DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ey and Zasp52

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_001027420.2	Gene:	Zasp52 / 36740	FlyBaseID:	FBgn0265991	Length:	2194	Species:	Drosophila melanogaster

Alignment Length:	716	Identity:	142/716 - (19%)
Similarity:	230/716 - (32%)	Gaps:	236/716 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 LSSSTDLMQTATPLNSSESGGASNSGEGSEQEAI--------YEKLRLLNTQHAAGPGPLEPARA 324
            |...||..|   ||...:    .|:|..|||..:        ...:.:.|.:|         ..|
  Fly    23 LQGGTDFAQ---PLLVQK----VNAGSLSEQAGLQPGDAVVKINDVDVFNLRH---------KDA 71

  Fly   325 APLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVT 389
            ..:|.:|.|              |.....|....:|.|       :.|....:|..::|.:.:||
  Fly    72 QDIVVRSGN--------------NFVITVQRGGSTWRP-------HVTPTGNVPQPNSPYLQTVT 115

  Fly   390 AYASGPSLAH-------------------SLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGH 435
            .    .||||                   |......::|:  :..|.|.||            |.
  Fly   116 K----TSLAHKQQDSQHIGCGYNNAARPFSNGGDGGVKSI--VNKQYNTPV------------GI 162

  Fly   436 QSD----ETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSL----EKE--- 489
            .||    ||.|.:.|...||              :|....::|...:..|:.:.|    |:|
  Fly   163 YSDESIAETLSAQAEVLAGG--------------VLGVNFKKNEKEYQGDRSEVLKFLREEETGQ 213

  Fly   490 ----FERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSS 550
                |..:||.....::       |.:.:.|.   |:..:...:::.:.|..|.....|...|..
  Fly   214 STPAFGNSHYEHDAPQQ-------LQQPQQQY---NQHQQHYHQQQQQQQSSTTRHVSAPVNSPK 268

  Fly   551 TSATASLTDSPNSLSACSSLLSG-----------------SAGGPSVSTINGLSSPSTLSTNV-- 596
            ..:|..|....|..:.|..|::|                 :..|.|:......:..:.|..::
  Fly   269 PPSTGGLPTGQNICTECERLITGVFVRIKDKNLHVECFKCATCGTSLKNQGYYNFNNKLYCDIHA 333

  Fly   597 ------NAPTLGAGIDSSESPTPIPHIRPS---CTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTH 652
                  |.||      .:|...|:| |:|:   ..|...:...|.           |.|||
  Fly   334 KQAAINNPPT------GTEGYVPVP-IKPNTKLSASTISSALNSH-----------GYGGH---- 376

  Fly   653 HIQSNGHAQGHALVPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAP 717
               |||::.|:: .||.:|..:..:.:..|..:....||.:     .|.||     .:|....:|
  Fly   377 ---SNGYSNGNS-TPAPAPVASSQATATVATVAPSAATAAT-----AAATP-----QAATATDSP 427

  Fly   718 PSPIPQQGDLT------PSSLY----PCHMTLRPPPMAPAHHHIVPGDGGRP------AGVGLGS 766
            .:......:::      |||:|    ...:.|.|||..|.    ..|.|.:|      .|..:.|
  Fly   428 AATASSSDNMSAYVADEPSSIYGQISAESVALAPPPPQPP----TAGGGDQPFEYVTLTGNVIRS 488

  Fly   767 GQSANLGASCSGSGYEVLSAYALPPPPMASSSAADSSFSAASSASANVTPHHTIAQESCP----- 826
            .|:...||..|   |:|...||.|             |.||:..|....|.....|...|
  Fly   489 VQAPGKGACPS---YKVNQGYARP-------------FGAAAPKSPVSYPPQQQQQSPRPAPGGQ 537

  Fly   827 SPCSSASHFGVAHSSGFSSDPISPAVSS---YAHMSYNYASSANTMTPSSASGT------SAHVA 882
            :|.::.....|....|.:.:.:.|....   | .|....|.:|:..:...:|.|      .:|:|
  Fly   538 NPYATLPRSNVGQQGGEAVEELQPEFEEEDCY-EMDIEVALAASRQSQRGSSFTWPPPQDDSHLA 601

  Fly   883 P 883
            |
  Fly   602 P 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	10/62 (16%)
Zasp52	NP_001027420.2	PDZ_signaling	6..87	CDD:238492	18/93 (19%)
		DUF4749	150..>217	CDD:292558	20/94 (21%)
		LIM_ALP_like	282..333	CDD:188746	6/50 (12%)
		LIM1_Enigma_like_1	2020..2073	CDD:188839
		LIM	2081..2132	CDD:259829
		LIM3_Enigma_like_1	2140..2193	CDD:188845
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030