DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and myom1

DIOPT Version :10

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:XP_031759524.1 Gene:myom1 / 100101675 XenbaseID:XB-GENE-923326 Length:1555 Species:Xenopus tropicalis


Alignment Length:1683 Identity:366/1683 - (21%)
Similarity:576/1683 - (34%) Gaps:495/1683 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly  5562 ICKPRFLAPFFDKSLLNDITVHAGKRLGWTLPIEASPRPLITWLYNGKEIGSNSRGES------- 5619
            |.|||....:..:::....||.     ||       |.|.:||..|...|...:..|.       
 Frog   185 IIKPRSHTIWETQNVKLHCTVS-----GW-------PEPRVTWYKNNVPIDDQAHPEKYKIEGGY 237

  Fly  5620 GLFQNEL---TFEIVS-------SLRSDEGRY-TLILKNEHGSFDASAHATVLDRPSPPKGPLDI 5673
            |:...|:   .||..:       :::.:...| :|::|...|..|.||.        |||.....
 Frog   238 GIHSLEIFKCDFEDTAQYHASAMNVKGENSAYASLVVK
RYKGDLDDSAF--------PPKSTPFS 294

  Fly  5674 TKITRDGCHLTWNVPDDD---------------GGSPILHYIIEKMD-----------LSRSTWS 5712
            ..:|..|....:::...|               |...|:|..|::..           ||.|.|.
 Frog   295 FSVTPYGFASKFDIHFVDSFGVSFGKEGETLSLGSKVIIHPTIKRFQPEIQWYKNGVLLSPSKWR 359

  Fly  5713 DAGMS-THIVHDVTRLVHRKEYLFRVKAVNAIGESDPLEAVNTIIAKNEFDEPDAPGKPI---IT 5773
            :...| .|....:|.|....|.|:.::||  :||.....:....:...|.:...||..|:   ..
 Frog   360 NMHWSGEHSTLTLTHLNKEDEGLYTLRAV--MGEYYEQYSAYVFVRDAEAEVAGAPAAPLDVECL 422

  Fly  5774 DWDRDHIDLQWAVPKSDGGAPISEYIIQKKEKGSPYWTNVRHVPSNKNTTTIPELTEGQEYEFRV 5838
            |.::|::.:.|..|..|||:.|..|.|.:.|.|:.:||.....|.......:..|.||:.|.|||
 Frog   423 DANKDYVIISWKQPAVDGGSSILGYFIDRCEVGTQHWTQCNDTPVKFARFPVTGLIEGRSYIFRV 487

  Fly  5839 IAVNQAGQSEPSEPSDMIMAKPRYLPPKIITPLNEVRIKCGLIFHTDIHFIGEPAPEATWTLNSN 5903
            .|||:.|.|.||..|:.:.|         :.|.:..||||              .|.|.||    
 Frog   488 RAVNKTGISRPSRVSEPVAA---------LDPADRARIKC--------------RPSAPWT---- 525

  Fly  5904 PLLSNDRSTITSIGHHSVVHTVNCQRSDSGIYHLLLRNSSGIDEGSFELVVLDRPGPPEGPMEYE 5968
                           ..::.|                     :|...|.|:   ||||. .:...
 Frog   526 ---------------GQIIVT---------------------EEEPTEGVI---PGPPT-DLTVT 550

  Fly  5969 EITANSVTISWKPPKDNGGSEISSYVIEKRDLTHGGGWVPAVNYVSAKYNHAVVPRLLEGTMYEL 6033
            |.|.|.|.:|||||...|...:..||  ::.:.....|......:..|.....:..|.||..|..
 Frog   551 EATKNYVVLSWKPPGQRGHEGVMYYV--EKCVAGIDNWQRVNTEIPVKSPRFALFDLAEGKSYSF 613

  Fly  6034 RVMAENLQGRSDPLTSDQPVVAKSQYTVPGAPGKPELTDSDKNHITIKWKQPISNGGSPIIGYDI 6098
            ||.:.|..|..:|..:.:..|...:..:|........|.:....:.:.|.:  |.....::||.|
 Frog   614 RVRSCNSAGVGEPSEATEATVVGDKLDIPPPASNIIPTRNTDTSVVVTWTE--SKDARELVGYYI 676

