DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and alx1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001038539.1	Gene:	alx1 / 565176	ZFINID:	ZDB-GENE-050419-191	Length:	320	Species:	Danio rerio

Alignment Length:	325	Identity:	88/325 - (27%)
Similarity:	127/325 - (39%)	Gaps:	115/325 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   380 SSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGE 444
            |...|.:|||..|           |...||  |:....||.    .:.:.....|  .|:|...|
Zfish    61 SPCDNQSSVTYCA-----------PKSEES--SLHAMENCC----SLRVSPATSG--PDKTDLDE 106

  Fly   445 -GENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKI 508
             ||..:   ||:.::           |.:|:||:||:.|::.|||.|::||||||:.||:||.:.
Zfish   107 LGEKCD---SNVSSS-----------KKRRHRTTFTSAQLEELEKVFQKTHYPDVYVREQLAMRT 157

  Fly   509 GLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSG 573
            .|.|||:||||.|||||||:.|:....::         ..|..:||..::..|.:
Zfish   158 ELTEARVQVWFQNRRAKWRKRERYGQIQQ---------AKSHFAATYDISMLPRT---------- 203

  Fly   574 SAGGPSVSTINGLSSPSTLSTNV-NAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRV 637
                         .|.|.:|.|: ..|:.|:.:.||   ..||...|.|               |
Zfish   204 -------------DSYSQISNNLWTGPSAGSSVVSS---CMIPRGSPPC---------------V 237

  Fly   638 CSPCP----------LGVGGHQ----NTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMH 688
            .||.|          :|...||    ..:|:..|                ||.:.|..|..:|.|
Zfish   238 TSPYPHSPRAAEHGYVGFPNHQQNQFGVNHVSLN----------------NFFADSLLASSANSH 286

Fly 689 688
Zfish 287 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
alx1	NP_001038539.1	Homeobox	123..176	CDD:278475	32/52 (62%)
		Transactivation domain. /evidence=ECO:0000250\|UniProtKB:Q63087	180..320		31/173 (18%)
		OAR	296..313	CDD:281777
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	300..313
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910