DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bt and lama2

DIOPT Version :9

Sequence 1:	NP_001162825.1	Gene:	bt / 43814	FlyBaseID:	FBgn0005666	Length:	8933	Species:	Drosophila melanogaster
Sequence 2:	NP_001265728.1	Gene:	lama2 / 100049705	ZFINID:	ZDB-GENE-060119-1	Length:	3078	Species:	Danio rerio

Alignment Length:	777	Identity:	140/777 - (18%)
Similarity:	276/777 - (35%)	Gaps:	248/777 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   580 GEVIKESNKI---KTFIEQRGDQYYIKLELLDPQLEDSGLYKCNIKNTL----------GELNAN 631
            |.::.|.:::   .|.:...|:|.....|......|:..||   ::|||          .:|||.
Zfish  1572 GSLVTEMDELLNRATKVSADGEQTAADAERSRKAAEELELY---VRNTLLAAEALRDKARDLNAT 1633

  Fly   632 L-----TLNIEIVPVIKDKPKIIKIIKKRTVVIECTVASKFEPKCTWYKETSTVKESKRHVYQVE 691
            |     ||...:..:..:..:::..::||.:.                        .|:|
Zfish  1634 LGLRDGTLEKSVNEMNDEIQEMLAELRKRQLT------------------------GKKH----- 1669

  Fly   692 QTKEGEFAVKLEINDVEESDKGAYKLVASNEKGEA---VSQIVNLVDIPEEERKPCKPEISRKLA 753
                                      :|..|.|.|   :|::..|...|::.....|.|:.:|::
Zfish  1670 --------------------------MADEELGAAEALLSRVKRLFGDPQQATADLKQEVGQKMS 1708

  Fly   754 DQKVAESKTFELL-VSLSQTDRKCKVEWYKGSTVIRETKDITTTFDGTTARLTFSSARTEHTSNY 817
            |.|:...:..||| .:|:.|               |:.:|:|
Zfish  1709 DHKLKLQEAQELLEEALTHT---------------RQAEDLT----------------------- 1735

  Fly   818 KVIVTNEVGKDESSCKITVEKVAKKKEEKPKEKEKTKNEKEVEQKEMEEDKNESGQSVAQTEGRI 882
               :.|:         :.::.:..|::...|:||:|:......:|.::|   .:..|.|.|.|:.
Zfish  1736 ---LNNQ---------LKLQHLQGKRDAAVKQKEQTEGVLLEGEKSLDE---ANALSDAITRGKE 1785

  Fly   883 NIEQISE--GDPKEELTVKEEILDKRDTQEVKESSVELQDSAG---------------------- 923
            .:|:::.  |..:::|..||..|.:...:.|.|..:..:|.|.
Zfish  1786 ELEEMAGELGPLRDQLRDKESDLSRGLDESVPELLLRAEDHAAQLNHSAAILDSILAEAKNLSFN 1850

  Fly   924 ------------HEVPEPKKATSDSKLDQSNQKNL---DKKHKTDQSESKTNKNVSL---AEPIK 970
                        :.:.|..:...|:|...:....|   .|....||::....|:..|   |:.::
Zfish  1851 ATAAFSAYTNIKNYIEEADRVAKDAKKTSAEALQLASGPKGSLKDQAKGSLQKSHDLLNEAKDLQ 1915

  Fly   971 SNKQESEEQQATEQIGLKKVDRKASIVSVKEEISSDVRRKSTIKAKEEITVDDKKASSRRSSLAV 1035
            .:..|:.|.....|:.||..:::..  .:::.::..|.:.::|.       ||.....:.:.|..
Zfish  1916 KDVTENGENLGALQLRLKGANKQNK--DLQKRLNDTVEKLNSIP-------DDMALKIQATKLKA 1971

  Fly  1036 EESNTESRRSSIIDKKPLEQVDNKPIDANKNPQPLKEEIPRLKPAEKRRTSKVIEEPKPDEGLPK 1100
            .|:|     .:.:|      |.|:..|.|.|...||:...:|:. :.|:|:.:|::|:      |
Zfish  1972 AEAN-----DTALD------VLNRLKDMNLNLMGLKKNYDKLED-DVRKTNNLIKDPE------K 2018