  Fly  6099 ERRDVNTGRWIKINGQPVPTAEYQDDRVTSNHQYQYRISAVNAAG-NGKTSEPSAIFNARPLREK 6162
            |.....:|.|...|..||....:....:.:..:|.:|:.|||||| :..:|:..||         
 Frog   677 EASIAGSGHWEPCNNNPVKGKRFICHGLLTGQKYVFRVRAVNAAGLSDYSSDSEAI--------- 732

  Fly  6163 PRFYFDGLIGKRIKVRAGEPVNLNIPISGAPTPTIEWKRGDLKLEEGKRISYETNSERTLFRIDD 6227
                       .:|...|         .|.|..|                               
 Frog   733 -----------EVKAAIG---------GGLPHAT------------------------------- 746

  Fly  6228 SNRRDSGKYTVTAANEFGKDTADIEVIVVDKPSPPEGPLSYTETAPDHISLHWYSPKDDGGSDIT 6292
                                           ||||. .::..|:..|.:.|.|..||..||.||.
 Frog   747 -------------------------------PSPPY-DITILESVRDSMVLGWKEPKITGGLDIK 779

  Fly  6293 GYIIEFTEFGVDDWKPVPGTCPNTN--------FTVKNLVEGKKYVFRIRAENIYGASEALEGKP 6349
            ||.:.|.|. :|.   |.|.....|        :.:.||.|...|.:.:.|.|:.|.     |.|
 Frog   780 GYYVNFREV-IDG---VAGQWHEANIKAISERAYRILNLKENTVYQYEVMACNLAGV-----GTP 835

  Fly  6350 VLAKSPFD-------PPGAPSQPTISAYTPNSANLEWHPPDDCGGKPITGYIVERRE--RGGE-W 6404
            .....||.       .||.|.|.|:......|..|.|.||...|..|:|||.::.:|  .|.| |
 Frog   836 SQPSKPFKCEEWTIAVPGPPHQLTLREVRSTSMVLLWQPPVYTGRNPVTGYYIDIKEADAGDERW 900

  Fly  6405 IKCNNYPTPNTSYTVSNLRDGARYEFRVLAVNEAGPGHPSKPSDPMTAEHQRYRPDPPEPP---- 6465
            ...|...|.|....:.:|::||||..||.|||:||.|..|..:||:.|:   .:|...|..    
 Frog   901 RGVNEKQTANKYIKIVDLQEGARYVLRVRAVNQAGVGKSSDLTDPVLAQ---TKPGTKEVEVIVD 962

  Fly  6466 ---------KPDRITRNGVTLSWR---PPRTDGKSRIKGYYVEMRPKNG------KDWKTVNDIP 6512
                     :.|::|.:...: |.   .|..|..||     |.:..|.|      || .:..|:.
 Frog   963 DDGIISLNFECDQLTPDSKFI-WSKNYEPIDDDSSR-----VSVETKGGRTKVSFKD-PSEEDLG 1020

  Fly  6513 INSTVYTVPSLKEGEEYSFRVVAENEVGR-----SDPSKPSQPITIEEQPNKPCMELGKVRDIVC 6572
            |.|.|.|.   .:|...|:.:.|| |:.|     .|...|..|:..|....  .:|.|:||    
 Frog  1021 IYSCVVTE---TDGVSSSYTLDAE-ELKRLLQLSHDNKYPVIPLKSELAVE--ILEKGQVR---- 1075

  Fly  6573 RAGDDFSIHVPYLAFPKPNA-----FWYSNDNMLDDNNRVHKHLTDDA--ASVVVKNSKRADSGQ 6630
                 |.:....|:   |||     |   ||..:.|.::.:..:..:.  |.:|::..:..|.|.
 Frog  1076 -----FWMQAEKLS---PNAKVNHVF---NDKEIKDGDKYNMSMDRNTGIAQMVMEKLEDEDEGT 1129

