Protein Alignment ey and PAX1

DIOPT Version :10

• Sequence 1: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: NP_006183.2
• Gene: PAX1 / 5075
• HGNCID: 8615
• Length: 534
• Species: Homo sapiens
• Alignment Length: 439
• Identity: 156/439 - (35%)
• Similarity: 193/439 - (43%)
• Gaps: 132/439 - (30%)

  Fly    45 LP-CLGTAGG--SGLGGIAGKPSPTMEAVEASTASHP-HSTSSYFATTYYHLTDDECHSGVNQLG 105
            || ||...||  ..|...|| |||          .|| |..:...|..   |..::.:..|||||
Human    56 LPLCLSRGGGGAQALPDCAG-PSP----------GHPGHPGARQLAGP---LAMEQTYGEVNQLG 106

  Fly   106 GVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPR 170
            ||||.|||||::.|.:|||||..|.|||||||.|:||:|||||||.||.|||||.|.||||||||
Human   107 GVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPR 171

  Fly   171 VATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRN----LA------A 225
            |.|..||..|..||:..|.|||||||||||.:.||...|:||||||:|:|||    ||      |
Human   172 VTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGSLAQPGPYEA 236

  Fly   226 QKEQQS--------------------TGS--GSSSTSAGNS--ISAKVSVSIGGNVSNV------ 260
            .|:..|                    ||:  ||.....|.:  :|...|.....:|||:
Human   237 SKQPPSQPTLPYNHIYQYPYPSPVSPTGAKMGSHPGVPGTAGHVSIPRSWPSAHSVSNILGIRTF 301

  Fly   261 ------ASGSRGTLSSS-----TDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRL------- 307
                  .:||.||..|.     ..:.:||.|        |:.:..|.|:.|:...::.
Human   302 MEQTGALAGSEGTAYSPKMEDWAGVNRTAFP--------ATPAVNGLEKPALEADIKYTQSASTL 358

  Fly   308 -------------LNTQH-----------AAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGN 348
                         .:.||           |.|| |..||:..||   :|...|.      .|||.
Human   359 SAVGGFLPACAYPASNQHGVYSAPGGGYLAPGP-PWPPAQGPPL---APPGAGV------AVHGG 413

  Fly   349 HQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSA-PNIASVTAYASGPS 396
            ..|.....:            :|:....:|..:| |...|| ||...||
Human   414 ELAAAMTFK------------HPSREGSLPAPAARPRTPSV-AYTDCPS 449

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	83/122 (68%)
		Homeodomain	473..528	CDD:459649
PAX1	NP_006183.2	PAX	98..225	CDD:238076	86/126 (68%)
		PAI subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	101..157		40/55 (73%)
		RED subdomain. /evidence=ECO:0000255|PROSITE-ProRule:PRU00381	176..224		29/47 (62%)
		PHA03247	<212..517	CDD:223021	63/269 (23%)
		PRK07003	<402..>518	CDD:235906	16/67 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	424..480		10/27 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	492..511