DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and NKX6-2

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_796374.2	Gene:	NKX6-2 / 84504	HGNCID:	19321	Length:	277	Species:	Homo sapiens

Alignment Length:	249	Identity:	60/249 - (24%)
Similarity:	95/249 - (38%)	Gaps:	72/249 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   375 SEIPISSAPNIASVTAY---ASGPSLAHSLSPPNDIESLASI----------GHQRNCPVATEDI 426
            :::|:.:...|:.:...   |:|..|...|...|.:.|.|.:          |:.:  |:|
Human    50 AQLPLGTPHGISDILGRPVGAAGGGLLGGLPRLNGLASSAGVYFGPAAAVARGYPK--PLA---- 108

  Fly   427 HLKKELDGH-----QSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSL 486
                ||.|.     .....|:...:....|.:..|...|...      |.:.:|.:|:..||.:|
Human   109 ----ELPGRPPIFWPGVVQGAPWRDPRLAGPAPAGGVLDKDG------KKKHSRPTFSGQQIFAL 163

  Fly   487 EKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRRE----------------EKLR-- 533
            ||.||:|.|.....|.|||..:|:.|::::|||.|||.|||:.                |||:
Human   164 EKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAVEMASAKKKQDSDAEKLKVG 228

  Fly   534 ----------NQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGG 577
                      |:...|||.....|.....      ..|::|    :|:|...||
Human   229 GSDAEDDDEYNRPLDPNSDDEKITRLLKK------HKPSNL----ALVSPCGGG 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	24/51 (47%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250\|UniProtKB:D3Z4R4	89..142		10/62 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	132..155		5/28 (18%)
		Homeobox	151..204	CDD:306543	24/52 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	210..250		7/39 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910