DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and Alpk3

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:NP_473426.2 Gene:Alpk3 / 116904 MGIID:2151224 Length:1680 Species:Mus musculus


Alignment Length:1720 Identity:306/1720 - (17%)
Similarity:546/1720 - (31%) Gaps:569/1720 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   548 KPRIVSENNGKLVIMECKVKADPKPDVIWFRNG-EVIKESNKIKTFIEQRGDQYYIKLELLDPQL 611
            |.|.|||::.  |...|.|...|:|:|.|:::. |:.:.....|..|..:|:::  .|:|...|.
Mouse    84 KSRAVSEDSD--VRFTCIVTGYPEPEVTWYKDDIELDRYCGLPKYEITHQGNRH--TLQLYRCQE 144

  Fly   612 EDSGLYKCNIKNTLGELNANLTLNIEIVPVIKDKPKIIKIIKKRTVVIECTVASKFEPKCTWY-- 674
            ||:.:|:.:.:||.|.::.:..|.:..:...|...:....:|::      ..|...|.:.:|.  
Mouse   145 EDAAIYQASARNTKGIVSCSGVLEVGTMTEYKIHQRWFAKLKRK------AAAKMREIEQSWKHG 203

  Fly   675 KETSTVKES------------KRHVYQVEQTKEGEFAVKLEINDVEESDKGAYK----------- 716
            ||.|...::            ||.:..||     |..:...:.::||....|::           
Mouse   204 KEASGEADTLLRKISPDRFQRKRRLSGVE-----EAVLSTPVREMEEGSSAAWQEGETESAQHPG 263

  Fly   717 --LVASNEKGEA------------------VSQIVNLVDIPEEERKPCKPEISRKLADQKVAESK 761
              |:.|...|||                  ::.|..::::..:...|.:....:|..|:   |||
Mouse   264 LGLINSFAPGEAPTNGEPAPENGEDEERGLLTYICEVMELGPQNSPPKESGAKKKRKDE---ESK 325

  Fly   762 TFELLVSLSQTDRKCKVEWYKGSTVIRETKDITTTFDGTTARLTFSSARTEHTSNYKVIVTNEVG 826
            ..|         :|.::|..:||..  .::::..:.|..      :|:|.|.:::.:...|...|
Mouse   326 PGE---------QKLELEKAEGSQC--SSENVVPSTDKP------NSSRREKSTDTQPAQTQPRG 373

  Fly   827 K------DESSCK-ITVEKVAKKKEEKPKE-----------------------KEKTKNEKEVEQ 861
            :      .||:.| .:|..:..|.::.|..                       ..::..:.....
Mouse   374 RVARGPGIESTRKTASVLGIQDKVQDVPAPAPAPVPAPALAPAPVPVPAPTPVPSRSSEQVYFSL 438

  Fly   862 KEM-----------EEDK---------NESGQSVAQTEGRI-NIEQISE---------------- 889
            |:|           ||:|         .||.......:.|: .:..:|.                
Mouse   439 KDMFMETTRAGRSQEEEKPPPPSTRVAGESPPGKTPVKSRLEKVPMVSSQPTSSMVPPPIKPLNR 503

  Fly   890 ---GDPKEELTVKEEILDKRDTQEVKESSVELQDSAGHEVPEP----KKATSDSKLDQSNQ---- 943
               ..||.::......|..:.::.:.:|..:...||..:||.|    :..|.||.|.....    
Mouse   504 KRFAPPKSKVESTTTSLSSQTSESMAQSLGKALPSASTQVPTPPARRRHGTRDSPLQGQTSHKTP 568

  Fly   944 -------------KNLDKKHKTDQSESKTNKNVSLAEPIKSNKQE---------SEEQQATEQIG 986
                         |:.:....|...:..::.|....||:.:..||         :..::.|...|
Mouse   569 GEALESPATVAPTKSANSSSDTVSVDHDSSGNQGATEPMDTETQEDGRTLVDGRTGSRKKTHTDG 633

