DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and LBX2

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001269359.1	Gene:	LBX2 / 85474	HGNCID:	15525	Length:	198	Species:	Homo sapiens

Alignment Length:	254	Identity:	67/254 - (26%)
Similarity:	90/254 - (35%)	Gaps:	81/254 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   371 PTSLSEIPISSAPNIASVTAYASGPSLAHS----LSPPNDIESLASIGHQRNCPVATEDIHLKKE 431
            |.:|..|....||.:  |....|.|.|..|    .||...:|.|.|                 |.
Human    10 PRTLLSIADILAPRM--VPRAPSAPQLPESGPGPTSPLCALEELTS-----------------KT 55

  Fly   432 LDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYP 496
            ..|..:......||   ..|...:|...       ..||.:::||:||..|:..||:.|....|.
Human    56 FRGLDARALQPSEG---RAGPDALGPGP-------FGRKRRKSRTAFTAQQVLELERRFVFQKYL 110

  Fly   497 DVFARERLAGKIGLPEARIQVWFSNRRAKWRRE-EKLRNQRRTPNSTGASATSSSTSATASLTD- 559
            ....|:.||.::||..|::..||.|||||.:|: |::|                  :..|||..
Human   111 APSERDGLATRLGLANAQVVTWFQNRRAKLKRDVEEMR------------------ADVASLRAL 157

  Fly   560 SPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLG-AGIDSSESPTPIPHI 617
            ||..|  ||..|...|..|.:                   .|| ||.||.      ||:
Human   158 SPEVL--CSLALPEGAPDPGL-------------------CLGPAGPDSR------PHL 189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	22/51 (43%)
LBX2	NP_001269359.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..46		7/23 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..89		6/35 (17%)
		Homeobox	88..141	CDD:278475	22/52 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..198		9/42 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910