DRSC/TRiP Functional Genomics Resources

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Protein Alignment bt and igfn1.3

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:XP_005168832.1 Gene:igfn1.3 / 100331959 ZFINID:ZDB-GENE-131122-44 Length:1355 Species:Danio rerio


Alignment Length:1991 Identity:397/1991 - (19%)
Similarity:647/1991 - (32%) Gaps:714/1991 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1378 ETKEEKQKVPKMQPPAPGDPPKIEVIREKRPSLAPEPPSRRGSLIPPADTGRRPSLIINDEKKLR 1442
            ::|||       :|.|||     :|..:||..:                                
Zfish     5 KSKEE-------EPTAPG-----QVAIKKRSKV-------------------------------- 25

  Fly  1443 PGEVMDTRLLRPGEVGEGQ---RRRP-SIDVRRPSVQDLEDLINKPSTP----LRDVGDGGPPSI 1499
            || ||.|:.::....|:..   .|:| ::.::.......:.::....||    .|:.||...|..
Zfish    26 PG-VMITQFVQEIPAGKSHPDFSRKPIALTIQEGKFAFFKAIVTGDPTPTVTWARNNGDTSNPER 89

  Fly  1500 VDVQESYSVVEDSTAYLTVGVEGSPAPTFKFYKG----------VSEILEGG------------- 1541
            ..|.....:.|.......|||:  .|.|:|.:..          ...::|.|             
Zfish    90 YIVSYDPILGEHQLQMPNVGVD--QADTYKCFASNEYGRAVVTVTLNVIEVGFKKSKAMQDSRIE 152

  Fly  1542 -RFKFLTDGQTNTITLCMRKCKPN----DESKYKIVVSNIHGEDSAEMQLYVSDSSGMDFRAMLK 1601
             |.|...|.:.|..|...:|.|..    ||..:::::|    .|..:.:...::....|||.||:
Zfish   153 QREKAAADLKKNLRTRAEQKEKKKDGEVDEKFWELLLS----ADKKDYERICAEYGVTDFRWMLR 213

  Fly  1602 KRRYQKWDKDEQDPNW----GDLKETEKPLPALKKVERKVESFLSPLIDQFAKEGKDKKVVFEAR 1662
            |...:|.:.:||...:    .:||..|...|...:.|                        ||..
Zfish   214 KLNEKKREIEEQQSQYIEHLSNLKHIEVKTPGCAEFE------------------------FEMD 254

  Fly  1663 FSKPNCKPKWLFRKDEVF------TGSKFKFKQENDTYQLIITTPKVEDTGKYTIEIGGVSSTAF 1721
            ...||.| .:|| ||.|.      |..|...:|....:...::....||.|.|.::|.||     
Zfish   255 LKDPNAK-IFLF-KDGVMVPFTFDTDEKHSLRQVGRKFIFSVSGLNPEDAGLYQVDIEGV----- 312

  Fly  1722 LNVEEAD---PTYTFTKPLKKKLEGFTQHETTLECSVSSSMANVHWFKNNTKLESDDPRYLISKD 1783
             ||...|   |...|...: ::::...:.:...||.:|:.:..:.|...|..||..: :|.||  
Zfish   313 -NVFSTDFKIPAADFLVKI-QEVKAIERQDAVFECLLSAPLPKISWLGKNVPLEHGE-KYDIS-- 372

  Fly  1784 INGNL---KLIIKDSVLDDAGLYRCQLDKQPDKTECNLKVTEYPYKFVKVLKSQQCIEKDTVTLA 1845
            ::.::   ||::||.:..|.|:|......:    .||                            
Zfish   373 VSEDMLIHKLVVKDCMQVDKGIYTAVAGMK----SCN---------------------------- 405

  Fly  1846 CEIDDAMGEVQWLRNGEEIKPDKRIQIVKDGRKRKLVIKDCKVTDAGQFKCTTNADTTESEIIIN 1910
                      .||....:..|::|      |:|   .::  |.|.||    ...||..:   |..
Zfish   406 ----------AWLIVEADPDPNQR------GKK---AVR--KTTQAG----GGGADLMK---IAA 442