  Fly   987 LKKVDRKASIVSVKEEISSDVRRKSTIKAKEE-ITVDDKKASSRRSS------------------ 1032
            ..:||.:......::...:..|.::..||..: :|...::..|.|||                  
Mouse   634 KLQVDGRTQGDGAQDRAHASPRTQAGEKAPTDVVTQGSERPQSDRSSWKNLVTQRRVDMQVGQMQ 698

  Fly  1033 -------------LAVEESNTESRRSSI-------IDKKPLEQVDNKPIDANKNPQPLKEEIPRL 1077
                         :..||..|:|...||       .::..:..:.:.|.....:|.....|...:
Mouse   699 AGERWQQDPGDARIQEEEKETQSAAGSIPVAFETQSEQLSMASLSSLPGALKGSPSGCPRESQAI 763

  Fly  1078 KPAEKRRTSKVIEEPK--------------------------------PDEGLPK---------- 1100
            :..||...:..::|..                                |.||..:          
Mouse   764 ECFEKSTEAPCVQERSDLMLRSEEAAFRSHEDGLLGPPSGNRTYPTQLPPEGHSEHLGGQTHQRS 828

  Fly  1101 LRKASIAQV--KEEAK-------------------PAAPKLKAKAKAKPKYEELP---------- 1134
            .::.|::|.  ||:.:                   ||.|.|..........||||          
Mouse   829 EQEDSLSQCPKKEQPQEPLHVGLSGGHSTGLSQEVPAMPSLPGTGLTSSLQEELPGTAASLHTNT 893

  Fly  1135 EIPDYERPQLEKYEKSDFTPSDFARDLEI----------PNKMEKPIIDSGKKEPAVLAQKNGI- 1188
            ::|...|.|       ||..|  |..|::          |..|......:..|||.|..:.:|. 
Mouse   894 DVPLPSRDQ-------DFPSS--APTLQLGPGSPTQSHPPEAMATSSEGACAKEPNVDGRSSGTR 949

  Fly  1189 ---PKKTDIIEQYADEPKGLKVGKGKLPDEGDGR--------DGAVLKPVIIEPEKEILDLGNKK 1242
               |...|.::.|.     |.:.|...|:..:.|        .|.:.....:.|..|:..|..:.
Mouse   950 SCDPGLIDSLKNYL-----LLLLKLSSPETSEARAESQEVADTGGLTSSSTLVPTMEVAGLSPRT 1009

  Fly  1243 NNQHADKPTVLDIIKQRRRSSIRNLMTKEPIQNESFLGVVLKPVIKDTREQAAPQQAIQLTKANA 1307
            :.:      :|:.::..........:...|..:....|::       .||..|.|||  |..|..
Mouse  1010 SRR------ILERVENNHLVQSAQTLLLSPCTSRRLTGLL-------DREVQAGQQA--LAAAQC 1059

  Fly  1308 TEQFSPTKAVKAQVADLKKPETLATL---------EDNYERPVLEKYDPFSIDKTKSEKSTPSII 1363
            :....||            |.|:..:         ||:.||              .|::|....:
Mouse  1060 SRGPCPT------------PLTIPAIVVGEEGSAGEDSEER--------------TSQESDKKGL 1098

  Fly  1364 TPDIRGPEVKLPVQE------------------TKEE-------KQKVPKMQPPAPGDPPKIEVI 1403
            ..::.|..|:...||                  |.||       |:.:||::..:.|:..|.|  
Mouse  1099 LGEVEGHTVESRTQEPCQEEAMPGEALTGLPAATPEELALGARRKRFLPKVRAGSDGEANKAE-- 1161

  Fly  1404 REKRPSLAPEPPSRRGSLIP--PADTGRRPSLIINDEKKLRPGEVMDTRLLR-PGEVGE------ 1459
            ..:.|:::|..| |:| |.|  |...||         ::..|.:.....:|. ||...|      
Mouse  1162 ERESPTVSPRGP-RKG-LTPGSPGTPGR---------ERRSPTQARKASMLEVPGAEEEPATGDL 1215

  Fly  1460 -------GQRRRPSIDVRRPSV----QDLEDLINKPSTPLRDVGDGGPPSIVDVQ---ESYSVVE 1510
                   |....|::|..:...    :..:||:..|....:...:..|.|...::   :.:::|.
Mouse  1216 VSRSKDSGLDSEPAVDEGKQEALAKQRKAKDLLKAPQVIRKIRVEQFPDSSGSLKLWCQFFNIVS 1280

