DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and palld

DIOPT Version :10

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:XP_017951326.2 Gene:palld / 100144658 XenbaseID:XB-GENE-854910 Length:1668 Species:Xenopus tropicalis


Alignment Length:1475 Identity:257/1475 - (17%)
Similarity:456/1475 - (30%) Gaps:574/1475 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly  7636 AVKIIDPQAASPPLIVKPLRDANCIQNHNAQFTCTINGVPKPTISWYKGAREISNGARYHMYSEG 7700
            |.|.::|.||:  ..::.||.....:....:..|...|.|.|.|.|:...:|:||....|:.|:.
 Frog   524 ANKSVNPPAAA--RFIQKLRSQEVAEGSRVKLECRATGNPLPEIRWFCEGKELSNSPDIHISSDS 586

  Fly  7701 DN-HFLNINDVFGEDADEYVCRAVN------------------------------KAGA------ 7728
            :. |.|.|.:.|.||...|.|.|.|                              |.||      
 Frog   587 NGLHTLVIAEAFEEDTGRYTCVASNCLGSDTSSAEIFVEGASSSDSESESFAFKSKQGAMPQAQK 651

  Fly  7729 KSTRATLAI-MTAPK----------LNVP------------------PRFRDTAY--------FD 7756
            |::..:|.| .::||          :::|                  |.|...|:        ..
 Frog   652 KTSSVSLTIGPSSPKCGITTAVMQPISIPVQQVRSPTSYLYQDRSKTPTFCAPAFTKELQNLTAS 716

  Fly  7757 KGENVVIKIPFTGFPKPRIHWVRDGENIESGGHYTVEVK--------ERHAVLIIRDGSHLDSGP 7813
            :|:.||::....|.|..::.|.|.|..|:....:.:..|        |....|:|.:....|:|.
 Frog   717 EGQVVVLECRVKGTPPVKVKWFRQGSEIQDSPDFRILQKKPRCASEPEEICTLVIAETFPEDAGI 781

  Fly  7814 YRITAENELGSDTAIIQVQI-SDRPDPPRFPLIESIGTESLSLSWKAPVWDGCSDITNYYVERRE 7877
            :..||.|:.||.:...|:.: |......|    .::.:|.:|                .|..::.
 Frog   782 FTCTARNDYGSVSCSAQLTVLSANNTHTR----NNVSSEEIS----------------GYDSQKP 826

  Fly  7878 HPLSSWIRVGNTRFTSMAVSGLTPGKEYDFRIFADNVYGRSDASDTSTLIKTKESVKKKPIERKW 7942
            .|||:   |.|:....|:                        :...|...:|.::..:..:|:..
 Frog   827 SPLSA---VPNSSCLEMS------------------------SKKNSECFQTSQTDSEANMEKSH 864

  Fly  7943 ------EIDANGRKLRGKADGPVKDYDSYVFDIYSKFVPQPVEISQQSVYDRYDILEEIGTGAFG 8001
                  |.::||.......:|...:.||....:.|.....||:....                  
 Frog   865 FQFYPVENNSNGLHANNGVNGDSNNVDSKYISVTSPCTFSPVKEPPP------------------ 911

  Fly  8002 VVHRCRERSTGNIFAAKFIPVSHSVEKDLIRREIDIMNQLH--------HQKLINLH-------- 8050
                              :|....::..:|::   :.||:.        .|..:.|:        
 Frog   912 ------------------VPAKPKLDTQIIQQ---LQNQIRLEQEGAVWKQGSVQLNTPPSPSFP 955

  Fly  8051 --DAFEDDDEMILILEFLSGGELFERITAEGYVMTEAEVINYMRQICEGIRHMHEQNIIHLDIKP 8113
              .:|::.:...||    :..|....:.:....|..|...||.|.         :|.|...::.|
 Frog   956 PPPSFQELEASQLI----TSPEQMNVLNSHNSPMQPASSFNYARP---------KQFIAAQNMSP 1007

  Fly  8114 EN--IMCQTRSSTNVKLIDFGLATRLDPNEVVK-------------------------------- 8144
            .:  |...:.|||:      .|.:.:.|:...|                                
 Frog  1008 TSGYISPSSGSSTS------SLPSPMSPSTPQKQFGRAPVPPFSQPFPQEGEQFWSPASSSPPPP 1066

  Fly  8145 ---ITTGTAEFA---------------------------------APEIVNREPVGFYTDMWAT- 8172
               :.:.||.::                                 ||. .::.|..|.:.|..| 
 Frog  1067 PPPVLSPTANYSVVDAFPLPPPPPPPLPVSVLSPSYSPSPSPTGRAPN-SSQSPAAFISSMLPTQ 1130

