..|..::|:..:.....|..|.........:|.:.:.|:||:..|.
Human   664 RTGKEYEFCVRSVSEAGVGESSAATEPIRVKQALATPSAPYGFALLNCGKNEMVIGWKPPKRRGG 728

  Fly  6488 SRIKGYYVEMRPKNGKDWKTVNDIPINSTVYTVPSLKEGEEYSFRVVAENEVGRSDPSKPSQPIT 6552
            .:|.||:::.......||..||..||.:.|..|..|.||..|.||..|.|..|..:.|.||....
Human   729 GKILGYFLDQHDSEELDWHAVNQQPIPTRVCKVSDLHEGHFYEFRARAANWAGVGELSAPSSLFE 793

  Fly  6553 IEEQPNKPCMELGKVRDIVCRAGDDFSIHVPYLAFPKPNAFWYSNDNMLDDNNRVHKHLTDDAAS 6617
            .:|                                      |
Human   794 CKE--------------------------------------W----------------------- 797

  Fly  6618 VVVKNSKRADSGQYRLQLKNTSGFDTATINVRVLDRPSPPTRLRADEFSGDSLTLYWNPPNDDGG 6682
                                            .:.:|.||..:||.|....||.|.|.||...|.
Human   798 --------------------------------TMPQPGPPYDVRASEVRATSLVLQWEPPLYMGA 830

  Fly  6683 SAIQNYIIEKKEARSSTWSKVSSFCTVP------FVRIRNLVLNKEYDFRVIAENKYGQSDPANT 6741
            ..:..|.:..:|..|..|..|:     |      .:|:.:|...|.|.|:|.|.|..|...|:..
Human   831 GPVTGYHVSFQEEGSEQWKPVT-----PGPISGTHLRVSDLQPGKSYVFQVQAMNSAGLGQPSMP 890

  Fly  6742 SEPILARHPFDIPNTPGIPHGIDSTEDSITIAWTKPKHDGGSPI------TGYIIEKRLLSDDKW 6800
            ::|:|..   |.|....|..|:|. |..|.:|:..|:....|..      .|.:..:|:..:||.
Human   891 TDPVLLE---DKPGAHEIEVGVDE-EGFIYLAFEAPEAPDSSEFQWSKDYKGPLDPQRVKIEDKV 951

  Fly  6801 TKAVHALCPDLSCKIPNLIENAEYEFRVAAVNAAGQSAYS-GSSDLIFCRRPPHAPK--ITSDLS 6862
            .|:...|      |.|.|.:...|...|...:....:::: ...:|...::..|..:  :...:|
Human   952 NKSKVIL------KEPGLEDLGTYSVIVTDADEDISASHTLTEEELEKLKKLSHEIRNPVIKLIS 1010

  Fly  6863 IRDMTVIAGDEFRITVPYH-ASPRPTASWSLNGLEVI--PGERIKFDSNDYASMYYNKSAKRDET 6924
            ..::.::...|.|:.:... .||........|..|:.  |..:|.||..........::...::.
Human  1011 GWNIDILERGEVRLWLEVEKLSPAAELHLIFNNKEIFSSPNRKINFDREKGLVEVIIQNLSEEDK 1075

  Fly  6925 GSYTITLTNNKGSDTASCHVTVVDRPLP---------------PQGPLNAYDITPDTCTLAWKTP 6974
            ||||..|.:.|..:..:  :|:||....               .|||   |...|    |.||..
Human  1076 GSYTAQLQDGKAKNQIT--LTLVDDDFDKLLRKADAKRRDWKRKQGP---YFERP----LQWKVT 1131

  Fly  6975 LDDGGSPITNYVVEKLDNSGSWVKISSFVRNTHYDVMGLEPHYKYNFRVRAENQYGLSDP----- 7034
            .|                  ..|:::..|.||.     .|..:::.|: |||...|..||
Human  1132 ED------------------CQVQLTCKVTNTK-----KETRFQWFFQ-RAEMPDGQYDPETGTG 1172

  Fly  7035 LDIIEPIVAK----HQFTVPDEPGQ-PKVIDWDSGNVTLIWTR-----PLSDGGSRIQGYQIEYR 7089
            |..||.:..|    ::..|.|:.|: ..::|.....:..|:|.     .||....:|||.:...|
Human  1173 LLCIEELSKKDKGIYRAMVSDDRGEDDTILDLTGDALDAIFTELGRIGALSATPLKIQGTEEGIR 1237