  Fly  6631 YRLQLKNTSGFDTATINV--RVLDRPSPPTRLRADEF---SGDSLTLY--W-------------- 6674
            |..||::....:.:::.:  .|.::.....|.:..|:   .|.....|  |              
 Frog  1130 YTFQLQDGKATNQSSLVLIGDVFEKLKKEARFQRQEWIRKQGPHFVEYLGWEVTPECNVLLKSKV 1194

  Fly  6675 -NPPNDDGGSAIQNYIIEKKEARSSTWSKVSSFCTV---PFVR----IRNLVLNKE--------- 6722
             |..||   :.|..||.|::.............||:   .|.:    :..|:|..:         
 Frog  1195 ANIRND---TNISWYIDEREIMEDEKHEFKDGVCTLLITEFTKKDAGVYELILRDDRGKDKSVLK 1256

  Fly  6723 -----YD------FRVIAENKYGQSDPANTSEPILARHPFDIPNTPGIPHGIDSTEDSITIAWTK 6776
                 :|      .:||||:  .......::|..:..:.|           ::...|.:.::|. 
 Frog  1257 LMDSAFDDLMSAVCKVIAES--ASQLKIQSNEEGIRLYTF-----------VNYFVDDLKVSWC- 1307

  Fly  6777 PKHDGG---------SPITGYIIEKRL---LSDDKWT--------KAVHALCPDLSCKIPNLIEN 6821
              |:.|         :.:||.:|..::   ..:||..        |:.|....|||   ....:.
 Frog  1308 --HNDGKIKYTDRVKTGVTGEMIWLQINEPTPNDKGKYVLEMFDGKSTHTRDVDLS---GQAYDE 1367

  Fly  6822 AEYEF---RVAAVNAAGQSAYSGSSDLIFCRRPPHAPKITSDLSIRDMTVIAGDEFRITVPYHAS 6883
            |..||   :.||:....::..:|.           .|.:        :|:..|....:|......
 Frog  1368 AFAEFQRLKQAAIAEKNRARVTGG-----------LPDV--------VTIQEGKALNLTCNIWGD 1413

  Fly  6884 PRPTASWSLNGLEVIPGER--IKFDSNDYASMYYNKSAKRDETGSYTITLTNNKGSDTASCHVTV 6946
            |.|..:|..|..|:|..:.  :||::..|||......:..| :|.|.|...|..|::|       
 Frog  1414 PVPEVTWLKNERELIGDDHCILKFEAGKYASFTITCVSTTD-SGKYAIRAKNKYGTET------- 1470

  Fly  6947 VDRPLPPQGPLNAYDITPDTCTLAWKTPLDDGGSPITNYVVEKLDNSGSWVKISSFVRNTHYDVM 7011
                                             :..|..|...:...|    ::.:|.:....||
 Frog  1471 ---------------------------------NDFTLIVTHMMGELG----MAMYVADAAGHVM 1498

  Fly  7012 -----GLEPHYKYNFRVRAENQYGLSDPLDIIEPIVAKHQFTVPDEPGQPKVIDWDSG 7064
                 |.:...|..||.:..::..|..|  .:|.|||..:...|||  :|.|.:.|:|
 Frog  1499 ETVTPGKKKEPKSKFRTKEVSKQDLVKP--HVEEIVATEETPGPDE--KPIVEEEDNG 1552

