Protein Alignment ey and pax3

DIOPT Version :10

• Sequence 1: NP_001014693.1
• Gene: ey / 43812
• FlyBaseID: FBgn0005558
• Length: 898
• Species: Drosophila melanogaster
• Sequence 2: XP_012825755.1
• Gene: pax3 / 448464
• XenbaseID: XB-GENE-482740
• Length: 486
• Species: Xenopus tropicalis
• Alignment Length: 778
• Identity: 205/778 - (26%)
• Similarity: 281/778 - (36%)
• Gaps: 353/778 - (45%)

  Fly   101 VNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIG 165
            ||||||||:.|||||:..|.||||:||.|.|||.|||.|:||:|||||||.||.|||||||.|||
 Frog    39 VNQLGGVFINGRPLPNHIRHKIVEMAHHGIRPCVISRQLRVSHGCVSKILCRYQETGSIRPGAIG 103

  Fly   166 GSKPR-VATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQ 229
            ||||: |.|.||..||.::||:.|.:|:|||||:||::.||..:.:||||||:|:||
 Frog   104 GSKPKQVTTPEVEKKIEEFKRDNPGMFSWEIRDKLLKDGVCDRNTVPSVSSISRILR-------- 160

  Fly   230 QSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGE 294
                                                                        |..|:
 Frog   161 ------------------------------------------------------------SKFGK 165

  Fly   295 GSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQS 359
            |.|::...::                                                 :.|::|
 Frog   166 GDEEDIELDR-------------------------------------------------KEQEES 181

  Fly   360 WPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATE 424
                                                                             
 Frog   182 ----------------------------------------------------------------- 181

  Fly   425 DIHLKKELDGHQSDET-GSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEK 488
            :...|..:||...:.. .|.|.|.        |:..|.:..|.||||.:|:||:||.:|::.||:
 Frog   182 EKRAKHSIDGILRERAPASPESEE--------GSDIDSEPDLPLKRKQRRSRTTFTAEQLEELER 238

  Fly   489 EFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSA 553
            .||||||||::.||.||.:..|.|||:|||||||||:||::            .||
 Frog   239 AFERTHYPDIYTREELAQRAKLTEARVQVWFSNRRARWRKQ------------AGA--------- 282

  Fly   554 TASLTDSPNSLSACSSLLSGS---AGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIP 615
                    |.|.|.:.|:.|:   |..|::.|..       ||            ::|..||.|
 Frog   283 --------NQLMAFNHLIPGAFPPAAMPALPTYQ-------LS------------ETSYQPTSI- 319

  Fly   616 HIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSF 680
               |...||..|        .|..|.||                          .|
 Frog   320 ---PQAVSDPSN--------TVHRPQPL--------------------------PP--------- 338

  Fly   681 GAMYSNMHHTALSMSDSYGAVTPIPSFNH---SAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPP 742
                |::|.::|..:....:...:||..|   |......|||        .||:
 Frog   339 ----SSVHQSSLPSNPESSSAYCLPSGRHGFSSYTDSFVPPS--------GPSN----------- 380

  Fly   743 PMAPAHHHIVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPP------PPMASSSAAD 801
            ||.||     .|:|..|..:||    ..|.|    |..::..:.|||.|      ||.|.|::..
 Frog   381 PMNPA-----IGNGLSPQVMGL----LTNHG----GVPHQPQTDYALSPLTGGLEPPTAVSASCS 432

  Fly   802 SSFSAASSASANVTPHHTIAQESCPSPCSSASHFGVAHSSGFSSDPISPAVSSYAHMSYNYAS 864
            .......|..:..|     :|..||...|         :||:|.:|    |:.|.:..|..::
 Frog   433 QRLEHMKSLDSLST-----SQSYCPPTYS---------TSGYSMEP----VTGYQYPQYGQSA 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	79/120 (66%)
		Homeodomain	473..528	CDD:459649	34/54 (63%)
pax3	XP_012825755.1	PAX	35..162	CDD:238076	81/190 (43%)
		Homeodomain	222..278	CDD:459649	34/55 (62%)
		Pax7	349..393	CDD:403540	15/67 (22%)