DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and TLX2

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_057254.1	Gene:	TLX2 / 3196	HGNCID:	5057	Length:	284	Species:	Homo sapiens

Alignment Length:	90	Identity:	34/90 - (37%)
Similarity:	47/90 - (52%)	Gaps:	7/90 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   451 GASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARI 515
            |...||:..  |.|...|||  :.||||:..|:..||:.|.|..|.....|..||..:.:.:|::
Human   141 GTRRIGHPY--QNRTPPKRK--KPRTSFSRSQVLELERRFLRQKYLASAERAALAKALRMTDAQV 201

  Fly   516 QVWFSNRRAKWRR---EEKLRNQRR 537
            :.||.|||.||||   ||:...:.|
Human   202 KTWFQNRRTKWRRQTAEEREAERHR 226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	20/51 (39%)
TLX2	NP_057254.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..50
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..106
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..166		12/28 (43%)
		Homeobox	160..213	CDD:278475	20/52 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910