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 Ig 9..101 CDD:472250
Ig strand B 26..30 CDD:409353
Ig strand C 39..43 CDD:409353
Ig strand E 69..73 CDD:409353
Ig strand F 83..88 CDD:409353
Ig strand G 96..99 CDD:409353
I-set 119..210 CDD:400151
Ig strand B 136..140 CDD:409353
Ig strand C 149..153 CDD:409353
Ig strand E 174..182 CDD:409353
Ig strand F 192..197 CDD:409353
Ig strand G 205..208 CDD:409353
Ig 228..320 CDD:472250
Ig strand B 245..249 CDD:409353
Ig strand C 258..262 CDD:409353
Ig strand E 286..292 CDD:409353
Ig strand F 302..307 CDD:409353
Ig strand G 317..320 CDD:409353
Ig 335..425 CDD:472250
Ig strand B 350..354 CDD:409353
Ig strand C 363..367 CDD:409353
Ig strand E 393..397 CDD:409353
Ig strand F 407..412 CDD:409353
Ig strand G 420..423 CDD:409353
Ig 438..532 CDD:472250
Ig strand B 455..459 CDD:409353
Ig strand C 468..472 CDD:409353
Ig strand E 498..502 CDD:409353
Ig strand F 512..517 CDD:409353
Ig strand G 525..528 CDD:409353
Ig 545..636 CDD:472250
Ig strand B 560..564 CDD:409353
Ig strand C 573..577 CDD:409353
Ig strand E 599..606 CDD:409353
Ig strand F 616..621 CDD:409353
Ig strand G 629..632 CDD:409353
Ig 656..726 CDD:472250
Ig strand B 657..661 CDD:409353
Ig strand C 670..674 CDD:409353
Ig strand E 700..704 CDD:409353
Ig strand F 714..719 CDD:409353
Ig strand G 728..731 CDD:409353
Ig 746..835 CDD:472250
Ig strand C 777..781 CDD:409353
Ig strand E 802..806 CDD:409353
Ig strand F 816..821 CDD:409353
Ig 1508..1588 CDD:472250
Ig strand B 1514..1518 CDD:409353
Ig strand C 1527..1531 CDD:409353
Ig strand E 1554..1558 CDD:409353
Ig strand F 1568..1573 CDD:409353
Ig strand G 1581..1584 CDD:409353
Ig 1639..1724 CDD:472250
IG_like 1750..1821 CDD:214653
Ig strand B 1750..1753 CDD:409353
Ig strand C 1761..1765 CDD:409353
Ig strand E 1788..1792 CDD:409353
Ig strand F 1802..1806 CDD:409353
Ig 1826..1909 CDD:472250
Ig strand B 1842..1846 CDD:409353
Ig strand C 1854..1858 CDD:409353
Ig strand E 1879..1883 CDD:409353
Ig 1914..1998 CDD:472250
Ig 2020..2095 CDD:472250
Ig strand B 2021..2025 CDD:409353
Ig strand C 2038..2042 CDD:409353
Ig strand E 2062..2066 CDD:409353
Ig strand F 2076..2081 CDD:409353
Ig strand G 2089..2092 CDD:409353
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
Ig 2314..2395 CDD:472250
Ig strand B 2322..2326 CDD:409353
Ig strand C 2335..2339 CDD:409353
Ig strand E 2361..2365 CDD:409353
Ig strand F 2375..2380 CDD:409353
FN3 <2376..2753 CDD:442628
Ig strand G 2388..2391 CDD:409353
FN3 2501..2590 CDD:238020
FN3 <2673..>2891 CDD:442628
Ig 2902..2995 CDD:472250
Ig strand B 2920..2924 CDD:409353
Ig strand C 2933..2937 CDD:409353
FN3 <2957..>3191 CDD:442628
Ig strand E 2961..2965 CDD:409353
Ig strand F 2975..2980 CDD:409353
Ig strand G 2988..2991 CDD:409353
FN3 2999..3088 CDD:238020
Ig 3212..3292 CDD:472250
Ig strand B 3220..3224 CDD:409353
Ig strand C 3233..3237 CDD:409353
Ig strand E 3258..3262 CDD:409353