  Fly  1911 YQNRFNKKLKDTEAVEREKLILDIELQDQTAPCDWK-FNGEPIVPSESIEIKNMGGGKHQLIFSS 1974
            .|:...:|.:| |.:||.:.:..|:.:::.|..:.| ...:|..|.           .|:     
Zfish   443 EQSEKLQKERD-ERMERIEKMKQIQAEEEAAKEEEKPAEEQPAAPE-----------PHK----- 490

  Fly  1975 LDMSNEGEITCESGQLSSKCKLSIRKGESRPNIDCPDKFSGPISAPVLLEVPFKVSGTKQTPVEA 2039
                                    .|.:.:|......:..|||..|                   
Zfish   491 ------------------------PKPKPQPQPQIKQESEGPIEEP------------------- 512

  Fly  2040 KLFKDGKPLPVKDVEVAVTDDKVTFKIKKPSRDLSGPYQIKISNGQGEDTKDVQIICQDVPQPPQ 2104
                :.:|.|..:|           :.:||..:.:.|.|.:....:.|..|.|    :..|..|.
Zfish   513 ----EAEPKPEPEV-----------REEKPKTEEAAPPQAEEEPTKEEPRKRV----RTGPLVPD 558

  Fly  2105 DVDITDVYQTSCVVSFNPPSDDGGTPITKYVIERQDLSKKHGWESVAEVLPSEPCLKKIDDLIPK 2169
            .|....|:.||           |.:.:...:.:..::..|         |.||.|    |.:   
Zfish   559 TVIDPGVHFTS-----------GLSDVHAIIGQTAEMVCK---------LSSENC----DGI--- 596

  Fly  2170 KQYRFRIRAVNAIGQSDPATFKNTILAKDPWDEPGKPKAVDLTDWDKDHADLKWEAPETDGGDPI 2234
                                          |.:.|    :::|..|    |||            
Zfish   597 ------------------------------WYKDG----IEITATD----DLK------------ 611

  Fly  2235 TAYIVEYKEKFSNDWVSGKEVDGDARTATVDGLKEGQQYEFRVRAVNRAGPGEPSDKTKSIIA-- 2297
               ||:               ||......|....|....::|..|..|        ||::|:.  
Zfish   612 ---IVK---------------DGAVHKIVVSNCTEDDNGKYRFEADGR--------KTEAILVVE 650

  Fly  2298 ---------KCRFVKPFIVGEGLKNVTVKKGQTIRFDIKYDGEPEPAATWVKGTDNLKFDNQRIC 2353
                     ..:|.:|         |.:|.||...|.:::.|.......|.:..:.:..|| .|.
Zfish   651 DPPRINLEDLAKFSEP---------VIIKVGQNATFKLEFVGREPMKIQWYQEGEEMLEDN-HIK 705

  Fly  2354 LDQLERNSSITIKKSVRKDTGKYKLVLSNSSGTIESEAQVVVLDRPLPPGGPFEPEEIRASHIKM 2418
            :::...:|.:.:.|..|||:|:.||.|.|..||||:.::::|:|:|..|.||.:..|..:|.::.
Zfish   706 IERSSIHSRLLLVKCQRKDSGEIKLKLKNEFGTIEARSKLIVIDKPTNPMGPVDVIEASSSCVEF 770

  Fly  2419 KWKRPDDDGGCEISGYALERMDEETGRWIPAGEVGPNETSFDFKGLTPNKKYKFRVKAINKEGES 2483
            ||:.|.||||..|..|.|||.......|:..|.: |.|..:....:...:||.:|::|:..||.|
Zfish   771 KWRPPKDDGGSPIINYYLERNQIGRNTWMKIGNI-PGEPHYKDNDVDHGRKYCYRIRALTAEGTS 834

