DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Nobox

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001178942.1	Gene:	Nobox / 502759	RGDID:	1563929	Length:	524	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	135/576 - (23%)
Similarity:	190/576 - (32%)	Gaps:	192/576 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   311 QHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLS 375
            |...|| |.:|   ||||...|:.|   ||.|:...|..           |....||........
  Rat    25 QDTEGP-PQDP---APLVQGDPDKL---SSLPRAGLGKR-----------PLSKTSGDCIDADTC 71

  Fly   376 EIPISSAPNIASVTAYASGPSL----AHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQ 436
            .:..:.:|.:.|......|.||    |.::.|     |:::...|...|:...:..|||
  Rat    72 RVHTAPSPAVCSPKPQKKGSSLQEKKAETVKP-----SMSAGPGQVPNPLNFRERDLKK------ 125

  Fly   437 SDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFAR 501
                                  |..:|....::|   .||.:.:||::.||:.|:..||||...|
  Rat   126 ----------------------EPLEATCQFRKK---TRTLYRSDQLEELERIFQEDHYPDSDKR 165

  Fly   502 ERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSS--TSATASLTDSPNSL 564
            ..:|..:|:...||.|||.|||||||:.||| |::...|.......:||  .||...|...|..|
  Rat   166 HEIAQMVGVTPQRIMVWFQNRRAKWRKVEKL-NEKEDNNGPAPPRANSSQCRSAPELLGPMPTDL 229

  Fly   565 SACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSE---------SPTPIPHIRPS 620
            .      .|..  |..:.::|.:.|..|.|:....|.....:|:|         ||.||
  Rat   230 E------PGPV--PPENILDGFTEPPVLLTSDQTLTSSQHNESAERVAVTPPLLSPPPI------ 280

  Fly   621 CTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNS-------G 678
                          ||...|.||              |..|...::|.:......:|       |
  Rat   281 --------------RRTNLPLPL--------------GPFQAPQVLPPLRDVPGSDSIYKDKPCG 317

  Fly   679 SFGA------MYSNMHHTALSMSDSYGAVTPIPSFN-------------HSAVGPLAPPSPIPQQ 724
            |:|.      :|||:....   ...|.|...:.||.             .|.| |..||.|:|
  Rat   318 SWGTSITSPPIYSNLEDMG---PQDYQASNQLGSFQLTQAPQTPLFPPLQSQV-PYLPPFPLP-- 376

  Fly   725 GDLTPSSLYPCHMTLRPPPMAPAHHHI------VPGDGGRPAGVGLGSGQSANLGASCSGSGYEV 783
               .||          |.|..|....:      :.||..:....|..|||.. |..:...:|...
  Rat   377 ---IPS----------PLPFLPPEDSLFSFPFGLNGDSSQDYYPGPQSGQIL-LQPTAGNTGPGP 427

  Fly   784 LSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQ---------ESCPSPCS 830
            .|.:.||.||..                   .|||....         :..|:||:
  Rat   428 WSGHCLPEPPFP-------------------RPHHPQGHPLGAEGYFPDLFPTPCA 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	24/51 (47%)
Nobox	NP_001178942.1	COG5576	82..>192	CDD:227863	40/145 (28%)
Nobox	NP_001178942.1	Homeobox	138..191	CDD:278475	24/52 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910