DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and toy

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001368990.1	Gene:	toy / 43833	FlyBaseID:	FBgn0019650	Length:	655	Species:	Drosophila melanogaster

Alignment Length:	879	Identity:	313/879 - (35%)
Similarity:	399/879 - (45%)	Gaps:	311/879 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 HPHST---SSYFATTYYHLTDDEC----HSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCD 134
            ||||:   |:.|.          |    |||:||||||:|.||||||||||||||||||||||||
  Fly    12 HPHSSVGQSTLFG----------CSTAGHSGINQLGGVYVNGRPLPDSTRQKIVELAHSGARPCD 66

  Fly   135 ISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRL 199
            |||||||||||||||||||||||||:|||||||||||||..||.||:.|||||||||||||||||
  Fly    67 ISRILQVSNGCVSKILGRYYETGSIKPRAIGGSKPRVATTPVVQKIADYKRECPSIFAWEIRDRL 131

  Fly   200 LQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGS 264
            |.|.||.:|||||||||||||||||:|||||:.
  Fly   132 LSEQVCNSDNIPSVSSINRVLRNLASQKEQQAQ-------------------------------- 164

  Fly   265 RGTLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVG 329
                                           .:.|::|||||:.|.|..
  Fly   165 -------------------------------QQNESVYEKLRMFNGQTG---------------- 182

  Fly   330 QSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASG 394
                                         .|       :|||::             :.||:.:.
  Fly   183 -----------------------------GW-------AWYPSN-------------TTTAHLTL 198

  Fly   395 PSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELD-----GHQS--DETGSGEGENSNGGA 452
            |..|..::.|.::...|.          .:|:. |:||.     .|.:  |.|..|..|:::.|
  Fly   199 PPAASVVTSPANLSGQAD----------RDDVQ-KRELQFSVEVSHTNSHDSTSDGNSEHNSSG- 251

  Fly   453 SNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQV 517
                 .||.|.||.||||||||||||:|:||||||||||||||||||||||||.|||||||||||
  Fly   252 -----DEDSQMRLRLKRKLQRNRTSFSNEQIDSLEKEFERTHYPDVFARERLADKIGLPEARIQV 311

  Fly   518 WFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVST 582
            ||||||||||||||:|.|||       ||.:...|...|..::|          ||:....||:|
  Fly   312 WFSNRRAKWRREEKMRTQRR-------SADTVDGSGRTSTANNP----------SGTTASSSVAT 359

  Fly   583 INGLSSPSTLSTNVN-APTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVG 646
            .|. |:|..:::.:| |....:.:.|:..|            :..||             |..:|
  Fly   360 SNN-STPGIVNSAINVAERTSSALVSNSLP------------EASNG-------------PTVLG 398

  Fly   647 GHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSY----GAVTP---- 703
            |..||.|..|    :...|.|| :|||..||| |..|||::.....:|:::|    |::||
  Fly   399 GEANTTHTSS----ESPPLQPA-APRLPLNSG-FNTMYSSIPQPIATMAENYNSSLGSMTPSCLQ 457

  Fly   704 ----IPSFNH----------------SAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAH 748
                .|...|                :|..|.|.....||.|..|.||           ||..::
  Fly   458 QRDAYPYMFHDPLSLGSPYVSAHHRNTACNPSAAHQQPPQHGVYTNSS-----------PMPSSN 511

  Fly   749 HHIVPGDGGRPAGVGLGSGQSANLGASCSGSGY----EVLSAYALPPPPMASSSAADSSFSAASS 809
            ..::      .|||.:....|....:..:||.|    :..|.:..|...::.::||  :..||.:
  Fly   512 TGVI------SAGVSVPVQISTQNVSDLTGSNYWPRLQXSSIFGSPLDHLSKATAA--AIIAAQA 568

  Fly   810 ASAN---------VTPHHTIAQESCPS-----PCSSASHFGVAHSSGFSSDPI---SPAVSSYAH 857
            |..:         |:.|.|..:::.||     .|.|:.:..:...:|...|.:   ...||...|
  Fly   569 AEKSHKHRKEHSIVSIHTTKRKKNPPSLKRQTTCCSSRYLNMTFGAGKDVDVVIGQGLIVSLTPH 633

  Fly   858 MSYNYASSANTMTPSSASGTSAHVAPGKQQFFAS 891
            :|                        ||.:.|.|
  Fly   634 IS------------------------GKPELFGS 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	109/122 (89%)
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	48/51 (94%)
toy	NP_001368990.1	PAX	29..153	CDD:128645	109/123 (89%)
		COG5576	<253..368	CDD:227863	84/132 (64%)
		Homeobox	269..322	CDD:395001	49/52 (94%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	1	0.900	-	-		E1_KOG0849
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1152885at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45636
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950