DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and Sdcbp

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_114192.1	Gene:	Sdcbp / 83841	RGDID:	621497	Length:	300	Species:	Rattus norvegicus

Alignment Length:	200	Identity:	38/200 - (19%)
Similarity:	66/200 - (33%)	Gaps:	76/200 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   359 SWPPRHYSGSWYPTSLSE------IPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQR 417
            ::||   .|:.||....|      :.:|.|....::...:..|:....::.|:.:..:.:
  Rat    40 AFPP---GGNLYPKLYPELSQYMGLSLSEAEICENMPVVSGAPTQGQLVARPSSVNYMVA----- 96

  Fly   418 NCPVATED--------------IHLKKELDGH-----------------QSDETGS------GE- 444
              ||...|              :.|.|:.||.                 |::...|      |:
  Rat    97 --PVTGNDAGIRRAEIKQGIREVILCKDQDGKIGLRLKSVDNGIFVQLVQANSPASLVGLRFGDQ 159

  Fly   445 -----GENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERL 504
                 |||..|.:|       |:|..:||:......|....|      :.||||    |...:..
  Rat   160 VLQINGENCAGWSS-------DKAHKVLKQAFGEKITMTIRD------RPFERT----VTMHKDS 207

  Fly   505 AGKIG 509
            :|.:|
  Rat   208 SGHVG 212

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	8/34 (24%)
Sdcbp	NP_114192.1	Interaction with PDCD6IP. /evidence=ECO:0000250\|UniProtKB:O08992	2..104		13/73 (18%)
		LYPX(n)L motif 1. /evidence=ECO:0000250\|UniProtKB:O08992	3..7
		LYPX(n)L motif 2. /evidence=ECO:0000250\|UniProtKB:O08992	47..51		2/3 (67%)
		LYPX(n)L motif 3. /evidence=ECO:0000250\|UniProtKB:O08992	51..55		0/3 (0%)
		PDZ_signaling	114..193	CDD:238492	17/85 (20%)
		PDZ_signaling	198..271	CDD:238492	5/18 (28%)
		phosphatidylinositol-4, 5-bisphosphate-binding. /evidence=ECO:0000250\|UniProtKB:O00560	252..253
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900