DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and HOXB9

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_076922.1	Gene:	HOXB9 / 3219	HGNCID:	5120	Length:	250	Species:	Homo sapiens

Alignment Length:	260	Identity:	60/260 - (23%)
Similarity:	92/260 - (35%)	Gaps:	83/260 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 GTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSLS-------EIPISS----AP----NI 385
            ||.||:      ...::..|:.:..||..:....|.:|..       |.|..|    ||    :.
Human     5 GTLSSY------YVDSIISHESEDAPPAKFPSGQYASSRQPGHAEHLEFPSCSFQPKAPVFGASW 63

  Fly   386 ASVTAYASG--PSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDETGSGEG--- 445
            |.::.:|||  ||:.|....|..:            |.| |..:|:..|:.....|...|:|
Human    64 APLSPHASGSLPSVYHPYIQPQGV------------PPA-ESRYLRTWLEPAPRGEAAPGQGQAA 115

  Fly   446 -----------------------ENSNGGASNIGN-------------TED----DQ----ARLI 466
                                   |.|.|..:.:.|             :||    ||    |..:
Human   116 VKAEPLLGAPGELLKQGTPEYSLETSAGREAVLSNQRPGYGDNKICEGSEDKERPDQTNPSANWL 180

  Fly   467 LKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEK 531
            ..|..::.|..:|..|...|||||....|.....|..:|..:.|.|.::::||.|||.|.::..|
Human   181 HARSSRKKRCPYTKYQTLELEKEFLFNMYLTRDRRHEVARLLNLSERQVKIWFQNRRMKMKKMNK 245

Fly 532 531
Human 246 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	19/51 (37%)
HOXB9	NP_076922.1	Hox9_act	1..172	CDD:282473	36/185 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	21..47		4/25 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..182		6/32 (19%)
		Homeobox	188..241	CDD:278475	19/52 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910