Protein Alignment ey and pax8

DIOPT Version :10

• Sequence 1: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: XP_012814730.1
• Gene: pax8 / 780226
• XenbaseID: XB-GENE-483693
• Length: 467
• Species: Xenopus tropicalis
• Alignment Length: 725
• Identity: 193/725 - (26%)
• Similarity: 250/725 - (34%)
• Gaps: 312/725 - (43%)

  Fly    98 HSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILG-RYYETGSIRP 161
            |.|:|||||.||.|||||:..||:||:|||.|.|||||||.|:||:|||||||| ||||||||||
 Frog    27 HGGLNQLGGAFVNGRPLPEVVRQRIVDLAHQGVRPCDISRQLRVSHGCVSKILGSRYYETGSIRP 91

  Fly   162 RAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQ 226
            ..||||||:|||.:||.||..|||:.|::||||||||||.|.||.||.:||||||||::|....|
 Frog    92 GVIGGSKPKVATPKVVEKIGDYKRQNPTMFAWEIRDRLLAEGVCDNDTVPSVSSINRIIRTKVQQ 156

  Fly   227 KEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNS--SESGGA 289
            .......|...|.|.|.::....:|                           ||..|  |:|.|:
 Frog   157 LFNLPMESCVKSLSPGQTLIPSSAV---------------------------TPPESPHSDSLGS 194

  Fly   290 SNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVG-QSPNHLGTRSSHPQLVHGNHQALQ 353
            :.|..|                               |:| ..|...|.|.            |.
 Frog   195 TYSISG-------------------------------LLGITQPGADGKRK------------LD 216

  Fly   354 QHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRN 418
            ...|:|            ..||                               |:|..|:|..|.
 Frog   217 DSDQES------------CRLS-------------------------------IDSQGSMGISRK 238

  Fly   419 CPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQI 483
                    .|:.|..||.                                             .:
 Frog   239 --------QLRTEAYGHH---------------------------------------------PL 250

  Fly   484 DSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATS 548
            |:||..|:|.|:|:.:                                            :|:|.
 Frog   251 DALECHFQRQHFPESY--------------------------------------------SSSTH 271

  Fly   549 SSTSATA--------SLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTL--GA 603
            |.|....        ::.|..:||::.::.:     |.::||..|.|:.|.||    |.|:  .|
 Frog   272 SKTEQALYTLPLLNNAMDDGKSSLTSTNTTI-----GRNLSTHQGYSALSELS----AFTIKQEA 327

  Fly   604 GIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPA 668
            ...||.|.||                     ..:|||..|.
 Frog   328 SDSSSASSTP---------------------SSLCSPTFLD------------------------ 347

  Fly   669 ISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAP--PSPIPQ-QGDLTPS 730
            :.|   .:||.....:|...|.|    ..||..|...:.....||...|  |..||. ||:...|
 Frog   348 LQP---ISSGCSAPSFSAFSHPA----SVYGQFTSHMASGRDVVGSTLPGYPPHIPSGQGNYASS 405

  Fly   731 SLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANLG-------ASCSGSGYEVLSAYA 788
            ::         ..|..|        ||..:|.....|..|..|       :|..||.|...||..
 Frog   406 AI---------AGMVAA--------GGDYSGNAYSHGAYAAYGESWRFPSSSLLGSPYYYSSATR 453

  Fly   789 LPPPPMASSS 798
            ..|||..:.:
 Frog   454 TAPPPTTAGA 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	90/123 (73%)
		Homeodomain	473..528	CDD:459649	7/54 (13%)
pax8	XP_012814730.1	PAX	26..151	CDD:128645	90/123 (73%)
		Pax2_C	355..465	CDD:463563	32/130 (25%)