DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and HOXB8

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_076921.1	Gene:	HOXB8 / 3218	HGNCID:	5119	Length:	243	Species:	Homo sapiens

Alignment Length:	180	Identity:	49/180 - (27%)
Similarity:	77/180 - (42%)	Gaps:	39/180 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 GPSLAHSLSPPNDIE-------SLASIGHQRN-CPVATE---------DIHLKKELDGHQSDE-- 439
            |||...|...|:.|:       ||::..:|:| |.||..         |...::.|.|.|..:
Human    41 GPSSGGSFQHPSQIQEFYHGPSSLSTAPYQQNPCAVACHGDPGNFYGYDPLQRQSLFGAQDPDLV 105

  Fly   440 --------TGSGEGENSNGGASNIGNTE-----DDQARLILKRKLQRNRTSFTNDQIDSLEKEFE 491
                    ..||.||.:.|...:...|:     ..||    ....:|.|.:::..|...|||||.
Human   106 QYADCKLAAASGLGEEAEGSEQSPSPTQLFPWMRPQA----AAGRRRGRQTYSRYQTLELEKEFL 166

  Fly   492 RTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNS 541
            ...|.....|..::..:||.|.::::||.|||.||::|   .|:.:.|:|
Human   167 FNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWKKE---NNKDKFPSS 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	18/51 (35%)
HOXB8	NP_076921.1	Antp-type hexapeptide	134..139		0/4 (0%)
		Homeobox	150..203	CDD:395001	19/52 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	203..243		4/14 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R6207
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940