  Fly  2484 EPLETFDAIVARNPYDPPSPPSQPVIDDYDNKSVLLKWKRPPSDGGRPITHYIVEIKDKFAPSWS 2548
            :..||.|.......|  |..||.|.:.......:.|.|..|.:.||..|..|.:|.:.:.:..|.
Zfish   835 DVYETSDIQAGTKAY--PGQPSTPKVVSAFKNCITLAWTPPTNTGGTNIVGYNMEKRKRGSNLWG 897

  Fly  2549 EVAKTDDP--NPECNVEGLKEKMVYQFRVRAVNKAGPSEPSQPTDNHLCKHKNLKPQIDRSTFKR 2611
            :|...::|  ..:.:|:.:.|.|.|:|||.|:|.:|..|||.|:                     
Zfish   898 QVNPPEEPIKGKQYDVKDVVEGMEYEFRVSAINFSGAGEPSAPS--------------------- 941

  Fly  2612 VTIKSGRTHKWSVDVLGEPIPELHWSWRDDIPLTNGDRIKIENVDYHTDFSITNVLRKDSGFYTL 2676
                                                                             
Zfish   942 ----------------------------------------------------------------- 941

  Fly  2677 KAENRNGIDRETVELVVLGKPSSPKG---PLAVSDVTASGCKLQWKKPEDDGGV--PIKEYVVEK 2736
                         |.|:...|..|.|   .|.|:|.|.|...|.|.||:::.||  ..|.|.||.
Zfish   942 -------------EFVIARDPKKPPGKVIDLKVTDSTYSSLSLSWTKPKEEKGVQDEAKGYFVEL 993

  Fly  2737 MDTATGKWVRVGRSPGEKEPPSFDVTGLSLGSEYMFRVSAVNEEGESEPLTTLVGVVAKDPFDEP 2801
            ....:..|.|...:|  ....|:.:.||...:.|..||.|.||.|:.||                
Zfish   994 RPAESIDWGRCNSNP--LITASYTILGLKSMAMYWVRVVATNEGGDGEP---------------- 1040

  Fly  2802 NKPGTPEVTDYDNQSISLKWAAPNNDGGAPIQKYIIEKKNKNKTEWEKALEIPGDQLEATVAGLQ 2866
                    .|.||                    |||                             
Zfish  1041 --------KDLDN--------------------YII----------------------------- 1048

  Fly  2867 EYGEYQFRVIAVNKAGLSPPSDASVPQIVKYKKLKPRIDRSNLKP-LLIRAGKPIRYDVNVRGEP 2930
                           .:.||             ::|......:|. :::||....|.::|....|
Zfish  1049 ---------------AMPPP-------------VRPNFTNRKMKSFMVVRAENSARVNINFEASP 1085

  Fly  2931 APVITWYQNDKELKPEELPSSS--EIKNIPYNTKISIIETVRKHTGIYKIIAVNEHGQDEATVEV 2993
            .|.|.|.:       :.:|.|.  .|.|....:::.|....|..:|||.|...|..||:..:||:
Zfish  1086 TPTIIWLK-------DGMPVSKRVNISNADGMSQLLIASAERSDSGIYSITVKNMVGQETFSVEI 1143

  Fly  2994 NILAPPSKPRGPLDVKDVTKDSCKLKWKKPEDDGGKPISAYQVEKFDKKQGRWVPLGRTSANDTE 3058
            .:...| ||.||:::::....:..:.|:...|:.......|.|.|.|..:..|..:.....|: .
Zfish  1144 RVTDDP-KPPGPVELEENVPGTLTVSWEPSSDEKRDNHLHYMVMKRDSVKRTWQTVADRLFNN-N 1206

  Fly  3059 FDVKGLQEGHEYQFRVKAINEEGESDPLDSDDSIIAKNPYDAASKPGTPNIVDYNEHMVKLKWEA 3123
            |....:..|.||:|||.|.|:.|.|:|.:|                              |||. 
Zfish  1207 FTAVNITPGREYKFRVYAKNDIGLSEPSES------------------------------LKWG- 1240

