DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and Rx

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	946	Identity:	225/946 - (23%)
Similarity:	335/946 - (35%)	Gaps:	231/946 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PCLGTAGGSGLGGIAGKPSPTMEAVEAS---TASHPHSTSSYFATTYYHLTDDECHSGVNQLGGV 107
            |.|..|.|.. |..||||.....|:..|   ..|...:.::..|.|:.|:.:.     :.|.||
  Fly     9 PALDVAPGQP-GSPAGKPVAISGAMSGSGGVANSSSTAAANNTAATFQHIFEQ-----LVQQGG- 66

  Fly   108 FVGGRPLPD----------------STRQKIVEL--------AHSGARPCDISRILQV--SNGCV 146
              |...||.                ...|.|||.        .|..|...:.:.::..  ||..|
  Fly    67 --GNHKLPPKQLEQLRHLLGNVRDAKNLQMIVEKFKNLEQFHEHYAAHLANNNTVISTEDSNDLV 129

  Fly   147 SKILGRYYETG--SIRPR----AIGGSKPRVATA-------EVVSKISQYKRECPSI---FAWEI 195
             |...|.|.:|  ::.||    ||.|.|.|...|       |.||..|    ..||:   .|.::
  Fly   130 -KDNARKYGSGGQTLTPRHTIDAILGLKNRNGAANGSGRNPETVSDGS----VDPSLGDDDATDL 189

  Fly   196 RDRLLQENVCTNDNIPSVSSINRVLRNLAAQKEQQSTGSGSSSTSAGNSISAKVSVSIGGNVSNV 260
            |..:....:.:.|| ...|.:.:..:|..|......|..|.......|:........:||...:.
  Fly   190 RCGMTLTQLRSMDN-HMASMLQQHAKNGGALPYGPPTPPGGQQPQVPNATPLHHGQQMGGQAGHA 253

  Fly   261 ASGSRGTLSSSTDLMQTATPLNSSESGGASNSGEGSEQEAIYEKLRLLNTQH-----------AA 314
            .....|   ..|.........:::...|....|.|..:||..   ..||:.|           |.
  Fly   254 THAGHG---HPTHHGHAPFGYHNAFGFGQGGHGYGHPEEAAG---NYLNSMHQMVEANQLQTGAN 312

  Fly   315 G----PGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWY----- 370
            |    |.||.|:.    .|....||...::..|.....|....:.......|....|:::
  Fly   313 GANPPPAPLPPSS----FGSHQQHLAALAAQAQEQQNQHSKYAKSSPTGAGPPPPPGAYFMESQT 373

  Fly   371 -PTSLSEI-----PISSAPNI--------------------------------ASVTAYASGPSL 397
             |.:.|:|     .:|||.::                                |.|....:.|.|
  Fly   374 APVAPSQINYDERSMSSASDLEEDDDDAAKLQLDVTSPPTPSPRGQLAAKRKSAGVFCDDNEPKL 438

  Fly   398 AHSLSP-------PNDIESL----ASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGE---NS 448
            |:...|       |..:|.:    .|..||:......:...|::: .|.|.|...||.|.   ||
  Fly   439 ANGQLPGGNYGIRPRSMEEVHHQQQSHHHQQQQQQQQQQQQLQQQ-QGFQHDFRNSGNGNPNGNS 502

  Fly   449 NGG------------------ASN----------------IGNTEDDQARLILKRKLQRNRTSFT 479
            |.|                  ||:                .|:.::.|.....|:|.:||||:||
  Fly   503 NSGDHGERLNADSDSLVNGSCASSEDLNQTNSSEQGEKITSGSDDEGQDDNCAKKKHRRNRTTFT 567

  Fly   480 NDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQR-------R 537
            ..|:..||:.||::|||||::||.||.|:.|||.|:||||.||||||||:||..:.|       :
  Fly   568 TYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLTHFTQ 632

  Fly   538 TPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLST-NVNAPTL 601
            .|:..|..|:........    ||..|||    |.|....|.....:.|:.|.:|:. |:...:|
  Fly   633 LPHRLGCGASGLPVDPWL----SPPLLSA----LPGFLSHPQTVYPSYLTPPLSLAPGNLTMSSL 689

  Fly   602 GA-GIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHAL 665
            .| |...:.:..|.||:     ....:|:....    ..|.|.||.....:||:....|
  Fly   690 AAMGHHHAHNGPPPPHV-----GHGGHGQPQPP----PPPPPHGVPHPHGSHHVVPLSH------ 739

  Fly   666 VPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQGDLTPS 730
               :||.|           |.|...|.|:...:..|||:.:..||::.|.:..:.:......:.|
  Fly   740 ---LSPHL-----------SRMSPHATSLGSPHHGVTPLGTPLHSSLPPSSTATTVAVSSSQSSS 790

  Fly   731 SLYPCHMTLRPPPMAPAHHHIVPGDG---GRPAGVGLGSGQ-SANLGAS---CSGS-GYEVLSAY 787
            |......:.....|:|.:..|...|.   ||.....|.:|. |:|.|:|   |:.| ..|:|...
  Fly   791 SSASLECSGPDVCMSPQNLSIGNADSNGDGRDLSSDLDAGSTSSNPGSSLDKCAASANIELLDVG 855

  Fly   788 ALPPPPMASSSAADSSFSAASSASANVTPHHTIAQE 823
            ...|||..:.:...||.......|.::......|:|
  Fly   856 RDSPPPPPTPTGKGSSTPPTDMRSNSIATLRIKAKE 891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	38/164 (23%)
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	32/51 (63%)
Rx	NP_726006.3	OAR	876..892	CDD:281777	3/16 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	55	1.000	Domainoid score	I4097
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.910