DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ey and LBX2

DIOPT Version :9

Sequence 1:NP_001014693.1 Gene:ey / 43812 FlyBaseID:FBgn0005558 Length:898 Species:Drosophila melanogaster
Sequence 2:NP_001269359.1 Gene:LBX2 / 85474 HGNCID:15525 Length:198 Species:Homo sapiens


Alignment Length:254 Identity:67/254 - (26%)
Similarity:90/254 - (35%) Gaps:81/254 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   371 PTSLSEIPISSAPNIASVTAYASGPSLAHS----LSPPNDIESLASIGHQRNCPVATEDIHLKKE 431
            |.:|..|....||.:  |....|.|.|..|    .||...:|.|.|                 |.
Human    10 PRTLLSIADILAPRM--VPRAPSAPQLPESGPGPTSPLCALEELTS-----------------KT 55

  Fly   432 LDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYP 496
            ..|..:......||   ..|...:|...       ..||.:::||:||..|:..||:.|....|.
Human    56 FRGLDARALQPSEG---RAGPDALGPGP-------FGRKRRKSRTAFTAQQVLELERRFVFQKYL 110

  Fly   497 DVFARERLAGKIGLPEARIQVWFSNRRAKWRRE-EKLRNQRRTPNSTGASATSSSTSATASLTD- 559
            ....|:.||.::||..|::..||.|||||.:|: |::|                  :..|||.. 
Human   111 APSERDGLATRLGLANAQVVTWFQNRRAKLKRDVEEMR------------------ADVASLRAL 157

  Fly   560 SPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLG-AGIDSSESPTPIPHI 617
            ||..|  ||..|...|..|.:                   .|| ||.||.      ||:
Human   158 SPEVL--CSLALPEGAPDPGL-------------------CLGPAGPDSR------PHL 189

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eyNP_001014693.1 PAX 98..221 CDD:128645
Homeobox 475..527 CDD:278475 22/51 (43%)
LBX2NP_001269359.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..46 7/23 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 63..89 6/35 (17%)
Homeobox 88..141 CDD:278475 22/52 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..198 9/42 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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