  Fly  8173 ---------GVLSYVLLSGL-------SPFAGDNDVQTLKNVKACDWDFDVESFKYISEEAKDFI 8221
                     |:...|:..|.       :..|.|.::|..|:.                       
 Frog  1131 SSPITFNELGLPKGVMPPGFPKKSSRTARIASDEEIQGTKDA----------------------- 1172

  Fly  8222 RKLLVRNKEKRMTAHECLLHPWLTGDHSAMKQEINRDRYLAYREKLRRKYEDFERFLLPIGRLSE 8286
               ::::.|:::...|.||:              |....|.|.||:.|:                
 Frog  1173 ---VIQDLERKLRFKEELLN--------------NGQPKLTYEEKMARR---------------- 1204

  Fly  8287 YSSLRKLLMEKYKIHDAVFDRRQAAPRFVIRPSSQFCYEGQSVKFYCRCIAIATPTLTWSHNNIE 8351
                             :.....||..|.|:...:   :|.:.:......::.:|          
 Frog  1205 -----------------LLGADSAATVFNIQEPEE---DGNAQEVDSLDASVESP---------- 1239

  Fly  8352 LRQSVKFMKRYVGDDYYFIINRVKLDDRGEYIIRAENHYGSREEVVFLNVQPLPKEQPRYRTEST 8416
                                    ||.:.||.:      .|.|:.:...::        ||.|.:
 Frog  1240 ------------------------LDTQKEYKV------SSFEQRLISEIE--------YRLERS 1266

  Fly  8417 PVRRR--------EPLPYTFWQEESETAPSF-TFLLRPRV---MQARDTCKLLCCLSGKPVPNVR 8469
            ||...        ||:       ::..||.| |.|...::   |.:..|||    ::|.|.|.:.
 Frog  1267 PVEESDEEVEHGDEPV-------DNGEAPQFETKLKHYKIFEGMSSTFTCK----VTGNPKPKIY 1320

  Fly  8470 WYKDGRELSK---YEYAMTHSDGVVTMEIIDCKPSDSGKYSCKATNCHGTDETDCVVIVEGEWVT 8531
            |:|||:::||   :.......||..::........|.|.|:..|.|..|.......::|:.    
 Frog  1321 WFKDGKQISKRSEHYRIQREPDGTCSLHTSASSLDDDGNYTIMAANPQGRISCTGRLMVQA---- 1381

  Fly  8532 PEQAQLAHNFLYSGDRKYIEQPIKPAPLPIVTSRQYTSSSVQNTSEPQGDKVNVSNSNSSGISN- 8595
                              :.|..:.|..|         :|..:...|:      |.|..||..| 
 Frog  1382 ------------------VNQRGRTARTP---------TSQLHVRRPR------SRSRDSGDENE 1413

  Fly  8596 ---KKKYASNSLQAPGSPSRSRSATKELILPPDDSLMCKPEFTKPLHDLTIHDGEQLILTCYVKG 8657
               ::.:..:.|||||                               ||.:.:|:...:.|.|.|
 Frog  1414 PIQERFFRPHFLQAPG-------------------------------DLIVQEGKLCRMDCKVSG 1447

  Fly  8658 DPEPQISWSKNGKSL--SSSDILDLRYKNGIATLTINEVFPEDEGVITCTATNSVGAVETKCKLT 8720
            .|.|.:||..||:.:  .:|..:.:| :||:.:|.|..|...|.|:.||.|:|..|......:|.
 Frog  1448 LPTPDLSWQLNGRPVRPDNSHKMLVR-ENGVHSLVIEPVTTRDAGIYTCVASNRAGQNSFTLELI 1511

  Fly  8721 IQPLDKNINKRKVNAGDNAPKIVSHLESRFVRDGDAVNLACRIIGAQHFDVVWLHNNKEIKPSKD 8785
            :...|.:          ..|..:..|::..|.:|..|.|.||:.|.....:.|...|:.:..|  
 Frog  1512 VAAKDAH----------KPPVFIDKLQNTGVAEGYPVRLECRVSGMPPPQIFWKKENESLTYS-- 1564

  Fly  8786 FQYTNEANIYR-------LQIAEIFPEDGGTYTCEAFNDIGESFSTCTINVTV----------PG 8833
               |...::::       |.|.....||.|.||..|.|:.|  ..:||..:.|          |.
 Frog  1565 ---TERVSMHQDNYGYLCLLIQGATKEDAGWYTVSAKNEAG--IVSCTARLDVHTQWHQQSLAPK 1624

