DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment bt and ncam1

DIOPT Version :9

Sequence 1:NP_001162825.1 Gene:bt / 43814 FlyBaseID:FBgn0005666 Length:8933 Species:Drosophila melanogaster
Sequence 2:XP_017951446.2 Gene:ncam1 / 100038291 XenbaseID:XB-GENE-923171 Length:1119 Species:Xenopus tropicalis


Alignment Length:1188 Identity:259/1188 - (21%)
Similarity:405/1188 - (34%) Gaps:330/1188 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   133 GKRLLFECRVNADPIPAIIWFHNGAAVKESERHKITVDKDVHSYFATLEILNVTVEDAGKYKVNA 197
            |:...|.|:|:.: ...|.|: :.|..|...:.:|:|.|: ..|.:||.|.||:.:|||.||..|
 Frog    57 GESKFFLCQVSGE-ASDISWY-SPAGEKLLNQQQISVVKN-DGYTSTLTIYNVSSQDAGIYKCVA 118

  Fly   198 KNEL-GESNATISLNFDSDEAPVPESAEGIKPTFTERPVIRQSEDGGNVTFECRCVGDPTPTVTW 261
            .:|. |||..|::|....            |.||...|..::..:|.:....|.........:||
 Frog   119 SSETEGESEGTVNLKIYQ------------KLTFKNAPTPQEFIEGEDAVIICDVSSSIPSIITW 171

  Fly   262 SH-GETELNE--------SNRYKMSLTMDQKLYHIACLEISSVVSSDQGEYRAQAKNKHGSGVAT 317
            .| |:..:.:        ||.|               |:|..|..:|:|.||.:     |..:|.
 Frog   172 RHRGKDVILKKDVRFVVLSNNY---------------LQIRGVKKTDEGTYRCE-----GRILAR 216

  Fly   318 INLNFESGSKKI-------PDGKSPRFPKKPTIRQEEDLLIMECVLEAHPVPDIVWY-------- 367
            ..:|:    |.|       |..::.:.....|...:|. :::.|..:..|.|:|.|.        
 Frog   217 GEINY----KDIHVIVNVPPTVQARQIRVNATANMDES-VVLSCDADGFPDPEISWLKKGEPIED 276

  Fly   368 CSEKEICNNQRTKMTRKAITKDSYILTLEIQNPTKEDGGNYRCNAINMYGESNANIALNFQGASD 432
            ..||...|..:::||              |....|:|...|.|.|.|..||:.|.|.|....   
 Frog   277 GEEKISFNEDKSEMT--------------IYRVGKDDEAEYSCIANNKAGEAEAIILLKVYA--- 324

  Fly   433 ANGFAPSFIEKPRIIPNESGTL-----ITMKCKCKAKPEPTVTWYRGQDLVEKSKKIKINTTVIA 492
                      ||:|...|:.|.     ||:.|:....|.|:::|......:...:|......|:.
 Frog   325 ----------KPKITYVENKTAVELDEITLTCEASGDPIPSISWRTATRNISSEEKTLDGHIVVK 379

  Fly   493 EDTYELTLEIKDPGATDGGTYRCNVKNEYGESNANLNLNIEAEPEPEGEGPTFIEKPRIVSENNG 557
            |......|.:||...||.|.|.|...|..||....:...::..|:.:|        |.:|....|
 Frog   380 EHIRMSALTLKDIQYTDAGEYICIASNAIGEDMRAMYFEVQYAPKIKG--------PVVVYTWEG 436

  Fly   558 KLVIMECKVKADPKPDVIWFRNGEVIKESN--KIKTFIEQRGDQYYIKLELLDPQLEDSGLYKCN 620
            ..|.:.|:|.|.|...|.|||:|:::..||  .||.:......    .||:......|.|.|.|.
 Frog   437 NPVNITCEVLAYPSAVVSWFRDGQLLPSSNFSNIKIYSGPSSS----SLEVNPDSENDFGNYNCT 497