  Fly  3124 PRSDGGAPISGYIIEKKDKFSPIWDEILSTNTSVPEATVEGLVEGNIYQFRVRAVNKAGFSDPSD 3188
                        :::|::||      ||:...|.|                      ..|....:
Zfish  1241 ------------VVKKREKF------ILNLPPSKP----------------------CNFDSAPN 1265

  Fly  3189 ATEPHLAKPRNLKPYINRDKMKPIKVRAGQPVKFDVDVKGEPAPSLTWFLKETELTSTGQVRLEN 3253
            .|.|       ||.:...:|.:         ......|||.|.|.:||:.....|.:.....:.|
Zfish  1266 FTVP-------LKMHTTPEKYE---------CYMSCAVKGNPKPHVTWYRNNISLNTNTNYYISN 1314

  Fly  3254 IDYNTKLTLLDTDRKQSGQYKLRAENINGVDEAVVEVIILD 3294
            ......:.:|....|.:|:||:.|||..|..|...::.||:
Zfish  1315 TCGVCSMLILRVSAKDNGEYKVVAENSVGRAECSTQLTILE 1355

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352
Ig 136..209 CDD:143165
I-set 228..320 CDD:254352
IGc2 242..312 CDD:197706
I-set 335..425 CDD:254352
Ig 350..423 CDD:143165
Ig 436..530 CDD:299845
I-set 438..532 CDD:254352
I-set 545..636 CDD:254352
Ig 560..633 CDD:143165
Ig 657..731 CDD:143165
I-set 746..835 CDD:254352
Ig 1496..1586 CDD:299845 22/117 (19%)
IG_like 1503..1588 CDD:214653 20/112 (18%)
I-set 1639..1724 CDD:254352 20/90 (22%)
IG 1750..1821 CDD:214652 19/73 (26%)
IGc2 1750..1806 CDD:197706 17/58 (29%)
I-set 1826..1909 CDD:254352 12/82 (15%)
Ig 1831..1897 CDD:299845 10/65 (15%)
I-set 1914..1998 CDD:254352 11/84 (13%)
Ig 2020..2095 CDD:299845 11/74 (15%)
FN3 2100..2194 CDD:238020 13/93 (14%)
FN3 2203..2292 CDD:238020 15/88 (17%)
I-set 2311..2395 CDD:254352 24/83 (29%)
Ig 2321..2395 CDD:299845 20/73 (27%)
FN3 2399..2493 CDD:238020 32/93 (34%)
FN3 2501..2590 CDD:238020 28/90 (31%)
I-set 2602..2693 CDD:254352 1/90 (1%)
Ig 2619..2693 CDD:299845 1/73 (1%)
FN3 2697..2793 CDD:238020 33/100 (33%)
FN3 2801..2893 CDD:238020 8/91 (9%)
I-set 2902..2995 CDD:254352 25/95 (26%)
Ig 2919..2993 CDD:299845 20/75 (27%)
FN3 2999..3088 CDD:238020 25/88 (28%)
FN3 3102..3191 CDD:238020 11/88 (13%)
I-set 3208..3292 CDD:254352 20/83 (24%)
Ig 3219..3292 CDD:299845 19/72 (26%)
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
igfn1.3XP_005168832.1 I-set 44..135 CDD:254352 16/92 (17%)
I-set 326..410 CDD:333254 22/129 (17%)
I-set 566..638 CDD:333254 23/166 (14%)
I-set 662..747 CDD:333254 26/94 (28%)
FN3 751..834 CDD:214495 28/83 (34%)
FN3 850..944 CDD:238020 30/192 (16%)
FN3 953..1040 CDD:238020 29/88 (33%)
Ig 1076..1145 CDD:325142 21/75 (28%)
FN3 1149..1236 CDD:238020 25/88 (28%)
I-set 1264..1353 CDD:254352 24/104 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 62 1.000 Domainoid score I10301
eggNOG 1 0.900 - - E1_KOG0613
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR13817
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
33.000

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