DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and ALX1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_008913.2	Gene:	ALX1 / 8092	HGNCID:	1494	Length:	326	Species:	Homo sapiens

Alignment Length:	320	Identity:	92/320 - (28%)
Similarity:	126/320 - (39%)	Gaps:	65/320 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   388 VTAYASGPSLAHSL-----SPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGEN 447
            |.|:...|...|.:     ||..|......|......|:.||   |.:.:|...|......:|..
Human    50 VQAFGPLPRAEHHVRLERTSPCQDSSVNYGITKVEGQPLHTE---LNRAMDNCNSLRMSPVKGMQ 111

  Fly   448 SNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPE 512
            ..|....:|:..|..   :...|.:|:||:||:.|::.|||.|::||||||:.||:||.:..|.|
Human   112 EKGELDELGDKCDSN---VSSSKKRRHRTTFTSLQLEELEKVFQKTHYPDVYVREQLALRTELTE 173

  Fly   513 ARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGG 577
            ||:||||.|||||||:.|:....::..:...|:...|....|.|.....|:|.|      |:|.|
Human   174 ARVQVWFQNRRAKWRKRERYGQIQQAKSHFAATYDISVLPRTDSYPQIQNNLWA------GNASG 232

  Fly   578 PSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCP 642
            .||.|...|..                 |:|...||..|   |..:|:..
Human   233 GSVVTSCMLPR-----------------DTSSCMTPYSH---SPRTDSSY--------------- 262

  Fly   643 LGVGGHQNT-HHIQSN---------GHAQGHALVPAISPRLNFNSGSFGAM-YSNMHHTA 691
            .|...|||. .|:..|         |...|||.  ...|.....|.|...: .....|||
Human   263 TGFSNHQNQFSHVPLNNFFTDSLLTGATNGHAF--ETKPEFERRSSSIAVLRMKAKEHTA 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
ALX1	NP_008913.2	Homeobox	135..189	CDD:365835	33/53 (62%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	192..326		37/172 (22%)
		OAR	302..320	CDD:367680	3/17 (18%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	306..319		1/12 (8%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910