DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and gsb-n

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_523862.1	Gene:	gsb-n / 38004	FlyBaseID:	FBgn0001147	Length:	449	Species:	Drosophila melanogaster

Alignment Length:	809	Identity:	183/809 - (22%)
Similarity:	256/809 - (31%)	Gaps:	426/809 - (52%)

- Green bases have known domain annotations that are detailed below.

  Fly   101 VNQLGGVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIG 165
            ||||||||:.|||||:..|.||||:|.||.|||.|||.|:||:|||||||.||.|||||||..||
  Fly    24 VNQLGGVFINGRPLPNHIRLKIVEMAASGVRPCVISRQLRVSHGCVSKILNRYQETGSIRPGVIG 88

  Fly   166 GSKPRVATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQ 230
            ||||:|.:.|:.::|.:.::|.||||:||||::|::|...   :.||.|||:|:||
  Fly    89 GSKPKVTSPEIETRIDELRKENPSIFSWEIREKLIKEGFA---DPPSTSSISRLLR--------- 141

  Fly   231 STGSGSSSTSAGNSISAKVSVSIGGNVSNVASGSRGTLSSSTDLMQTATPLNSSESGGASNSGEG 295
                                                                        .|..|
  Fly   142 ------------------------------------------------------------GSDRG 146

  Fly   296 SEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSW 360
            ||.
  Fly   147 SED-------------------------------------------------------------- 149

  Fly   361 PPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATED 425
                                                                         ..:|
  Fly   150 -------------------------------------------------------------GRKD 153

  Fly   426 IHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEF 490
            ..:...|.|..||                |.:||.:.. :.||||.:|:||:||.:|:::||:.|
  Fly   154 YTINGILGGRDSD----------------ISDTESEPG-IPLKRKQRRSRTTFTAEQLEALERAF 201

  Fly   491 ERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTSATA 555
            .||.||||:.||.||....|.|||||||||||||:.|:.
  Fly   202 SRTQYPDVYTREELAQTTALTEARIQVWFSNRRARLRKH-------------------------- 240

  Fly   556 SLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPS 620
                               :||.:    :|||..::.|:||     |.|:..|.:..|:.:
  Fly   241 -------------------SGGSN----SGLSPMNSGSSNV-----GVGVGLSGATAPLGY---- 273

  Fly   621 CTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFNSGSFGAMYS 685
                                .|||||.            ..|::..|.       .:.:...|..
  Fly   274 --------------------GPLGVGS------------MAGYSPAPG-------TTATGAGMND 299

  Fly   686 NMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHH 750
            .:||.|.:           ||.:|||.                             ...|.||||
  Fly   300 GVHHAAHA-----------PSSHHSAA-----------------------------TAAAAAHHH 324

  Fly   751 IVPGDGGRPAGVGLGSGQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVT 815
            ...|                         ||:::            .|||...|
  Fly   325 TQMG-------------------------GYDLV------------QSAAQHGF----------- 341

  Fly   816 PHHTIAQESCPSPCSSASHFG-------------VAHSSGFSSDPISPAVSSYAHMSYNYA---- 863
                      |...:...|||             :...|..::|.:| .:|...|:|.||:
  Fly   342 ----------PGGFAQPGHFGSQNYYHQDYSKLTIDDFSKLTADSVS-KISPSLHLSDNYSKLEA 395

  Fly   864 -SSANTMTPSSASGTSAHVAPGKQQFFAS 891
             |:.:.....:|:..:||||..:...:|:
  Fly   396 PSNWSQAAYHAAANYNAHVAQHQLNDYAA 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	72/119 (61%)
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
gsb-n	NP_523862.1	PAX	20..141	CDD:278709	72/119 (61%)
gsb-n	NP_523862.1	Homeobox	185..238	CDD:278475	32/52 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450845
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	1	0.900	-	-		E1_KOG0849
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45636
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840