DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and ZFHX4

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_078997.4	Gene:	ZFHX4 / 79776	HGNCID:	30939	Length:	3616	Species:	Homo sapiens

Alignment Length:	1127	Identity:	215/1127 - (19%)
Similarity:	332/1127 - (29%)	Gaps:	409/1127 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 VVPPWSAGTLIERLPSLEDMAHKDNVIAMRNLPCLGTAGGSGLGGIAGKPSPTMEAVEASTASHP 78
            |:..|...||.:     |...:||:.....|.|.      :.|..|...|.||......|.||..
Human  2172 VIKHWFRNTLFK-----ERQRNKDSPYNFSNPPI------TVLEDIRIDPQPTSLEHYKSDASFS 2225

  Fly    79 HSTS-------------SYFATTYYHLTDDECHSGVNQLGGVFVGGRPLP--------DSTRQKI 122
            ..:|             .:|.|..|. .|||    :.||..|.    .||        .:.|||.
Human  2226 KRSSRTRFTDYQLRVLQDFFDTNAYP-KDDE----IEQLSTVL----NLPTRVIVVWFQNARQKA 2281

  Fly   123 VELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKREC 187
            .:...:.|...|..: .:::|       .||..|.:::.:.   .|..|....:...|:..|::|
Human  2282 RKSYENQAETKDNEK-RELTN-------ERYIRTSNMQYQC---KKCNVVFPRIFDLITHQKKQC 2335

  Fly   188 PSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVS 252
                 ::..|...|:...|.|::.:...:  |.::...          |..|.|..:.:|.
Human  2336 -----YKDEDDDAQDESQTEDSMDATDQV--VYKHCTV----------SGQTDAAKNAAAP---- 2379

  Fly   253 IGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPG 317
                   .||...||   ||.|:.:..|                |.|             ...|.
Human  2380 -------AASSGSGT---STPLIPSPKP----------------EPE-------------KTSPK 2405

  Fly   318 PLEPARAAPLVGQSPNHLGTR--------SSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSL 374
            |..||........||...||:        ||.|.     ..:..|.|.|..||:.......|.|.
Human  2406 PEYPAEKPKQSDPSPPSQGTKPALPLASTSSDPP-----QASTAQPQPQPQPPKQPQLIGRPPSA 2465

  Fly   375 SEIPISSAPNIASVTAYASGPSLAHSLSP------------------------------------ 403
            |:.|:.|:|...|:|      ||.:||.|
Human  2466 SQTPVPSSPLQISMT------SLQNSLPPQLLQYQCDQCTVAFPTLELWQEHQHMHFLAAQNQFL 2524

  Fly   404 -----------------PND--------------IESLASIGHQRNCPVATEDIHLKKELDGHQS 437
                             ||:              :...||..| ...| .|....||::||..:.
Human  2525 HSPFLERPMDMPYMIFDPNNPLMTGQLLGSSLTQMPPQASSSH-TTAP-TTVAASLKRKLDDKED 2587

  Fly   438 DETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARE 502
            :.....||          ||:.:||.|      .:|.||:.|.:|::.|.:::.....|.....:
Human  2588 NNCSEKEG----------GNSGEDQHR------DKRLRTTITPEQLEILYEKYLLDSNPTRKMLD 2636

  Fly   503 RLAGKIGLPEARIQVWFSNRRAKWRREE-----KLRNQRRTPNSTGASATSSS------------ 550
            .:|.::||.:..:||||.|.||:.|:.:     ..::.:|.|.........|:
Human  2637 HIAREVGLKKRVVQVWFQNTRARERKGQFRAVGPAQSHKRCPFCRALFKAKSALESHIRSRHWNE 2701

  Fly   551 -TSATASLTDSPNSLSACSSLLSGSAGGPS-------------------------VSTIN----- 584
             ..|..||..||        |:|...||.|                         .||::
Human  2702 GKQAGYSLPPSP--------LISTEDGGESPQKYIYFDYPSLPLTKIDLSSENELASTVSTPVSK 2758

