DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and shox2

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_957490.1	Gene:	shox2 / 394171	ZFINID:	ZDB-GENE-040426-1457	Length:	299	Species:	Danio rerio

Alignment Length:	331	Identity:	79/331 - (23%)
Similarity:	129/331 - (38%)	Gaps:	98/331 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   400 SLSPPNDIESLASIGHQ--RNCPVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTE--- 459
            |||...:.|.::||...  |:.||             .::|...|....:|:......|||:
Zfish    39 SLSADPNREEISSITRSGVRSSPV-------------READMLASERSRDSSSPKLTDGNTDMKE 90

  Fly   460 --------DDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQ 516
                    :|:.:..:|::  |:||:||.:|::.||:.|:.|||||.|.||.|:.::||.|||:|
Zfish    91 RKEDCKPLEDETQTKIKQR--RSRTNFTLEQLNELERLFDETHYPDAFMREELSQRLGLSEARVQ 153

  Fly   517 VWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVS 581
            |||.|||||.|::|   ||.......||:                :...||..       .|.|:
Zfish   154 VWFQNRRAKCRKQE---NQLHKGVLIGAA----------------SQFEACRV-------APYVN 192

  Fly   582 TINGLSSPSTLSTNVNAPTLGAGIDSS-ESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGV 645
             :..|..|....::.|.|.....:.:. :..:.:.|..
Zfish   193 -VGALRMPFQQDSHCNVPPFSFQVQAQLQLDSAVAHAH--------------------------- 229

  Fly   646 GGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFN-H 709
                  ||:.|  |...||      |.:.|.:..||...:.:...:.|.:....|.....:.| :
Zfish   230 ------HHLHS--HLAAHA------PYMMFPAPPFGLPLATLAAESASAASVVAAAAAAKTTNKN 280

  Fly   710 SAVGPL 715
            |::..|
Zfish   281 SSIADL 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	31/51 (61%)
shox2	NP_957490.1	Homeobox	111..164	CDD:278475	31/52 (60%)
shox2	NP_957490.1	OAR	278..294	CDD:281777	3/9 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940