DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and Pax1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	XP_038960976.1	Gene:	Pax1 / 311505	RGDID:	1588548	Length:	449	Species:	Rattus norvegicus

Alignment Length:	398	Identity:	148/398 - (37%)
Similarity:	181/398 - (45%)	Gaps:	128/398 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RNLP-CLGTAGGS-GLGGIAGKPSPTMEAVEASTASHPHSTSSYFATTYYHLTDDECHSGVNQLG 105
            |.|| ||...||: .|...|| |||....  |...:.|.:.             ::.:..|||||
  Rat    50 RALPLCLSGGGGARALPDCAG-PSPRRSG--ARQLAGPRAM-------------EQTYGEVNQLG 98

  Fly   106 GVFVGGRPLPDSTRQKIVELAHSGARPCDISRILQVSNGCVSKILGRYYETGSIRPRAIGGSKPR 170
            ||||.|||||::.|.:|||||..|.|||||||.|:||:|||||||.||.|||||.|.||||||||
  Rat    99 GVFVNGRPLPNAIRLRIVELAQLGIRPCDISRQLRVSHGCVSKILARYNETGSILPGAIGGSKPR 163

  Fly   171 VATAEVVSKISQYKRECPSIFAWEIRDRLLQENVCTNDNIPSVSSINRVLRN----LA------A 225
            |.|..||..|..||:..|.|||||||||||.:.||...|:||||||:|:|||    ||      |
  Rat   164 VTTPNVVKHIRDYKQGDPGIFAWEIRDRLLADGVCDKYNVPSVSSISRILRNKIGSLAQPGPYEA 228

  Fly   226 QKEQ--------------------QSTGSGSSS-----TSAGNSISAKVSVSIGGNVSNV----- 260
            .|:.                    ..||:...|     .|||: :|...|.....:|||:
  Rat   229 SKQPPPQPALPYNHIYQYPYPSPVSPTGTKMGSHPGVPGSAGH-VSIPRSWPSAHSVSNILGIRT 292

  Fly   261 -----------------------ASGSRGTLSSST------------DLMQTATPLNSSESGG-- 288
                                   ||.:|...|:|:            |:..|.:..:.|..||
  Rat   293 FMEQTGALAGSEGAAYSPKVEDWASVNRAAFSTSSAVNGLEKPALEADIKYTQSASSLSAVGGFL 357

  Fly   289 ------ASNSGEGSEQEAIYEKLRLLNTQHAAG---PG-PLEPARAAPLVGQSPNHLGTRSSHPQ 343
                  |||      |..:|       :..|||   || |..||:|.||   :|:..|.
  Rat   358 PACAYPASN------QHGVY-------SAPAAGYLSPGPPWPPAQAPPL---APHGAGV------ 400

  Fly   344 LVHGNHQA 351
            .|||...|
  Rat   401 AVHGGELA 408

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645	83/122 (68%)
ey	NP_001014693.1	Homeobox	475..527	CDD:278475
Pax1	XP_038960976.1	PAX	90..217	CDD:238076	86/126 (68%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910