  Fly   621 IKNTLGELNANLTLNIEIVPVIKDKPKIIKIIKKRTVVIECTVASKF-EPKCTW------YK-ET 677
            ..|::|..::      |.:.|..|.|....|:  |......||...| ||..|.      || |.
 Frog   498 AVNSIGHESS------EFILVQADTPSSPAIL--RVEPYSSTVMVIFDEPDATGGVPILKYKAEW 554

  Fly   678 STVKESKRHVYQVEQTKEGEFAVKLEINDVEESDKGAYKLVASNEKG--------EAVSQIVNLV 734
            ..:.:.|.|. :....||......:.:..::.......||.|.|.||        |..:|.||  
 Frog   555 KVIGQEKWHA-KYYDAKEVSAESIITVTGLKPETSYLVKLSAVNGKGLGDSTPSQEFTTQPVN-- 616

  Fly   735 DIPEEERKPCKPE-----------ISRKLADQKVAESKTFELLV---SLSQTDRKCK-------- 777
             |.:.:.:|..|:           :..::..|....|.....||   :|:..|.|.:        
 Frog   617 -IAKPQGEPSAPKLVWHLNEDGNNVKVEIIKQDDGGSPIRHYLVNYRALNAADWKPEMRVPSSSH 680

  Fly   778 ------VEWYKGSTVI-------RETKDITTTFDGTTARLTFSSARTEHTSN------------- 816
                  :||.....||       .::|....:| .|||:.|.::|.|..::.             
 Frog   681 HVMLKALEWNVEYEVIVVAENQQGKSKPARLSF-RTTAKPTATTATTSASAGLGTGAIVGILIVI 744

  Fly   817 --------------------YKVIVTNEVGKDESSCKITVEKVAKKKEEKPKEKEKTKNEKEVEQ 861
                                ...|..|..||.....|      .|..||......|.::::.:.:
 Frog   745 FVLLLVVVDVTCFFLNKCGLLMCIAVNFCGKAGPGAK------GKDIEEGKAAFSKDESKEPIVE 803

  Fly   862 KEMEEDKNESGQSVAQTEGRINIEQISEGDPKEELTVKEEILDK-----RDTQEVKESSVELQDS 921
            ...||::..:.....|.|............|.:.....|::|..     .::..:.|:....|:|
 Frog   804 VRTEEERTPNHDGSNQIEPNETTPLTEPEHPADTTATVEDMLPSVTTVTTNSDTITETFATAQNS 868

  Fly   922 AGHE--------VPEPKKATSDSKLDQSNQKNLDKKHKT-----------------DQSESKTNK 961
            ...|        .|.|   |:||...||.|....|...:                 |.|::.||.
 Frog   869 PTSESTTLTSSTAPPP---TTDSNTVQSIQATPSKAEASTASSPPPTSSPKVAPLVDLSDTPTNN 930

  Fly   962 ----------------NVSLAEPIK--------------SNKQESEEQQA-TEQIGLKKVDRKAS 995
                            ..|.|||.|              |.....|.:|. .||.|.|..:::|:
 Frog   931 PSKAGANQAGALNPSAATSAAEPPKAIIKPVATVPANATSPPPTPEPKQVKQEQSGSKSPEKEAA 995

  Fly   996 IVSVKEEISSDVRRKSTIKAKEEITVDDKKASSRRSSLAVEESNTESRRSSIIDKKPLEQVDNKP 1060
                         :.||:|:..|.|.|:.                    :|:.:.|||:..|.: 
 Frog   996 -------------QPSTVKSPTEATKDES--------------------ASLSNTKPLQGEDFQ- 1026

  Fly  1061 IDANKNPQPLKEEIPRLK----------PA--EKRRTSKVIEEPKPDEGLPKLRKASIAQVKEEA 1113
            ||......|   ||...|          ||  ...:.|:::.........|...|....||:|.:
 Frog  1027 IDGGTFKTP---EIDLAKDVFAALGTATPAAVASGKASELVSSTADTSVPPDSAKTEKTQVEENS 1088