  Fly  8834 DETKQPSFVKFPTSVSVLEGEGTTFECEIDSELLNLVWLKDGKPI 8878
            ....:||..::    :.|..:|      :|   :...:|.:..|:
 Frog  1625 TRKVRPSASRY----AALSDQG------LD---IKAAFLPEANPV 1656

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 Ig 9..101 CDD:472250
Ig strand B 26..30 CDD:409353
Ig strand C 39..43 CDD:409353
Ig strand E 69..73 CDD:409353
Ig strand F 83..88 CDD:409353
Ig strand G 96..99 CDD:409353
I-set 119..210 CDD:400151
Ig strand B 136..140 CDD:409353
Ig strand C 149..153 CDD:409353
Ig strand E 174..182 CDD:409353
Ig strand F 192..197 CDD:409353
Ig strand G 205..208 CDD:409353
Ig 228..320 CDD:472250
Ig strand B 245..249 CDD:409353
Ig strand C 258..262 CDD:409353
Ig strand E 286..292 CDD:409353
Ig strand F 302..307 CDD:409353
Ig strand G 317..320 CDD:409353
Ig 335..425 CDD:472250
Ig strand B 350..354 CDD:409353
Ig strand C 363..367 CDD:409353
Ig strand E 393..397 CDD:409353
Ig strand F 407..412 CDD:409353
Ig strand G 420..423 CDD:409353
Ig 438..532 CDD:472250
Ig strand B 455..459 CDD:409353
Ig strand C 468..472 CDD:409353
Ig strand E 498..502 CDD:409353
Ig strand F 512..517 CDD:409353
Ig strand G 525..528 CDD:409353
Ig 545..636 CDD:472250
Ig strand B 560..564 CDD:409353
Ig strand C 573..577 CDD:409353
Ig strand E 599..606 CDD:409353
Ig strand F 616..621 CDD:409353
Ig strand G 629..632 CDD:409353
Ig 656..726 CDD:472250
Ig strand B 657..661 CDD:409353
Ig strand C 670..674 CDD:409353
Ig strand E 700..704 CDD:409353
Ig strand F 714..719 CDD:409353
Ig strand G 728..731 CDD:409353
Ig 746..835 CDD:472250
Ig strand C 777..781 CDD:409353
Ig strand E 802..806 CDD:409353
Ig strand F 816..821 CDD:409353
Ig 1508..1588 CDD:472250
Ig strand B 1514..1518 CDD:409353
Ig strand C 1527..1531 CDD:409353
Ig strand E 1554..1558 CDD:409353
Ig strand F 1568..1573 CDD:409353
Ig strand G 1581..1584 CDD:409353
Ig 1639..1724 CDD:472250
IG_like 1750..1821 CDD:214653
Ig strand B 1750..1753 CDD:409353
Ig strand C 1761..1765 CDD:409353
Ig strand E 1788..1792 CDD:409353
Ig strand F 1802..1806 CDD:409353
Ig 1826..1909 CDD:472250
Ig strand B 1842..1846 CDD:409353
Ig strand C 1854..1858 CDD:409353
Ig strand E 1879..1883 CDD:409353
Ig 1914..1998 CDD:472250
Ig 2020..2095 CDD:472250
Ig strand B 2021..2025 CDD:409353
Ig strand C 2038..2042 CDD:409353
Ig strand E 2062..2066 CDD:409353
Ig strand F 2076..2081 CDD:409353
Ig strand G 2089..2092 CDD:409353
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
Ig 2314..2395 CDD:472250
Ig strand B 2322..2326 CDD:409353
Ig strand C 2335..2339 CDD:409353
Ig strand E 2361..2365 CDD:409353
Ig strand F 2375..2380 CDD:409353
FN3 <2376..2753 CDD:442628
Ig strand G 2388..2391 CDD:409353
FN3 2501..2590 CDD:238020
FN3 <2673..>2891 CDD:442628
Ig 2902..2995 CDD:472250
Ig strand B 2920..2924 CDD:409353
Ig strand C 2933..2937 CDD:409353
FN3 <2957..>3191 CDD:442628
Ig strand E 2961..2965 CDD:409353
Ig strand F 2975..2980 CDD:409353
Ig strand G 2988..2991 CDD:409353
FN3 2999..3088 CDD:238020
Ig 3212..3292 CDD:472250
Ig strand B 3220..3224 CDD:409353
