DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Sdcbp

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001091697.1	Gene:	Sdcbp / 53378	MGIID:	1337026	Length:	299	Species:	Mus musculus

Alignment Length:	198	Identity:	38/198 - (19%)
Similarity:	64/198 - (32%)	Gaps:	76/198 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   361 PPRHYSGSWYPTSLSE------IPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNC 419
            ||   .|:.||....|      :.::.|....|:...:..|:....::.|:.:..:.:
Mouse    41 PP---DGNLYPKLYPELSQYMGLSLNEAEICESMPMVSGAPAQGQLVARPSSVNYMVA------- 95

  Fly   420 PVATED--------------IHLKKELDGH-----------------QSDETGS------GE--- 444
            ||...|              :.|.|:.||.                 |::...|      |:
Mouse    96 PVTGNDAGIRRAEIKQGIREVILCKDQDGKIGLRLKSIDNGIFVQLVQANSPASLVGLRFGDQVL 160

  Fly   445 ---GENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAG 506
               |||..|.:|       |:|..:||:......|....|      :.||||    |...:..:|
Mouse   161 QINGENCAGWSS-------DKAHKVLKQAFGEKITMTIRD------RPFERT----VTMHKDSSG 208

  Fly   507 KIG 509
            .:|
Mouse   209 HVG 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	9/35 (26%)
Sdcbp	NP_001091697.1	Interaction with PDCD6IP. /evidence=ECO:0000269\|PubMed:22660413	2..103		13/71 (18%)
		LYPX(n)L motif 1. /evidence=ECO:0000305\|PubMed:22660413	3..7
		LYPX(n)L motif 2. /evidence=ECO:0000305\|PubMed:22660413	46..50		2/3 (67%)
		LYPX(n)L motif 3. /evidence=ECO:0000305\|PubMed:22660413	50..54		0/3 (0%)
		PDZ_signaling	113..192	CDD:238492	17/85 (20%)
		PDZ_signaling	197..270	CDD:238492	6/19 (32%)
		phosphatidylinositol-4, 5-bisphosphate-binding. /evidence=ECO:0000250\|UniProtKB:O00560	251..252
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900