  Fly  1101 LRKASIAQVKE---EAKPAAPKLK----AKAKAKPKYEELPEIPDYERPQLEKYEKSDFTPSDFA 1158
            ...|:.|:||:   ||.....|||    .:...|....::.|:.:..|.|....:.|..:..|..
Zfish  2019 NIHAAGAKVKDLENEADRLMEKLKPIQELQDNLKKNISQIKELINQARKQANSIKVSVLSGGDCI 2083

  Fly  1159 RDLEIPNKMEKPIIDSGKKEPAVLAQKN----------GIPKKTDIIEQYADEPK-------GLK 1206
            |..       :|.|..|:....:|..|.          |..|..|.:.....:.|       |..
Zfish  2084 RTY-------RPEIKKGRYNTIILHLKTLAADNLLFYLGSAKYVDFLAIEMRKGKVNFLWDVGSG 2141

  Fly  1207 VGKGKLPD----EGD---------GRDGAVLKPVIIEPEKEILDLGNKKNNQHADKPTVLDI 1255
            ||:.:.||    :|:         |.:|::....:..|:..||.  :.::.:..:..||||:
Zfish  2142 VGRVEYPDLIINDGNWHRIEASRIGLNGSISVRALEGPKTGILP--SLRSAKAPETYTVLDV 2201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bt	NP_001162825.1	I-set	9..101	CDD:254352
		Ig	26..100	CDD:143165
		I-set	119..210	CDD:254352
		Ig	136..209	CDD:143165
		I-set	228..320	CDD:254352
		IGc2	242..312	CDD:197706
		I-set	335..425	CDD:254352
		Ig	350..423	CDD:143165
		Ig	436..530	CDD:299845
		I-set	438..532	CDD:254352
		I-set	545..636	CDD:254352	18/73 (25%)
		Ig	560..633	CDD:143165	16/70 (23%)
		Ig	657..731	CDD:143165	7/76 (9%)
		I-set	746..835	CDD:254352	13/89 (15%)
		Ig	1496..1586	CDD:299845
		IG_like	1503..1588	CDD:214653
		I-set	1639..1724	CDD:254352
		IG	1750..1821	CDD:214652
		IGc2	1750..1806	CDD:197706
		I-set	1826..1909	CDD:254352
		Ig	1831..1897	CDD:299845
		I-set	1914..1998	CDD:254352
		Ig	2020..2095	CDD:299845
		FN3	2100..2194	CDD:238020
		FN3	2203..2292	CDD:238020
		I-set	2311..2395	CDD:254352
		Ig	2321..2395	CDD:299845
		FN3	2399..2493	CDD:238020
		FN3	2501..2590	CDD:238020
		I-set	2602..2693	CDD:254352
		Ig	2619..2693	CDD:299845
		FN3	2697..2793	CDD:238020
		FN3	2801..2893	CDD:238020
		I-set	2902..2995	CDD:254352
		Ig	2919..2993	CDD:299845
		FN3	2999..3088	CDD:238020
		FN3	3102..3191	CDD:238020
		I-set	3208..3292	CDD:254352
		Ig	3219..3292	CDD:299845
		FN3	3296..3390	CDD:238020
		FN3	3400..3489	CDD:238020
		I-set	3494..3590	CDD:254352
		Ig	3516..3590	CDD:299845
		FN3	3594..3682	CDD:238020
		FN3	3694..3781	CDD:238020
		I-set	3795..3885	CDD:254352
		Ig	3813..3885	CDD:299845
		FN3	3889..3980	CDD:238020
		FN3	3990..4082	CDD:238020
		I-set	4090..4181	CDD:254352
		Ig	4108..4181	CDD:299845
		FN3	4185..4271	CDD:238020
		FN3	4285..4383	CDD:238020
		Ig	4404..4480	CDD:299845
		FN3	4484..4571	CDD:238020
		FN3	4584..4677	CDD:238020
		I-set	4685..4775	CDD:254352
