DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and dmbx1b

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001017625.1	Gene:	dmbx1b / 550288	ZFINID:	ZDB-GENE-050417-97	Length:	369	Species:	Danio rerio

Alignment Length:	341	Identity:	90/341 - (26%)
Similarity:	128/341 - (37%)	Gaps:	113/341 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 RKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEK-- 531
            ||.:|:||:||..|:::|||.|::||||||..|||||....|||||:||||.|||||:|::::
Zfish    64 RKQRRSRTAFTAQQLEALEKTFQKTHYPDVVMRERLAMCTNLPEARVQVWFKNRRAKFRKKQRSL 128

  Fly   532 LRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGL-SSPS---TL 592
            .:.|.:.....|...........|    .|....|..|.|.|          .|| |:||   ..
Zfish   129 QKEQLQRLKEAGTEGAQDEGKEEA----PPVEAQAPPSPLDG----------RGLTSAPSCELNE 179

  Fly   593 STNVNAPTLGAGIDSSESPT-----------PIPHIRPSCTSDNDN------GRQSEDCRRVCSP 640
            ..||.:|........:|..|           .|....|...:|:.:      ..:|:|
Zfish   180 EVNVTSPEQSGAESGAEDTTDREDEPLSIKDEIKEAGPPLMTDDSSPSYKPLSPKSDD------- 237

  Fly   641 CPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIP 705
                                      |.:||.|..:||            |::.|:|| |.:|:.
Zfish   238 --------------------------PLVSPALPSSSG------------AVAQSNSY-ASSPLS 263

  Fly   706 SFN----------------HSAVGPLAPPSPIPQQG----DLTPSSLYPC---HMTLRPPPM--- 744
            .|.                |.....:..||.:|..|    ..:|....||   :.||.....
Zfish   264 LFRLQEQFRQHMAATNNLMHYPAFDVTAPSSLPYLGVNVNMASPLGSLPCQPYYQTLTQAQQMWS 328

  Fly   745 APAHHHIVPGDGGRPA 760
            :|    ::.|.||.||
Zfish   329 SP----LLQGSGGLPA 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	34/51 (67%)
dmbx1b	NP_001017625.1	Homeobox	69..122	CDD:278475	34/52 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..253		30/187 (16%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	346..359
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940