DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and hoxb3

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001015971.1	Gene:	hoxb3 / 548725	XenbaseID:	XB-GENE-482576	Length:	386	Species:	Xenopus tropicalis

Alignment Length:	449	Identity:	110/449 - (24%)
Similarity:	167/449 - (37%)	Gaps:	117/449 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 PLVGQSPNHLGTRSSHPQLVHGNHQ------ALQQ--HQQQSWPPRHYSGSWYPTSLS---EIPI 379
            |....|..:.|.:.|.|...|.:::      :||.  |.......::.:||....:||   ..|:
Frog    17 PYQAGSLGYEGPQQSFPTSSHMDNEFQRSSCSLQSLGHSGPLVKAKNLNGSCMRPNLSSEQSQPL 81

  Fly   380 SSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKE--LDGHQSDETGS 442
            |...|.:|.|..:|..:   |||.|:..:|.||     ..|.:.:.....||  .:..|.....:
Frog    82 SPTANPSSNTNSSSSQA---SLSKPSPAKSQAS-----GSPASKQIFPWMKESRQNSKQKSSPPA 138

  Fly   443 GEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGK 507
            ...|:..|..|..|::..           :|.||::|:.|:..|||||....|.....|..:|..
Frog   139 PAAESCGGDRSPPGSSAS-----------KRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANL 192

  Fly   508 IGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLS 572
            :.|.|.:|::||.|||.|:::::|::..             ||:|..||.|.:| .||     :.
Frog   193 LNLSERQIKIWFQNRRMKYKKDQKVKGM-------------SSSSGGASPTSTP-PLS-----MQ 238

  Fly   573 GSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRV 637
            .|||        .|.|..:::.|..||          ||.|.           :...|:...:..
Frog   239 SSAG--------FLGSMHSMTANYEAP----------SPPPF-----------NKSHQNAYYQNP 274

  Fly   638 CSPCP----LGVGGHQNTHH-IQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDS 697
            ...||    .|....:..|| :|.||.|.       :||.:..:....|..|          .||
Frog   275 GKGCPSQQKYGNTAAEYDHHGLQGNGGAY-------VSPNMQGSPVYVGGNY----------VDS 322

  Fly   698 YGAV-TPIPSFNHSAVGPL------APPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHH 749
            ..|. .|:...||.|..|.      |||.|..|..  .|...:|.:..|      .|||
Frog   323 VPAQGPPLYGLNHLAHQPTNMDYNGAPPMPASQHH--APCDPHPTYTEL------SAHH 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	21/51 (41%)
hoxb3	NP_001015971.1	Homeobox	160..212	CDD:306543	21/51 (41%)
hoxb3	NP_001015971.1	DUF4074	325..384	CDD:315871	17/57 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910