DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and PRRX2

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_057391.1	Gene:	PRRX2 / 51450	HGNCID:	21338	Length:	253	Species:	Homo sapiens

Alignment Length:	223	Identity:	75/223 - (33%)
Similarity:	104/223 - (46%)	Gaps:	37/223 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   392 ASGP----------SLAHSLSPPNDIESLASIGHQRNCPVATEDIH---LKKELDGHQSDETGSG 443
            |.||          |::|.|    |:|.:|:.|.....|.|..:..   .::...|....|....
Human    25 ALGPGDCAQARKNFSVSHLL----DLEEVAAAGRLAARPGARAEAREGAAREPSGGSSGSEAAPQ 85

  Fly   444 EGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKI 508
            :||..:.|..:....         |:|.:||||:|.:.|:.:||:.||||||||.|.||.||.::
Human    86 DGECPSPGRGSAAKR---------KKKQRRNRTTFNSSQLQALERVFERTHYPDAFVREELARRV 141

  Fly   509 GLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSS-STSATASLTDSPNSLSACSSLLS 572
            .|.|||:||||.|||||:|     ||:|....|..||...| |..|......:|...:.....||
Human   142 NLSEARVQVWFQNRRAKFR-----RNERAMLASRSASLLKSYSQEAAIEQPVAPRPTALSPDYLS 201

  Fly   573 GSAGGPSVSTI----NGLSSPSTLSTNV 596
            .:|..| .||:    .|.|.|:|...|:
Human   202 WTASSP-YSTVPPYSPGSSGPATPGVNM 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
PRRX2	NP_057391.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..113		14/66 (21%)
		Homeobox	109..161	CDD:395001	32/56 (57%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	230..243
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910