  Fly  1114 KPAAPKLK---AKAKAKP 1128
            ||....:|   |:.|..|
 Frog  1089 KPEETDVKSTPAEVKTVP 1106

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
btNP_001162825.1 I-set 9..101 CDD:254352
Ig 26..100 CDD:143165
I-set 119..210 CDD:254352 28/77 (36%)
Ig 136..209 CDD:143165 27/73 (37%)
I-set 228..320 CDD:254352 21/100 (21%)
IGc2 242..312 CDD:197706 16/78 (21%)
I-set 335..425 CDD:254352 23/97 (24%)
Ig 350..423 CDD:143165 20/80 (25%)
Ig 436..530 CDD:299845 25/98 (26%)
I-set 438..532 CDD:254352 25/98 (26%)
I-set 545..636 CDD:254352 25/92 (27%)
Ig 560..633 CDD:143165 22/74 (30%)
Ig 657..731 CDD:143165 21/89 (24%)
I-set 746..835 CDD:254352 25/156 (16%)
Ig 1496..1586 CDD:299845
IG_like 1503..1588 CDD:214653
I-set 1639..1724 CDD:254352
IG 1750..1821 CDD:214652
IGc2 1750..1806 CDD:197706
I-set 1826..1909 CDD:254352
Ig 1831..1897 CDD:299845
I-set 1914..1998 CDD:254352
Ig 2020..2095 CDD:299845
FN3 2100..2194 CDD:238020
FN3 2203..2292 CDD:238020
I-set 2311..2395 CDD:254352
Ig 2321..2395 CDD:299845
FN3 2399..2493 CDD:238020
FN3 2501..2590 CDD:238020
I-set 2602..2693 CDD:254352
Ig 2619..2693 CDD:299845
FN3 2697..2793 CDD:238020
FN3 2801..2893 CDD:238020
I-set 2902..2995 CDD:254352
Ig 2919..2993 CDD:299845
FN3 2999..3088 CDD:238020
FN3 3102..3191 CDD:238020
I-set 3208..3292 CDD:254352
Ig 3219..3292 CDD:299845
FN3 3296..3390 CDD:238020
FN3 3400..3489 CDD:238020
I-set 3494..3590 CDD:254352
Ig 3516..3590 CDD:299845
FN3 3594..3682 CDD:238020
FN3 3694..3781 CDD:238020
I-set 3795..3885 CDD:254352
Ig 3813..3885 CDD:299845
FN3 3889..3980 CDD:238020
FN3 3990..4082 CDD:238020
I-set 4090..4181 CDD:254352
Ig 4108..4181 CDD:299845
FN3 4185..4271 CDD:238020
FN3 4285..4383 CDD:238020
Ig 4404..4480 CDD:299845
FN3 4484..4571 CDD:238020
FN3 4584..4677 CDD:238020
I-set 4685..4775 CDD:254352
Ig 4703..4775 CDD:299845
FN3 4779..4863 CDD:238020
FN3 4879..4970 CDD:238020
IG 4989..5069 CDD:214652
Ig 4996..5069 CDD:299845
FN3 5073..5166 CDD:238020
FN3 5175..5265 CDD:238020
I-set 5276..5366 CDD:254352
Ig 5293..5366 CDD:299845
FN3 5370..5462 CDD:238020
FN3 5470..5561 CDD:238020
Ig 5559..5654 CDD:299845
I-set 5570..5660 CDD:254352
FN3 5664..5755 CDD:238020
FN3 5764..5853 CDD:238020
I-set 5865..5954 CDD:254352
Ig 5882..5954 CDD:299845
FN3 5958..6049 CDD:238020
FN3 6062..6153 CDD:238020
I-set 6173..6255 CDD:254352
Ig_Titin_like 6182..6255 CDD:143225
FN3 6259..6350 CDD:238020
FN3 6359..6451 CDD:238020
FN3 6470..6552 CDD:238020