  Fly   585 -------GLSSPSTLST-------NVNAPTLGAGIDSS-----ESPTPIPHIRPSCTSDNDNGR- 629
                   .|.|||:...       |:|||...||.|.:     |:.:....|..:.|.|..|..
Human  2759 TAELSPKNLLSPSSFKAECSEDVENLNAPPAEAGYDQNKTDFDETSSINTAISDATTGDEGNTEM 2823

  Fly   630 -----QSEDCRRVCSPC-PLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMH 688
                 .|.|.:...||. |..:..........:........|....||.::||.      ....|
Human  2824 ESTTGSSGDVKPALSPKEPKTLDTLPKPATTPTTEVCDDKFLFSLTSPSIHFND------KDGDH 2882

  Fly   689 HTALSMSDSYGAVTPIPSFNHSAVGPLA-PPSPIP----------------------QQGDLTPS 730
            ..:..::|.     |..:.:.|....:| |.||.|                      |..:|...
Human  2883 DQSFYITDD-----PDDNADRSETSSIADPSSPNPFGSSNPFKSKSNDRPGHKRFRTQMSNLQLK 2942

  Fly   731 SLYPCHMTLRPPPM-----------------------APAHHHIVPGDGGRPAGVGLGSGQSANL 772
            .|..|....|.|.|                       |.|.......:.|:|..:..|..:....
Human  2943 VLKACFSDYRTPTMQECEMLGNEIGLPKRVVQVWFQNARAKEKKFKINIGKPFMINQGGTEGTKP 3007

  Fly   773 GASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSAS----------------ANVTPHHTIA 821
            ..:..|..|.            |..|..|..||....:.                |..|....:|
Human  3008 ECTLCGVKYS------------ARLSIRDHIFSKQHISKVRETVGSQLDREKDYLAPTTVRQLMA 3060

  Fly   822 QESC----------------PSPCSSASHFGVAHSSGFSSDP-----ISPAVSSYAHMSYNYASS 865
            |:..                |....|:|..|::..:.:...|     :.|.::..:.:. .:..:
Human  3061 QQELDRIKKASDVLGLTVQQPGMMDSSSLHGISLPTAYPGLPGLPPVLLPGMNGPSSLP-GFPQN 3124

  Fly   866 ANTMTPSSAS----GTSAHVAP 883
            :||:||..|.    .|||..:|
Human  3125 SNTLTPPGAGMLGFPTSATSSP 3146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	24/130 (18%)
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	16/51 (31%)
ZFHX4	NP_078997.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	522..545
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	565..611
		C2H2 Zn finger	615..636	CDD:275368
		C2H2 Zn finger	646..667	CDD:275368
		C2H2 Zn finger	701..718	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1299..1369
		C2H2 Zn finger	1399..1419	CDD:275371
		C2H2 Zn finger	1427..1444	CDD:275371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1474..1525
		C2H2 Zn finger	1543..1567	CDD:275368
		C2H2 Zn finger	1595..1613	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1806..1836
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1854..1903
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1993..2069
		COG5576	2101..2240	CDD:227863	18/78 (23%)
		HOX	2130..2185	CDD:197696	4/17 (24%)
		Homeobox	2229..2282	CDD:278475	15/61 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2334..2356		5/26 (19%)
		PHA02682	2350..>2506	CDD:177464	45/221 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2373..2476		33/150 (22%)
		COG5576	2542..>2664	CDD:227863	36/139 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2552..2609		17/74 (23%)
		Homeobox	2609..2661	CDD:278475	16/51 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2809..2856		9/46 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2874..2930		11/66 (17%)
		Homeobox	2933..2985	CDD:278475	9/51 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3141..3221		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3330..3386
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3492..3511
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	3560..3583
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910