Ig strand F 3272..3277 CDD:409353
Ig strand G 3285..3288 CDD:409353
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:400151
Ig strand B 3517..3521 CDD:409353
Ig strand C 3530..3534 CDD:409353
Ig strand E 3556..3560 CDD:409353
Ig strand F 3570..3575 CDD:409353
Ig strand G 3583..3586 CDD:409353
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:400151
Ig strand B 3813..3817 CDD:409353
Ig strand C 3826..3830 CDD:409353
Ig strand E 3851..3855 CDD:409353
Ig strand F 3865..3870 CDD:409353
FN3 <3866..4181 CDD:442628
Ig strand G 3878..3881 CDD:409353
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
FN3 4356..4776 CDD:442628
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
Ig_3 4978..5056 CDD:464046
FN3 <5021..>5264 CDD:442628
FN3 5073..5166 CDD:238020
Ig 5286..5366 CDD:472250
Ig strand B 5294..5298 CDD:409353
Ig strand C 5307..5311 CDD:409353
Ig strand E 5332..5336 CDD:409353
Ig strand F 5346..5351 CDD:409353
Ig strand G 5359..5362 CDD:409353
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:472250 23/109 (21%)
Ig strand B 5588..5592 CDD:409353 2/3 (67%)
Ig strand C 5601..5605 CDD:409353 1/3 (33%)
Ig strand E 5626..5630 CDD:409353 1/6 (17%)
Ig strand F 5640..5645 CDD:409353 2/5 (40%)
FN3 5664..5755 CDD:238020 24/117 (21%)
FN3 5764..5853 CDD:238020 32/91 (35%)
Ig 5874..5954 CDD:472250 11/79 (14%)
Ig strand B 5882..5886 CDD:409353 0/3 (0%)
Ig strand C 5895..5899 CDD:409353 1/3 (33%)
Ig strand E 5920..5924 CDD:409353 0/3 (0%)
Ig strand F 5934..5939 CDD:409353 0/4 (0%)
Ig strand G 5947..5950 CDD:409353 1/2 (50%)
FN3 <5972..>6384 CDD:442628 94/427 (22%)
Ig_Titin_like 6174..6255 CDD:409406 5/80 (6%)
Ig strand A 6174..6178 CDD:409406 1/3 (33%)
Ig strand B 6183..6189 CDD:409406 0/5 (0%)
Ig strand C 6195..6201 CDD:409406 1/5 (20%)
Ig strand D 6213..6218 CDD:409406 0/4 (0%)
Ig strand E 6219..6225 CDD:409406 0/5 (0%)
Ig strand F 6234..6242 CDD:409406 0/7 (0%)
FN3 <6236..6552 CDD:442628 100/360 (28%)
Ig strand G 6245..6255 CDD:409406 0/9 (0%)
Ig_Titin_like 6570..6650 CDD:409406 16/88 (18%)
Ig strand A 6570..6573 CDD:409406 0/2 (0%)
Ig strand B 6578..6584 CDD:409406 1/5 (20%)
Ig strand C 6590..6596 CDD:409406 4/10 (40%)
Ig strand D 6608..6613 CDD:409406 0/4 (0%)
Ig strand E 6614..6620 CDD:409406 1/7 (14%)
Ig strand F 6629..6637 CDD:409406 4/7 (57%)
FN3 <6630..7006 CDD:442628 74/449 (16%)
Ig strand G 6640..6650 CDD:409406 0/11 (0%)
FN3 <6905..>7189 CDD:442628 34/165 (21%)
FN3 7151..7237 CDD:238020
Ig 7254..7344 CDD:472250
Ig strand B 7271..7275 CDD:409353
Ig strand C 7284..7288 CDD:409353
Ig strand E 7310..7314 CDD:409353
Ig strand F 7324..7329 CDD:409353
Ig strand G 7337..7340 CDD:409353
Ig 7361..7438 CDD:472250
Ig strand B 7365..7369 CDD:409353
Ig strand C 7378..7382 CDD:409353
Ig strand E 7406..7410 CDD:409353
Ig strand F 7420..7425 CDD:409353
FN3 <7421..7762 CDD:442628
Ig strand G 7433..7436 CDD:409353
I-set 7648..7737 CDD:400151
