DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and lhx8

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	XP_012816489.1	Gene:	lhx8 / 548653	XenbaseID:	XB-GENE-494997	Length:	385	Species:	Xenopus tropicalis

Alignment Length:	478	Identity:	98/478 - (20%)
Similarity:	156/478 - (32%)	Gaps:	188/478 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   230 QSTGSGS---SSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASN 291
            ::|.|||   .....|..:....||             |..||    ::|.| ||.|.|.|||
Frog     4 RTTASGSELWQPPGLGQGVPTPRSV-------------RSFLS----VLQFA-PLMSEECGGA-- 48

  Fly   292 SGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQ 356
                                            |.|: |:|      |.|....|.|:..|.....
Frog    49 --------------------------------ALPM-GRS------RKSEGTPVQGSPGAAMDED 74

  Fly   357 QQSWPPRHYSGSWYPTSLSEIPI----SSAPNIASVTAYASGPSLAHS---------LSPPND-- 406
                            |.|.:|:    ||:|:.........|.|:..:         |...||
Frog    75 ----------------SCSSVPLSPVSSSSPHSMPAAGLNQGKSVCSNCGLEIVDKYLLKVNDLC 123

  Fly   407 --IESLA------SIGHQRNCPVATEDIHLKKELDG---------------HQSD---------- 438
              :..|:      |:|...:|.:..:||:.|  ||.               |.:|
Frog   124 WHVRCLSCSVCRTSLGRHTSCYIKDKDIYCK--LDYFRRYGTRCSRCGRHIHATDWVRRAKGNVY 186

  Fly   439 ------------ETGSGEG------------------ENSNGGASNIGNTEDDQARLILKRKL-- 471
                        :..:||.                  :|......| ||....:..|:.::.:
Frog   187 HLACFACYSCKRQLSTGEEFALVEEKVLCRVHYDCMLDNLKRAVEN-GNRVSVEGALLTEQDINQ 250

  Fly   472 ----QRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKL 532
                :|.|||||.||:..::.:|.:.:.||....::|:.:.||....|||||.|.||:.::..
Frog   251 PKPAKRARTSFTADQLQVMQAQFAQDNNPDAQTLQKLSERTGLSRRVIQVWFQNCRARHKKHV-- 313

  Fly   533 RNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVN 597
                 :||.   |:|:..|:...|.. ||..|...:........||.::.::..       .:.:
Frog   314 -----SPNH---SSTTPVTTVQPSRL-SPPMLEEMTYSAYVPQDGPMLTALHSY-------MDAH 362

  Fly   598 APTLGAGIDS----SESPTPIPH 616
            :|| ..|:.|    |.:..||.|
Frog   363 SPT-ALGLQSLLPHSMTQLPISH 384

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	21/51 (41%)
lhx8	XP_012816489.1	LIM1_Lhx7_Lhx8	103..158	CDD:188767	12/56 (21%)
		LIM2_Lhx7_Lhx8	165..219	CDD:188769	4/53 (8%)
		Homeobox	258..311	CDD:365835	21/52 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030