DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and sv

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_524633.3	Gene:	sv / 43825	FlyBaseID:	FBgn0005561	Length:	844	Species:	Drosophila melanogaster

Alignment Length:	824	Identity:	234/824 - (28%)
Similarity:	320/824 - (38%)	Gaps:	276/824 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 HSGVNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPR 162
            |.||||||||||.||||||..||:||||||:|.|||||||.|:||:|||||||.|||||||.:..
  Fly   176 HGGVNQLGGVFVNGRPLPDVVRQRIVELAHNGVRPCDISRQLRVSHGCVSKILSRYYETGSFKAG 240

  Fly   163 AIGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQK 227
            .||||||:|||..||..|:.||||.|::||||||||||.|.:|:.||:||||||||::||.||:|
  Fly   241 VIGGSKPKVATPPVVDAIANYKRENPTMFAWEIRDRLLAEAICSQDNVPSVSSINRIVRNKAAEK 305

  Fly   228 ------EQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSES 286
                  .||.                .||.|:||  .::|:.|   :.|||..:....|..|:.|
  Fly   306 AKHVHHHQQH----------------HVSQSLGG--GHIATES---VDSSTGTIGEPQPPTSNSS 349

  Fly   287 GGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQA 351
            ..:.|:                |...:|......|......|..|..|:...|:  :..|.|..|
  Fly   350 ANSVNT----------------NVSASASVHASIPTSGTDSVQVSVGHINANSN--ETTHINSTA 396

  Fly   352 LQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQ 416
            .|:                                 .|.|:              |..:..|.|
  Fly   397 EQR---------------------------------TTGYS--------------INGILGIQH- 413

  Fly   417 RNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTND 481
                             ||.|      ...|:|...:|..|||....|..::...:.:.|:..:|
  Fly   414 -----------------GHHS------HNNNNNSSVNNNNNTESSCKRKRIEAHDENHDTNIHSD 455

  Fly   482 QIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKW--RREEKL------------ 532
            ..|.              .|:|::...| .:....:|    ..||  :.:.||
  Fly   456 NDDG--------------KRQRMSTYSG-DQLYTNIW----SGKWCIKDDHKLLAELGNLTASTG 501

  Fly   533 ---------RNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSS 588
                     .|...|...:|:.||:|... |:.|.||..::|...|.:...|.|||:.|  |..:
  Fly   502 NCPATYYEASNGFSTTPISGSGATASGND-TSMLYDSITTISQTQSSIYTPAIGPSIGT--GSLT 563

  Fly   589 P--------STLSTN----VNAPTLGAGI---------------------------DSSESPTPI 614
            |        ..||.|    ...|.....:                           :||:|.|..
  Fly   564 PLVPISMHEMKLSANSIQEQTVPPFYTALAFDGNYTSMTSLENCSSLVGQEHIVMPESSDSNTLC 628

  Fly   615 P---HIRP------------------SCTSDND------NGRQSEDCRRVCSPCPLGVGGHQNTH 652
            |   .|.|                  .|:.||:      |..||.|  .:.||....:|..|...
  Fly   629 PISTRIVPDITETNSTRVKEPLTNSDGCSEDNNKEPEKSNSSQSSD--HIASPHLHHIGEEQLRG 691

  Fly   653 HIQSNGHAQGH--ALVPAISPR-----LNFNSGSFGAMYSNMHHTALSMSDS---YGAVTPIPSF 707
            :.:||.:|..|  :|:| :.|.     ||.|..      .|.....|::|::   |...|.:|||
  Fly   692 NRRSNLNASTHPSSLIP-LQPSGGSSLLNINPS------ENRSDVELNLSNNVGLYSTPTVLPSF 749

  Fly   708 NHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGLGSGQSANL 772
            ||.:.|          ...:.|.|.|..:         ||:...    ||.....|.|:| |..:
  Fly   750 NHYSAG----------CSSVVPGSDYAYN---------PAYTQY----GGAYGSYGYGTG-SGLI 790

  Fly   773 GASC---SGSGYEVLSAYALPPPPMASSSAADSSFSAASSASAN 813
            .:|.   ||.....|: :.|..|.:|  :.|:|..||||..|.:
  Fly   791 NSSYYYESGQTQSPLT-HDLRSPLVA--TRANSLASAASPGSGS 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	89/122 (73%)
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	9/53 (17%)
sv	NP_524633.3	PAX	175..299	CDD:128645	89/122 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450854
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0849
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840