I-set 6564..6650 CDD:254352
Ig_Titin_like 6577..6650 CDD:143225
FN3 6654..6745 CDD:238020
FN3 6754..6840 CDD:238020
I-set 6855..6946 CDD:254352
Ig 6874..6946 CDD:299845
FN3 6950..7042 CDD:238020
FN3 7050..7139 CDD:238020
FN3 7151..7237 CDD:238020
I-set 7254..7334 CDD:254352
Ig 7272..7339 CDD:143165
IG_like 7354..7440 CDD:214653
Ig 7366..7440 CDD:299845
FN3 7444..7531 CDD:238020
FN3 7545..7637 CDD:238020
I-set 7648..7737 CDD:254352
Ig 7665..7734 CDD:143165
Ig 7760..7833 CDD:299845
FN3 7837..7927 CDD:238020
STKc_Twitchin_like 7986..8244 CDD:271016
S_TKc 7989..8244 CDD:214567
Ig 8311..8394 CDD:299845
I-set 8312..8401 CDD:254352
I-set 8437..8525 CDD:254352
Ig 8455..8519 CDD:143165
I-set 8632..8721 CDD:254352
IGc2 8646..8711 CDD:197706
I-set 8740..8831 CDD:254352
Ig 8757..8826 CDD:143165
I-set 8839..8922 CDD:254352
Ig 8845..>8909 CDD:299845
ncam1XP_017951446.2 Ig 43..136 CDD:416386 29/81 (36%)
Ig strand A 43..48 CDD:409353
Ig strand A' 51..55 CDD:409353
Ig strand B 57..67 CDD:409353 3/9 (33%)
Ig strand C 71..77 CDD:409353 2/6 (33%)
Ig strand C' 80..82 CDD:409353 0/1 (0%)
Ig strand D 89..95 CDD:409353 3/6 (50%)
Ig strand E 97..105 CDD:409353 4/7 (57%)
Ig strand F 112..120 CDD:409353 4/7 (57%)
Ig strand G 124..135 CDD:409353 5/10 (50%)
IG 144..210 CDD:214652 17/80 (21%)
IgI_3_NCAM-1 231..325 CDD:143207 25/121 (21%)
Ig strand B 251..255 CDD:143207 0/3 (0%)
Ig strand C 264..268 CDD:143207 1/3 (33%)
Ig strand E 288..292 CDD:143207 2/17 (12%)
Ig strand F 302..307 CDD:143207 2/4 (50%)
Ig strand G 315..318 CDD:143207 1/2 (50%)
Ig 324..419 CDD:416386 25/107 (23%)
Ig strand A 324..329 CDD:409353 2/17 (12%)
Ig strand A' 333..337 CDD:409353 1/3 (33%)
Ig strand B 341..349 CDD:409353 3/7 (43%)
Ig strand C 355..361 CDD:409353 1/5 (20%)
Ig strand C' 364..367 CDD:409353 0/2 (0%)
Ig strand D 375..381 CDD:409353 1/5 (20%)
Ig strand E 384..390 CDD:409353 1/5 (20%)
Ig strand F 398..406 CDD:409353 3/7 (43%)
Ig strand G 409..419 CDD:409353 2/9 (22%)
Ig_3 423..500 CDD:404760 25/88 (28%)
Ig strand B 439..443 CDD:409353 1/3 (33%)
Ig strand C 452..456 CDD:409353 1/3 (33%)
Ig strand E 479..483 CDD:409353 1/7 (14%)
Ig strand F 493..498 CDD:409353 2/4 (50%)
FN3 517..612 CDD:238020 23/97 (24%)
FN3 624..709 CDD:238020 14/84 (17%)
Herpes_BLLF1 <776..>1116 CDD:282904 73/377 (19%)
PRK07994 <918..1075 CDD:236138 37/193 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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