		Ig	4703..4775	CDD:299845
		FN3	4779..4863	CDD:238020
		FN3	4879..4970	CDD:238020
		IG	4989..5069	CDD:214652
		Ig	4996..5069	CDD:299845
		FN3	5073..5166	CDD:238020
		FN3	5175..5265	CDD:238020
I-set	5276..5366	CDD:254352
Ig	5293..5366	CDD:299845
FN3	5370..5462	CDD:238020
FN3	5470..5561	CDD:238020
Ig	5559..5654	CDD:299845
I-set	5570..5660	CDD:254352
FN3	5664..5755	CDD:238020
FN3	5764..5853	CDD:238020
I-set	5865..5954	CDD:254352
Ig	5882..5954	CDD:299845
FN3	5958..6049	CDD:238020
FN3	6062..6153	CDD:238020
I-set	6173..6255	CDD:254352
Ig_Titin_like	6182..6255	CDD:143225
FN3	6259..6350	CDD:238020
FN3	6359..6451	CDD:238020
FN3	6470..6552	CDD:238020
I-set	6564..6650	CDD:254352
Ig_Titin_like	6577..6650	CDD:143225
FN3	6654..6745	CDD:238020
FN3	6754..6840	CDD:238020
I-set	6855..6946	CDD:254352
Ig	6874..6946	CDD:299845
FN3	6950..7042	CDD:238020
FN3	7050..7139	CDD:238020
FN3	7151..7237	CDD:238020
I-set	7254..7334	CDD:254352
Ig	7272..7339	CDD:143165
IG_like	7354..7440	CDD:214653
Ig	7366..7440	CDD:299845
FN3	7444..7531	CDD:238020
FN3	7545..7637	CDD:238020
I-set	7648..7737	CDD:254352
Ig	7665..7734	CDD:143165
Ig	7760..7833	CDD:299845
FN3	7837..7927	CDD:238020
STKc_Twitchin_like	7986..8244	CDD:271016
S_TKc	7989..8244	CDD:214567
Ig	8311..8394	CDD:299845
I-set	8312..8401	CDD:254352
I-set	8437..8525	CDD:254352
Ig	8455..8519	CDD:143165
I-set	8632..8721	CDD:254352
IGc2	8646..8711	CDD:197706
I-set	8740..8831	CDD:254352
Ig	8757..8826	CDD:143165
I-set	8839..8922	CDD:254352
Ig	8845..>8909	CDD:299845
lama2	NP_001265728.1	LamNT	21..270	CDD:214532
		EGF_Lam	272..319	CDD:238012
		Laminin_EGF	399..456	CDD:278482
		Laminin_EGF	454..500	CDD:278482
		Laminin_B	567..695	CDD:278481
		EGF_Lam	742..790	CDD:238012
		Laminin_EGF	792..847	CDD:278482
		EGF_Lam	849..901	CDD:238012
		EGF_Lam	903..948	CDD:214543
		EGF_Lam	951..995	CDD:214543
		EGF_Lam	997..1042	CDD:238012
		Laminin_EGF	1044..1092	CDD:278482
		Laminin_EGF	1090..1147	CDD:278482
		LamB	1212..1340	CDD:214597
		Laminin_EGF	1397..1443	CDD:278482
		EGF_Lam	1446..1495	CDD:214543
		Laminin_I	1526..1780	CDD:283627	51/318 (16%)
		zf-C4H2	1698..>1808	CDD:287156	30/162 (19%)
		Tropomyosin_1	1892..2053	CDD:289488	40/187 (21%)
		Laminin_II	1967..2100	CDD:283628	36/157 (23%)
		Laminin_G_1	2103..2242	CDD:278483	20/101 (20%)
		LamG	2268..2425	CDD:238058
		LamG	2452..2627	CDD:238058
		Laminin_G_1	2750..2878	CDD:278483
		LamG	2898..3050	CDD:238058
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910