DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and MSX2

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_002440.2	Gene:	MSX2 / 4488	HGNCID:	7392	Length:	267	Species:	Homo sapiens

Alignment Length:	264	Identity:	68/264 - (25%)
Similarity:	97/264 - (36%)	Gaps:	70/264 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 AGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIP 378
            ||||| .|..|.   |.:.......||.|..|    :||...::   ||:         ..|.:|
Human    22 AGPGP-GPGGAE---GAAEERRVKVSSLPFSV----EALMSDKK---PPK---------EASPLP 66

  Fly   379 ISSA---PNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDET 440
            ..||   ..:..:.....|...|||..|                        |.|..      ||
Human    67 AESASAGATLRPLLLSGHGAREAHSPGP------------------------LVKPF------ET 101

  Fly   441 GSGEGENSNGGAS---NIGNTEDDQARL------ILKRKLQRN-RTSFTNDQIDSLEKEFERTHY 495
            .|.:.|||..||:   ..|........:      :.|.|..|. ||.||..|:.:||::|.:..|
Human   102 ASVKSENSEDGAAWMQEPGRYSPPPRHMSPTTCTLRKHKTNRKPRTPFTTSQLLALERKFRQKQY 166

  Fly   496 PDVFARERLAGKIGLPEARIQVWFSNRRAKWRR-----EEKLRNQRR--TPNSTGASATSSSTSA 553
            ..:..|...:..:.|.|.::::||.|||||.:|     .|||:...:  .|:|.......||...
Human   167 LSIAERAEFSSSLNLTETQVKIWFQNRRAKAKRLQEAELEKLKMAAKPMLPSSFSLPFPISSPLQ 231

  Fly   554 TASL 557
            .||:
Human   232 AASI 235

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	19/51 (37%)
MSX2	NP_002440.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..71		19/68 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..147		4/30 (13%)
		Homeobox	145..199	CDD:365835	19/53 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910