  Fly  1511 DSTAYLTVGVEGSPAPTFKFYKGVSEILEGGRFKFLTDGQTNTITLCMRKCKPNDESKYKIVVSN 1575
            ||.  ||...:..|         |.|:....       |......|.:.:..|.|...|:..:.|
Mouse  1281 DSV--LTWAKDQHP---------VGEVNRSA-------GDEGPAALAIVQASPTDCGVYRCTIQN 1327

  Fly  1576 IHGEDSAEMQLYVSDSSGMDFRAMLKKRRYQKWDKDEQDPN-----------WGD-------LKE 1622
            .||..|.:..|.....||     .:.:...:..::.|..|.           |||       .:|
Mouse  1328 EHGSASTDFCLSPEVLSG-----FISREEGEVGEEIEMTPMVFAKGLADSGCWGDKLFGRLVSEE 1387

  Fly  1623 TEKPLPALKKVER-KVESFLSPLIDQFAKEGKDKKVVFEARFSKPNCKPKWLFRKDEVFTGSKFK 1686
            .......|:|..| ||...|.|              :||   |...|..|         ..|...
Mouse  1388 LRGGGHGLQKASRAKVIYGLEP--------------IFE---SGRTCIIK---------VSSLLV 1426

  Fly  1687 FKQENDT------YQLIITTPKVEDTGKYTIEIGGVSSTA---FLNVEEADPTYTFTKP------ 1736
            |...::|      |.:.|...|:::..:...:|....:.|   |..|.|..|.|...:|      
Mouse  1427 FGPSSETSLLGRNYDVTIQGCKIQNMSREYCKIFAAEARAASGFGEVPEIIPLYLIYRPANNIPY 1491

  Fly  1737 ------LKKKLEGFTQHE---TTLECSVSSSMA------NVHWFKNNTKLESDDPRYLISKDING 1786
                  |.|.|:.:...:   .....:.|||.|      ..||....|     :..:|:: |:.|
Mouse  1492 ATLEEDLGKPLQTYCSRQWGCAGAPAAASSSEALQKCQTFQHWLYQWT-----NGSFLVT-DLTG 1550

  Fly  1787 NLKLIIKDSVLDDAGLYRCQLDKQPDKTECNLKVTEYPYKFVKVLKSQQCIEKDTVTLACEIDDA 1851
                  .|..:.|..:.......|..|..|      :|....:...|.||      ...|   |.
Mouse  1551 ------ADWKMTDVQIATKLRGYQGLKESC------FPALLDQFASSHQC------NTYC---DM 1594

  Fly  1852 MGEVQWLRNGEEIKPDKRIQIVKD---GRK 1878
            :| ::.|:..|...|..:.:..|.   |||
Mouse  1595 LG-LKPLKGPEAAHPQAKAKGSKSPSAGRK 1623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352 26/88 (30%)
Ig 560..633 CDD:143165 20/73 (27%)
Ig 657..731 CDD:143165 19/118 (16%)
I-set 746..835 CDD:254352 19/95 (20%)
Ig 1496..1586 CDD:299845 19/92 (21%)
IG_like 1503..1588 CDD:214653 18/87 (21%)
I-set 1639..1724 CDD:254352 16/93 (17%)
IG 1750..1821 CDD:214652 15/76 (20%)
IGc2 1750..1806 CDD:197706 12/61 (20%)
I-set 1826..1909 CDD:254352 13/56 (23%)
Ig 1831..1897 CDD:299845 13/51 (25%)
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
Alpk3NP_473426.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
I-set 77..169 CDD:254352 26/88 (30%)
IGc2 90..159 CDD:197706 20/72 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 238..288 8/49 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 785..951 30/174 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1078..1128 10/63 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1147..1244 23/109 (21%)
Ig <1285..1330 CDD:299845 10/60 (17%)
Alpha_kinase 1372..1592 CDD:214828 52/269 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1603..1680 6/21 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847411
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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