DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and pitx2

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001017227.1	Gene:	pitx2 / 549981	XenbaseID:	XB-GENE-482492	Length:	345	Species:	Xenopus tropicalis

Alignment Length:	359	Identity:	104/359 - (28%)
Similarity:	149/359 - (41%)	Gaps:	112/359 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 EPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPN 384
            ||.....|||   :.|.|.|||.|..|..||..|.|.||....:|                ..|.
Frog     6 EPLHLDHLVG---SKLATASSHHQHHHQQHQQHQHHHQQHHHQQH----------------QQPQ 51

  Fly   385 IASVTAYASGPSLAHSLSPPNDIESLASIGHQRN--CPVATEDIHLKKELDGHQSDETGSGEG-- 445
            ..:||                 :.|:||...||:  |         |..|:.|...:|.|.|.
Frog    52 PQAVT-----------------LVSMASSLGQRSGEC---------KARLEVHTISDTSSPEAAD 90

  Fly   446 ENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGL 510
            ::.:..:.|..::.||.::   |::.:|.||.||:.|:..||..|:|..|||:..||.:|....|
Frog    91 KDKSHQSKNEDSSTDDPSK---KKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNL 152

  Fly   511 PEARIQVWFSNRRAKWRREEKLRNQRRT-------PNSTG----------------------ASA 546
            .|||::|||.|||||||:.|  |||:..       |...|                      .||
Frog   153 TEARVRVWFKNRRAKWRKRE--RNQQAELCKNGFGPQFNGLMQPYDDMYPSYSYNNWAAKGLTSA 215

  Fly   547 TSSSTS------------ATASLTDSPNSLSACS-------SLLSG--SAGGPSVSTINGLSSPS 590
            :.|:.|            ::.|:..||||:|:.|       |.::|  .:|..|::.:|.||:|
Frog   216 SLSTKSFPFFNSMNVNPLSSQSMFSSPNSISSMSMSSGMVPSAVTGVPGSGLNSLNNLNNLSNP- 279

  Fly   591 TLSTNVNAPTLGAGIDSSESPTPIPHI-RPSCTS 623
              |.|...||...   ....||| |:: |.:|.|
Frog   280 --SLNTAVPTSAC---PYAPPTP-PYVYRDTCNS 307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	27/51 (53%)
pitx2	NP_001017227.1	XRCC4	<84..144	CDD:284132	19/62 (31%)
		Homeobox	117..169	CDD:278475	27/51 (53%)
		OAR	303..320	CDD:281777	2/5 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910