Ig strand C 3233..3237 CDD:409353
Ig strand E 3258..3262 CDD:409353
Ig strand F 3272..3277 CDD:409353
Ig strand G 3285..3288 CDD:409353
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:400151
Ig strand B 3517..3521 CDD:409353
Ig strand C 3530..3534 CDD:409353
Ig strand E 3556..3560 CDD:409353
Ig strand F 3570..3575 CDD:409353
Ig strand G 3583..3586 CDD:409353
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:400151
Ig strand B 3813..3817 CDD:409353
Ig strand C 3826..3830 CDD:409353
Ig strand E 3851..3855 CDD:409353
Ig strand F 3865..3870 CDD:409353
FN3 <3866..4181 CDD:442628
Ig strand G 3878..3881 CDD:409353
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
FN3 4356..4776 CDD:442628
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
Ig_3 4978..5056 CDD:464046
FN3 <5021..>5264 CDD:442628
FN3 5073..5166 CDD:238020
Ig 5286..5366 CDD:472250
Ig strand B 5294..5298 CDD:409353
Ig strand C 5307..5311 CDD:409353
Ig strand E 5332..5336 CDD:409353
Ig strand F 5346..5351 CDD:409353
Ig strand G 5359..5362 CDD:409353
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:472250
Ig strand B 5588..5592 CDD:409353
Ig strand C 5601..5605 CDD:409353
Ig strand E 5626..5630 CDD:409353
Ig strand F 5640..5645 CDD:409353
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
Ig 5874..5954 CDD:472250
Ig strand B 5882..5886 CDD:409353
Ig strand C 5895..5899 CDD:409353
Ig strand E 5920..5924 CDD:409353
Ig strand F 5934..5939 CDD:409353
Ig strand G 5947..5950 CDD:409353
FN3 <5972..>6384 CDD:442628
Ig_Titin_like 6174..6255 CDD:409406
Ig strand A 6174..6178 CDD:409406
Ig strand B 6183..6189 CDD:409406
Ig strand C 6195..6201 CDD:409406
Ig strand D 6213..6218 CDD:409406
Ig strand E 6219..6225 CDD:409406
Ig strand F 6234..6242 CDD:409406
FN3 <6236..6552 CDD:442628
Ig strand G 6245..6255 CDD:409406
Ig_Titin_like 6570..6650 CDD:409406
Ig strand A 6570..6573 CDD:409406
Ig strand B 6578..6584 CDD:409406
Ig strand C 6590..6596 CDD:409406
Ig strand D 6608..6613 CDD:409406
Ig strand E 6614..6620 CDD:409406
Ig strand F 6629..6637 CDD:409406
FN3 <6630..7006 CDD:442628
Ig strand G 6640..6650 CDD:409406
FN3 <6905..>7189 CDD:442628
FN3 7151..7237 CDD:238020
Ig 7254..7344 CDD:472250
Ig strand B 7271..7275 CDD:409353
Ig strand C 7284..7288 CDD:409353
Ig strand E 7310..7314 CDD:409353
Ig strand F 7324..7329 CDD:409353
Ig strand G 7337..7340 CDD:409353
Ig 7361..7438 CDD:472250
Ig strand B 7365..7369 CDD:409353
Ig strand C 7378..7382 CDD:409353
Ig strand E 7406..7410 CDD:409353
Ig strand F 7420..7425 CDD:409353
FN3 <7421..7762 CDD:442628 41/199 (21%)
Ig strand G 7433..7436 CDD:409353
I-set 7648..7737 CDD:400151 28/125 (22%)
Ig strand B 7665..7669 CDD:409353 0/3 (0%)
Ig strand C 7678..7682 CDD:409353 1/3 (33%)
Ig strand E 7703..7707 CDD:409353 2/3 (67%)
Ig strand F 7717..7722 CDD:409353 2/4 (50%)
Ig strand G 7730..7733 CDD:409353 0/2 (0%)
Ig 7758..7833 CDD:472250 21/82 (26%)
Ig strand B 7761..7765 CDD:409353 2/3 (67%)
Ig strand C 7774..7778 CDD:409353 0/3 (0%)
