Protein Alignment ey and pax8

DIOPT Version :9

• Sequence 1: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: XP_001339893.5
• Gene: pax8 / 60637
• ZFINID: ZDB-GENE-001030-3
• Length: 448
• Species: Danio rerio
• Alignment Length: 688
• Identity: 183/688 - (26%)
• Similarity: 252/688 - (36%)
• Gaps: 282/688 - (40%)

  Fly    98 HSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPR 162
            |.|:|||||:||.|||||:..||:||::||.|.|||||||.|:||:||||||||||||||||:|.
Zfish     9 HGGLNQLGGMFVNGRPLPEVIRQRIVDMAHQGVRPCDISRQLRVSHGCVSKILGRYYETGSIKPG 73

  Fly   163 AIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQK 227
            .||||||:|||.:||.||::|||:.|::||||||||||.|.||..|.:||||||||::|.    |
Zfish    74 VIGGSKPKVATPKVVEKIAEYKRQNPTMFAWEIRDRLLAEGVCDGDTVPSVSSINRIIRT----K 134

  Fly   228 EQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNS 292
            .||                                                 |.|.
Zfish   135 VQQ-------------------------------------------------PFNL--------- 141

  Fly   293 GEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQ 357
                                     ||:..      |.||.|....||          |:...:.
Zfish   142 -------------------------PLDTK------GLSPGHTLIPSS----------AVTPPES 165

  Fly   358 QSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVA 422
               |.....||.|          |...:..:|...:.....|..|            .|.:|
Zfish   166 ---PQSDSLGSTY----------SINGLLGITQTTADGKRGHDDS------------DQESC--- 202

  Fly   423 TEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLE 487
                       .|..|..|||      |||.....||                 .|.:..:|.
Zfish   203 -----------RHSVDSQGSG------GGARKQLRTE-----------------HFPSAALDC-- 231

  Fly   488 KEFERTHYPDVFARERLAGKI--------GLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGA 544
             .|||.:..|.|::.:...::        ||.|.:                            ||
Zfish   232 -GFERHYSSDSFSQSKAEQQLYPLALMNPGLDEGK----------------------------GA 267

  Fly   545 SATSSSTSA-------TASLTDSP-----------NSLSACSSLLSGSAGGPSVSTINGLSSPST 591
            |:.|.:.:|       |.:|...|           ||||....::||||    ...::.:||||:
Zfish   268 SSISRNLAAHQGYAVVTEALQPLPLCLKQEVSPEVNSLSPSPHIISGSA----FLDLSAISSPSS 328

  Fly   592 --LSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHI 654
              ::::..:..|..|..|.....|:            :|:.|       ||..:.
Zfish   329 APVASSCGSAHLSHGFSSFSHHAPV------------HGQFS-------SPSLMA---------- 364

  Fly   655 QSNGHAQGHALVPAISPRL-----NFNSGSFGAMYSNMHHTALSMS-DSYGAVTPIPSFNHSAVG 713
               |.....:::|...|.:     .|:|.:...|.|...:|..|.| .:|.:.:....|.:|::
Zfish   365 ---GREVASSMLPGYPPHIPTAQTGFSSSTIAGMVSAPEYTGQSYSHPAYSSYSEAWRFTNSSI- 425

  Fly   714 PLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHI 751
             |..|              |......||||.|.|:.|:
Zfish   426 -LGSP--------------YYYSSATRPPPPAAAYDHL 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	87/122 (71%)
		Homeobox	475..527	CDD:278475	10/59 (17%)
pax8	XP_001339893.5	PAX	8..132	CDD:128645	87/122 (71%)
		Pax2_C	343..437	CDD:289189	23/141 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910