Ig strand B 7665..7669 CDD:409353
Ig strand C 7678..7682 CDD:409353
Ig strand E 7703..7707 CDD:409353
Ig strand F 7717..7722 CDD:409353
Ig strand G 7730..7733 CDD:409353
Ig 7758..7833 CDD:472250
Ig strand B 7761..7765 CDD:409353
Ig strand C 7774..7778 CDD:409353
Ig strand E 7799..7803 CDD:409353
Ig strand F 7813..7818 CDD:409353
Ig strand G 7826..7829 CDD:409353
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
Ig 8313..8401 CDD:472250
Ig strand B 8329..8333 CDD:409541
Ig strand C 8342..8346 CDD:409541
Ig strand E 8367..8371 CDD:409541
Ig strand F 8381..8386 CDD:409541
Ig strand G 8394..8397 CDD:409541
I-set 8437..8525 CDD:400151
Ig strand B 8454..8458 CDD:409353
Ig strand C 8467..8471 CDD:409353
Ig strand E 8491..8495 CDD:409353
Ig strand F 8505..8510 CDD:409353
Ig strand G 8518..8521 CDD:409353
I-set 8632..8721 CDD:400151
Ig strand B 8649..8653 CDD:409570
Ig strand C 8662..8666 CDD:409570
Ig strand E 8687..8691 CDD:409570
Ig strand F 8701..8706 CDD:409570
Ig strand G 8714..8717 CDD:409570
I-set 8740..8831 CDD:400151
Ig strand B 8757..8761 CDD:409353
Ig strand C 8770..8774 CDD:409353
Ig strand E 8795..8799 CDD:409353
Ig strand F 8809..8814 CDD:409353
Ig strand G 8822..8825 CDD:409353
Ig 8839..8922 CDD:472250
Ig strand B 8856..8860 CDD:409353
Ig strand C 8868..8872 CDD:409353
Ig strand E 8894..8898 CDD:409353
myom1XP_031759524.1 IgI_titin_I1-like 182..275 CDD:409543 21/101 (21%)
Ig strand A 182..184 CDD:409543
Ig strand A' 186..192 CDD:409543 3/5 (60%)
Ig strand B 199..206 CDD:409543 1/6 (17%)
Ig strand C 212..217 CDD:409543 2/4 (50%)
Ig strand C' 219..222 CDD:409543 0/2 (0%)
Ig strand D 230..234 CDD:409543 0/3 (0%)
Ig strand E 239..246 CDD:409543 1/6 (17%)
Ig strand F 253..261 CDD:409543 0/7 (0%)
Ig strand G 264..275 CDD:409543 2/10 (20%)
Ig 320..388 CDD:472250 14/67 (21%)
Ig strand C 343..347 CDD:409353 0/3 (0%)
Ig strand E 368..372 CDD:409353 0/3 (0%)
Ig strand F 382..387 CDD:409353 1/4 (25%)
FN3 413..503 CDD:238020 31/89 (35%)
FN3 <474..>784 CDD:442628 102/472 (22%)
FN3 747..839 CDD:238020 31/101 (31%)
FN3 852..941 CDD:238020 35/88 (40%)
Ig 955..1027 CDD:472250 17/78 (22%)
Ig strand B 969..973 CDD:409405 0/3 (0%)
Ig strand C 981..985 CDD:409405 0/4 (0%)
Ig strand E 1007..1011 CDD:409405 0/3 (0%)
Ig strand F 1021..1026 CDD:409405 2/4 (50%)
Ig <1193..1257 CDD:472250 12/66 (18%)
Ig strand C 1202..1206 CDD:409521 1/3 (33%)
Ig strand E 1225..1229 CDD:409521 2/3 (67%)
Ig strand F 1239..1244 CDD:409521 1/4 (25%)
Ig strand G 1252..1255 CDD:409521 0/2 (0%)
Ig 1386..1477 CDD:472250 24/150 (16%)
Ig strand B 1404..1408 CDD:409353 0/3 (0%)
Ig strand C 1417..1421 CDD:409353 0/3 (0%)
Ig strand E 1443..1447 CDD:409353 2/3 (67%)
Ig strand F 1457..1462 CDD:409353 2/4 (50%)
Ig strand G 1470..1473 CDD:409353 1/42 (2%)
Blue background indicates that the domain is not in the aligned region.

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