DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and phox2a

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_996953.2	Gene:	phox2a / 404602	ZFINID:	ZDB-GENE-000223-14	Length:	280	Species:	Danio rerio

Alignment Length:	323	Identity:	94/323 - (29%)
Similarity:	127/323 - (39%)	Gaps:	119/323 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 TAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQ------------SDETG 441
            :.::|||:.|                     |:||....| ..|..||            ||.:|
Zfish    43 SGFSSGPACA---------------------PLATASCTL-GALREHQPAPYSTVPYKFFSDASG 85

  Fly   442 SGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAG 506
            ..|                       |||.:|.||:||:.|:..||:.|..|||||::.||.||.
Zfish    86 LNE-----------------------KRKQRRIRTTFTSSQLKELERVFAETHYPDIYTREELAL 127

  Fly   507 KIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLL 571
            ||.|.|||:||||.|||||:|::|:..|.:.:.:|.|    ...:.|.:|..|..:..|.||
Zfish   128 KIDLTEARVQVWFQNRRAKFRKQERAANSKASSSSGG----KKPSDARSSSEDDESKESTCS--- 185

  Fly   572 SGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIP---------HIRPSCTSDNDN 627
                  |:..:...:|||              |..||.||:|.|         .|.|:..|
Zfish   186 ------PTPDSTANMSSP--------------GARSSLSPSPAPGPASTFSPASISPALKS---- 226

  Fly   628 GRQSEDCRRVCSPCP-LGVGGHQNTH-HIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMH 688
                       ||.| ||.|....|| |.|.        |:.|..| .:..||.|..:.|:.|
Zfish   227 -----------SPWPSLGSGTPGPTHTHTQE--------LLKAWQP-ADSMSGPFAGVLSSFH 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
phox2a	NP_996953.2	Homeobox	96..148	CDD:306543	32/51 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910