DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and PRRX1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_073207.1	Gene:	PRRX1 / 5396	HGNCID:	9142	Length:	245	Species:	Homo sapiens

Alignment Length:	218	Identity:	71/218 - (32%)
Similarity:	104/218 - (47%)	Gaps:	45/218 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   395 PSLAHSLSPPNDIESLASIGHQRNCPVA-TEDIHLKKELDGHQSDETGSGEGEN---SNGGASNI 455
            |:|...|..|.::::|.:   ::|..|: ..|:....::...|:||.....|.:   |.|..|..
Human    13 PALGGRLDSPGNLDTLQA---KKNFSVSHLLDLEEAGDMVAAQADENVGEAGRSLLESPGLTSGS 74

  Fly   456 GNTEDDQARL----ILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQ 516
            ...:.|..:|    ..|||.:||||:|.:.|:.:||:.||||||||.|.||.||.::.|.|||:|
Human    75 DTPQQDNDQLNSEEKKKRKQRRNRTTFNSSQLQALERVFERTHYPDAFVREDLARRVNLTEARVQ 139

  Fly   517 VWFSNRRAKWRREEK--LRNQ---------------------RRTPNST-----------GASAT 547
            |||.|||||:||.|:  |.|:                     |..|..|           .|.||
Human   140 VWFQNRRAKFRRNERAMLANKNASLLKSYSGDVTAVEQPIVPRPAPRPTDYLSWGTASPYSAMAT 204

  Fly   548 SSSTSATASLTDSPNSLSACSSL 570
            .|:|.|..|.....|..::.::|
Human   205 YSATCANNSPAQGINMANSIANL 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
PRRX1	NP_073207.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22		3/8 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..103		13/39 (33%)
		Homeobox	99..151	CDD:395001	31/51 (61%)
		OAR	219..235	CDD:397759	2/9 (22%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	222..235		1/6 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910