  Fly  7090 DILNDSSWNAYDYIIKDTKYQLYNLINGSEYEFRIKAKNAAGLSKPSSPSLRFKLKGKFTVPSPP 7154
                         |....||  ||:
Human  1238 -------------IFSKVKY--YNV---------------------------------------- 1247

  Fly  7155 GAPQVTRVGKNYVDLKW---EKPLRDGGSRITGYIIERRDIGGAVWVKCNDYNVLDTEYTVMNLI 7216
                      .|:...|   :|.|..|....||..::.      :|:     ::||.:.:
Human  1248 ----------EYMKTTWFHKDKRLESGDRIRTGTTLDE------IWL-----HILDPKDS----- 1286

  Fly  7217 EMGDYEFRVFAVNSAGRSEPSLCT--------------MPIKVCEVLGGKK-------PDWITRL 7260
            :.|.|...:    :||:....|.|              ..:|...::...:       ||..|.:
Human  1287 DKGKYTLEI----AAGKEVRQLSTDLSGQAFEDAMAEHQRLKTLAIIEKNRAKVVRGLPDVATIM 1347

  Fly  7261 QDKVAPFGKDYTLQCAASGKPSPTARWLRNGKEI--------QMNGGRMTCDSKDGVFRLHISNV 7317
            :||.      ..|.|..||.|:|...||:|.:.:        ::.|..:|         :.|..|
Human  1348 EDKT------LCLTCIVSGDPTPEISWLKNDQPVTFLDRYRMEVRGTEVT---------ITIEKV 1397

  Fly  7318 QTGDDGDYTCEAMNSLGFVNTSGYLKIGSPPIINRCPSELKLPEGDNSKIKIFYSGDQP 7376
            .:.|.|.|.....|           |.||              |.....|.:|..||:|
Human  1398 NSEDSGRYGVFVKN-----------KYGS--------------ETGQVTISVFKHGDEP 1431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352
		Ig	560..633	CDD:143165
		Ig	657..731	CDD:143165
		I-set	746..835	CDD:254352
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020	14/96 (15%)
I-set	5865..5954	CDD:254352	23/96 (24%)
Ig	5882..5954	CDD:299845	18/79 (23%)
FN3	5958..6049	CDD:238020	20/121 (17%)
FN3	6062..6153	CDD:238020	28/93 (30%)
I-set	6173..6255	CDD:254352	12/81 (15%)
Ig_Titin_like	6182..6255	CDD:143225	10/72 (14%)
FN3	6259..6350	CDD:238020	29/93 (31%)
FN3	6359..6451	CDD:238020	34/94 (36%)
FN3	6470..6552	CDD:238020	28/81 (35%)
I-set	6564..6650	CDD:254352	1/85 (1%)
Ig_Titin_like	6577..6650	CDD:143225	1/72 (1%)
FN3	6654..6745	CDD:238020	29/96 (30%)
FN3	6754..6840	CDD:238020	20/91 (22%)
I-set	6855..6946	CDD:254352	17/95 (18%)
Ig	6874..6946	CDD:299845	15/74 (20%)
FN3	6950..7042	CDD:238020	24/111 (22%)
FN3	7050..7139	CDD:238020	16/94 (17%)
FN3	7151..7237	CDD:238020	14/88 (16%)
I-set	7254..7334	CDD:254352	22/87 (25%)
Ig	7272..7339	CDD:143165	17/74 (23%)
IG_like	7354..7440	CDD:214653	6/23 (26%)
Ig	7366..7440	CDD:299845	5/11 (45%)
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
MYOM3	NP_689585.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49
		I-set	154..247	CDD:254352	25/139 (18%)
		Ig	171..244	CDD:143165	21/119 (18%)
		IG_like	278..362	CDD:214653	19/113 (17%)
		Ig	<291..355	CDD:299845	17/93 (18%)
		FN3	373..463	CDD:238020	26/118 (22%)
		FN3	501..593	CDD:238020	29/93 (31%)
		FN3	603..691	CDD:238020	33/90 (37%)
		FN3	700..790	CDD:238020	29/89 (33%)
		FN3	802..891	CDD:238020	29/93 (31%)
		IG_like	1125..1205	CDD:214653	25/107 (23%)
		Ig	1334..1424	CDD:299845	27/129 (21%)
		I-set	1341..1424	CDD:254352	27/122 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13817
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	2.100