Ig strand E 7799..7803 CDD:409353 1/3 (33%)
Ig strand F 7813..7818 CDD:409353 0/4 (0%)
Ig strand G 7826..7829 CDD:409353 0/2 (0%)
FN3 7837..7927 CDD:238020 11/89 (12%)
STKc_Twitchin_like 7986..8244 CDD:271016 44/362 (12%)
Ig 8313..8401 CDD:472250 10/87 (11%)
Ig strand B 8329..8333 CDD:409541 0/3 (0%)
Ig strand C 8342..8346 CDD:409541 0/3 (0%)
Ig strand E 8367..8371 CDD:409541 0/3 (0%)
Ig strand F 8381..8386 CDD:409541 2/4 (50%)
Ig strand G 8394..8397 CDD:409541 1/2 (50%)
I-set 8437..8525 CDD:400151 25/94 (27%)
Ig strand B 8454..8458 CDD:409353 2/3 (67%)
Ig strand C 8467..8471 CDD:409353 0/3 (0%)
Ig strand E 8491..8495 CDD:409353 0/3 (0%)
Ig strand F 8505..8510 CDD:409353 1/4 (25%)
Ig strand G 8518..8521 CDD:409353 0/2 (0%)
I-set 8632..8721 CDD:400151 27/90 (30%)
Ig strand B 8649..8653 CDD:409570 0/3 (0%)
Ig strand C 8662..8666 CDD:409570 1/3 (33%)
Ig strand E 8687..8691 CDD:409570 1/3 (33%)
Ig strand F 8701..8706 CDD:409570 2/4 (50%)
Ig strand G 8714..8717 CDD:409570 0/2 (0%)
I-set 8740..8831 CDD:400151 25/97 (26%)
Ig strand B 8757..8761 CDD:409353 2/3 (67%)
Ig strand C 8770..8774 CDD:409353 0/3 (0%)
Ig strand E 8795..8799 CDD:409353 1/10 (10%)
Ig strand F 8809..8814 CDD:409353 2/4 (50%)
Ig strand G 8822..8825 CDD:409353 0/2 (0%)
Ig 8839..8922 CDD:472250 7/40 (18%)
Ig strand B 8856..8860 CDD:409353 0/3 (0%)
Ig strand C 8868..8872 CDD:409353 0/3 (0%)
Ig strand E 8894..8898 CDD:409353
palldXP_017951326.2 Mplasa_alph_rch 256..>508 CDD:275316
Ig 530..624 CDD:472250 26/95 (27%)
Ig strand B 551..555 CDD:409353 0/3 (0%)
Ig strand C 564..568 CDD:409353 1/3 (33%)
Ig strand E 590..594 CDD:409353 2/3 (67%)
Ig strand F 604..609 CDD:409353 2/4 (50%)
Ig strand G 617..620 CDD:409353 0/2 (0%)
I-set 704..801 CDD:400151 22/96 (23%)
Ig strand B 721..725 CDD:409353 2/3 (67%)
Ig strand C 734..738 CDD:409353 0/3 (0%)
Ig strand E 767..771 CDD:409353 1/3 (33%)
Ig strand F 781..786 CDD:409353 0/4 (0%)
Ig strand G 794..797 CDD:409353 0/2 (0%)
Ig 1288..1379 CDD:472250 25/94 (27%)
Ig strand B 1305..1309 CDD:409474 0/3 (0%)
Ig strand C 1318..1322 CDD:409474 0/3 (0%)
Ig strand E 1345..1349 CDD:409474 0/3 (0%)
Ig strand F 1359..1364 CDD:409474 1/4 (25%)
Ig strand G 1372..1375 CDD:409474 0/2 (0%)
Ig 1422..1512 CDD:472250 32/121 (26%)
Ig strand B 1439..1443 CDD:409353 0/3 (0%)
Ig strand C 1452..1456 CDD:409353 1/3 (33%)
Ig strand E 1478..1482 CDD:409353 1/3 (33%)
Ig strand F 1492..1497 CDD:409353 2/4 (50%)
Ig strand G 1505..1508 CDD:409353 0/2 (0%)
IgI_Myotilin_C 1521..1612 CDD:409473 25/97 (26%)
Ig strand A 1521..1524 CDD:409473 1/2 (50%)
Ig strand A' 1527..1532 CDD:409473 1/4 (25%)
Ig strand B 1537..1544 CDD:409473 3/6 (50%)
Ig strand C 1551..1557 CDD:409473 1/5 (20%)
Ig strand C' 1558..1561 CDD:409473 1/2 (50%)
Ig strand D 1568..1574 CDD:409473 0/5 (0%)
Ig strand E 1577..1587 CDD:409473 2/9 (22%)
Ig strand F 1591..1599 CDD:409473 4/7 (57%)
Ig strand G 1601..1612 CDD:409473 3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

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