DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and HOXD9

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_055028.3	Gene:	HOXD9 / 3235	HGNCID:	5140	Length:	352	Species:	Homo sapiens

Alignment Length:	279	Identity:	61/279 - (21%)
Similarity:	85/279 - (30%)	Gaps:	95/279 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 GGASNSGEGSEQEAIYEKLRLLNTQHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQA 351
            |||...|.|.                ..|||.          |.||...|.       .:|.|..
Human   128 GGAGGGGGGG----------------GGGPGR----------GPSPGPSGP-------ANGRHYG 159

  Fly   352 LQQHQQQSWPPRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDI----ESLAS 412
            ::                     .|...:.||..|:.|..:|..||:.| |...:.    ||..|
Human   160 IK---------------------PETRAAPAPATAASTTSSSSTSLSSS-SKRTECSVARESQGS 202

  Fly   413 IGHQRNCPVATEDIHLKKELDGHQSDETGSGEG---ENSNGGASNIGNTED-------------- 460
            .|.:.:|.      ...:|.....:..||.|.|   ....||:|......|
Human   203 SGPEFSCN------SFLQEKAAAATGGTGPGAGIGAATGTGGSSEPSACSDHPIPGCSLKEEEKQ 261

  Fly   461 -------------DQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPE 512
                         ..|..|..|..::.|..:|..|...|||||....|.....|..:|..:.|.|
Human   262 HSQPQQQQLDPNNPAANWIHARSTRKKRCPYTKYQTLELEKEFLFNMYLTRDRRYEVARILNLTE 326

  Fly   513 ARIQVWFSNRRAKWRREEK 531
            .::::||.|||.|.::..|
Human   327 RQVKIWFQNRRMKMKKMSK 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	19/51 (37%)
HOXD9	NP_055028.3	Hox9_act	11..>164	CDD:282473	14/89 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..208		28/134 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	229..276		5/46 (11%)
		HOX	285..337	CDD:197696	16/51 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910