DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and nkx1.2la

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_997995.2	Gene:	nkx1.2la / 405755	ZFINID:	ZDB-GENE-040615-1	Length:	270	Species:	Danio rerio

Alignment Length:	369	Identity:	84/369 - (22%)
Similarity:	135/369 - (36%)	Gaps:	127/369 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   229 QQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSG 293
            |:|.|.|:|        ..::|.||    .::...::.| |..||:.:      ...:..:.|:|
Zfish     5 QESGGKGTS--------DHRISFSI----IDILDPTKFT-SKKTDVSE------KERTSSSENTG 50

  Fly   294 EGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQ 358
            .||.:|:       .|.:|:.|               .....|.||.      ..|..::.|
Zfish    51 FGSLEES-------RNGKHSDG---------------ECESTGDRSD------DRHGCVRLH--- 84

  Fly   359 SWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVAT 423
              ||                   .|:: .....:|..||....||..|.:..|   .:|..| |.
Zfish    85 --PP-------------------DPDV-DFDCSSSHRSLKSGFSPCEDPDEAA---EERMTP-AP 123

  Fly   424 EDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEK 488
            :|:..::.   .:||.:.:                           |.:|.||:||.:|:.:||.
Zfish   124 DDVSRQRR---RRSDHSCA---------------------------KPRRARTAFTYEQLVALEN 158

  Fly   489 EFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSA 553
            :|..|.|..|..|..||..:.|.|.::::||.|||.||:::             .....||..:.
Zfish   159 KFRATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKKQ-------------NPGVESSLQAG 210

  Fly   554 TASLTDSPNSLSACSSLLSGSAGGPSVSTINGL--SSPSTLSTN 595
            |.||   ||...:|.   |.||..|..||.|.:  |.|..|:::
Zfish   211 TNSL---PNISPSCG---SASALHPPFSTGNMIFHSGPVHLASS 248

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	22/51 (43%)
nkx1.2la	NP_997995.2	Homeobox	145..197	CDD:278475	22/51 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910