DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and ALX4

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_068745.2	Gene:	ALX4 / 60529	HGNCID:	450	Length:	411	Species:	Homo sapiens

Alignment Length:	443	Identity:	119/443 - (26%)
Similarity:	166/443 - (37%)	Gaps:	135/443 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 ATPLNSSESG-GASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSH 341
            ||||   ||| ||..|         :.|.:    ...:.|.|..|.:..|
Human    74 ATPL---ESGAGARGS---------FNKFQ----PQPSTPQPQPPPQPQP--------------- 107

  Fly   342 PQLVHGNHQALQQHQQQSWPP-------RHYSGSWYPTSLSEIPISSAPNIAS--VTAYASGPSL 397
                       ||.|.|..||       :..:....|....::...|:.:.|:  |..||...||
Human   108 -----------QQQQPQPQPPAQPHLYLQRGACKTPPDGSLKLQEGSSGHSAALQVPCYAKESSL 161

  Fly   398 AHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQ 462
            .....||:.    .::|...:. ::.::..:|...|...||.....|..:|.   ||
Human   162 GEPELPPDS----DTVGMDSSY-LSVKEAGVKGPQDRASSDLPSPLEKADSE---SN-------- 210

  Fly   463 ARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWR 527
                 |.|.:||||:||:.|::.|||.|::||||||:|||:||.:..|.|||:||||.|||||||
Human   211 -----KGKKRRNRTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWR 270

  Fly   528 REEKL--RNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPS 590
            :.|:.  ..|.||..||.......:.:...:...:|:.|..                 ||.:||
Human   271 KRERFGQMQQVRTHFSTAYELPLLTRAENYAQIQNPSWLGN-----------------NGAASP- 317

  Fly   591 TLSTNVNAPTLGAGIDSSESPTPI---PHIRPSCTSDNDNGRQS-EDCRRVCSPCPLGVGGHQNT 651
                   .|......|    |.|.   ||..|.     .:|..| .|...|.     |.|.|...
Human   318 -------VPACVVPCD----PVPACMSPHAHPP-----GSGASSVTDFLSVS-----GAGSHVGQ 361

  Fly   652 HHIQSNGHAQGHALVPAISPRLN---------FNSGSFGA--MYSNMHHTALS 693
            .|:   |...|.|   ::||.||         ..:.|..|  |.:..|..|:|
Human   362 THM---GSLFGAA---SLSPGLNGYELNGEPDRKTSSIAALRMKAKEHSAAIS 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	33/51 (65%)
ALX4	NP_068745.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	75..145		22/111 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	184..219		12/50 (24%)
		Homeobox	218..270	CDD:278475	33/51 (65%)
		OAR	387..404	CDD:281777	3/16 (19%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	391..404		3/12 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910