DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Phox2b

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	XP_008768389.3	Gene:	Phox2b / 364152	RGDID:	1560582	Length:	314	Species:	Rattus norvegicus

Alignment Length:	218	Identity:	71/218 - (32%)
Similarity:	96/218 - (44%)	Gaps:	44/218 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   406 DIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEGENS-----NGGASNIGNTED----- 460
            |..||||         |..|.....:..|.|.:...:..|..|     ..|:.::|...|
  Rat    22 DTSSLAS---------AYADFSSCSQASGFQYNPIRTTFGATSGCPSLTPGSCSLGTLRDHQSSP 77

  Fly   461 ----------DQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARI 515
                      |...|..|||.:|.||:||:.|:..||:.|..|||||::.||.||.||.|.|||:
  Rat    78 YAAVPYKLFTDHGGLNEKRKQRRIRTTFTSAQLKELERVFAETHYPDIYTREELALKIDLTEARV 142

  Fly   516 QVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSST-----SATASLTD---------SPNSLSA 566
            ||||.|||||:|::|:...........|:|...|.:     |..|..||         :||...:
  Rat   143 QVWFQNRRAKFRKQERAAAAAAAAAKNGSSGKKSDSSRDDESKEAKSTDPDSTGGPGPNPNPTPS 207

  Fly   567 CSSLLSGSAGGPSVSTINGLSSP 589
            |.: ..|..||||.:...|.:.|
  Rat   208 CGA-NGGGGGGPSPAGAPGAAGP 229

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
Phox2b	XP_008768389.3	Homeobox	102..155	CDD:395001	32/52 (62%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910