DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and toe

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_524041.2	Gene:	toe / 39418	FlyBaseID:	FBgn0036285	Length:	640	Species:	Drosophila melanogaster

Alignment Length:	784	Identity:	215/784 - (27%)
Similarity:	296/784 - (37%)	Gaps:	267/784 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 LPCLGTAG----------------------GSGLGGIAGKP---SPTMEAVEASTASHPHSTSSY 84
            :|...|||                      ||..||: |:|   :|.......:..:.|||.|.
  Fly    27 IPATATAGSQSPGAIMPMAAVPLPSHLQLLGSSAGGV-GQPAAITPVSPTAATTVLAQPHSLSP- 89

  Fly    85 FATTYYHLTDDECHSGVNQLGGVFVGGRPLPD--------------STRQKIVELAHSGARPCDI 135
             :|..  ||.....:..  |||:|.||.....              :::.:::||:..|.|..|:
  Fly    90 -STPI--LTQGAPPAAA--LGGIFCGGSAAAGPGAAAAAATNLNALASQHRLLELSRFGLRGYDL 149

  Fly   136 SRILQVSNGCVSKILGRYYETGSIRPRA-IGGSKPRVATAEVVSKISQYKRECPSIFAWEIRDRL 199
            ::.:....|.|||:|      |::||.. ||||||:|||..|||||.|||||.|:|||||||:||
  Fly   150 AQHMLSQQGAVSKLL------GTLRPPGLIGGSKPKVATPTVVSKIEQYKRENPTIFAWEIRERL 208

  Fly   200 LQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNVASGS 264
            :.|.||||...||||||||:|||.||::   :....:.:.|.|.:|.              .:..
  Fly   209 ITEGVCTNATAPSVSSINRILRNRAAER---AAAEFARAASYGYAIH--------------PTHP 256

  Fly   265 RGTLSSST----DLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAA 325
            ....|..|    ..:..|.||.:...||.:.:|                       |.|:|..:
  Fly   257 HPYTSFPTWPAHHPLWGAVPLATPPGGGPAGAG-----------------------GALQPGGS- 297

  Fly   326 PLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTA 390
               |.|....|..||:|...:.|......|...       |||....|      |:.....|:.|
  Fly   298 ---GSSYGSDGNMSSNPNSSNSNTTHSNGHNTN-------SGSGCGDS------SAGSGRLSLPA 346

  Fly   391 YASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNI 455
            .:.......|.||..|...:..|                              |||:|.
  Fly   347 LSPDSGSRDSRSPDADANRMIDI------------------------------EGEDSE------ 375

  Fly   456 GNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFS 520
             :.:.||.      |.:||||:|:.:|:|.|||||:::|||.|..||:||.:..|.|||:|||||
  Fly   376 -SQDSDQP------KFRRNRTTFSPEQLDELEKEFDKSHYPCVNTREKLAARTALSEARVQVWFS 433

  Fly   521 NRRAKWRREEK--LRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTI 583
            ||||||||.::  |..||.:|          |||
  Fly   434 NRRAKWRRHQRVNLIKQRDSP----------STS------------------------------- 457

  Fly   584 NGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGH 648
               |||:.|...|.:|.       |..|.|:|...|      ::|:|.:       |.|......
  Fly   458 ---SSPTPLVNPVVSPV-------SPIPVPVPVAVP------ESGQQKQ-------PYPYSTSNM 499

  Fly   649 QNTHHIQSNGHAQGHALVPAISPRLNFNSGS-----FGAMYSNMHHTALSMSDSYGAVTPIPSFN 708
            .||....||.           .|....|.||     ..::.||.|     |.:...||
  Fly   500 CNTSSSSSNS-----------QPCNTINPGSKMSSKTSSVSSNQH-----MEEPAAAV------- 541

  Fly   709 HSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAP-----------AHHHIVPGDGGRPAGV 762
             :...|.| .:|:...|:.:.....|  |||..|...|           |..:|.. ..|.|..:
  Fly   542 -ATASPTA-SAPLSMGGENSAFRALP--MTLPMPMTLPTASAAAFALSFARQYIAK-YMGTPLNL 601

  Fly   763 GLGS 766
            |.||
  Fly   602 GHGS 605

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	61/137 (45%)
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
toe	NP_524041.2	HTH	134..230	CDD:304362	55/101 (54%)
toe	NP_524041.2	Homeobox	388..440	CDD:278475	32/51 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450795
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	1	0.900	-	-		E1_KOG0849
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840