DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ey and Pax4

DIOPT Version :9

Sequence 1:NP_001014693.1 Gene:ey / 43812 FlyBaseID:FBgn0005558 Length:898 Species:Drosophila melanogaster
Sequence 2:NP_113987.1 Gene:Pax4 / 83630 RGDID:620433 Length:349 Species:Rattus norvegicus


Alignment Length:486 Identity:147/486 - (30%)
Similarity:187/486 - (38%) Gaps:217/486 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly    99 SGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRA 163
            |.||||||:||.|||||..|||:||:||..|.|||||||.|:||||||||||||||.||.:.|:.
  Rat     7 SSVNQLGGLFVNGRPLPLDTRQQIVQLAIRGMRPCDISRSLKVSNGCVSKILGRYYRTGVLEPKG 71

  Fly   164 IGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKE 228
            |||||||:||..||::|:|.|.|.|::|||||:.:|..|.:||.|..|||||||||||  |.|::
  Rat    72 IGGSKPRLATPAVVARIAQLKDEYPALFAWEIQRQLCAEGLCTQDKAPSVSSINRVLR--ALQED 134

  Fly   229 QQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSG 293
            |:                                                               
  Rat   135 QR--------------------------------------------------------------- 136

  Fly   294 EGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQ 358
                          |:......|..|.||..:|                   |.|.:|       
  Rat   137 --------------LHWTQLRSPAVLAPALPSP-------------------HSNCEA------- 161

  Fly   359 SWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVAT 423
               ||                              ||                            
  Rat   162 ---PR------------------------------GP---------------------------- 165

  Fly   424 EDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEK 488
                                     :.|.|:                  ||||.|:..|.::|||
  Rat   166 -------------------------HPGTSH------------------RNRTIFSPGQAEALEK 187

  Fly   489 EFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSA 553
            ||:|..|||...|.:||....|||..::||||||||||||:|||:.:.:.|.::........:..
  Rat   188 EFQRGQYPDSVVRGKLAAATSLPEDTVRVWFSNRRAKWRRQEKLKWETQMPGASQDLMVPKDSPG 252

  Fly   554 TASLTDSPNSLSACSSLLSGSAGGPSVSTIN 584
            ..|...||.|:.        ||..|.:..:|
  Rat   253 IISAQQSPGSVP--------SAALPVLEQLN 275

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
eyNP_001014693.1 PAX 98..221 CDD:128645 82/121 (68%)
Homeobox 475..527 CDD:278475 28/51 (55%)
Pax4NP_113987.1 PAX 5..129 CDD:128645 82/121 (68%)
PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381 8..64 43/55 (78%)
RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381 83..131 28/49 (57%)
Homeobox 174..226 CDD:278475 28/51 (55%)
Transcription repression 278..349
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0849
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1152885at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45636
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.920

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