DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and vsx1

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_571408.1	Gene:	vsx1 / 30598	ZFINID:	ZDB-GENE-990415-205	Length:	344	Species:	Danio rerio

Alignment Length:	409	Identity:	121/409 - (29%)
Similarity:	159/409 - (38%)	Gaps:	129/409 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 KVSVSIGGNVSNV-ASGSRGTLSSSTDLMQTATPLNSSESG-GASNSGEGSEQEAIYEKLRLLNT 310
            |:..|.|.:.|.: .||.|....:.|||:...:.|...:|| ||..:|||
Zfish    15 KLYPSFGIDKSRLNGSGFRSKGFAITDLLGLESELQPHQSGPGAGPNGEG--------------- 64

  Fly   311 QHAAGPGPLEPARAAPLVGQSPNHLGTRSSHPQLVHGNHQALQQHQQQSWPPRHYSGSWYPTSL- 374
            |.||..|...|..:.||      .||...|         .|.||      ||    |:  |..|
Zfish    65 QSAAVGGFSFPGGSLPL------GLGFLCS---------LAAQQ------PP----GA--PCFLP 102

  Fly   375 SEIPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNCPVATEDIHLKKELDGHQSDE 439
            |.||:                           ::|.......:|         |:::.|.:..|:
Zfish   103 SHIPL---------------------------LQSRTESHFMQN---------LEQQRDVYSDDD 131

  Fly   440 TGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERL 504
            ..||:   .|.| .|.||::        |||.:|:||.||:.|::.|||.|...|||||:|||.|
Zfish   132 CLSGD---RNDG-KNSGNSQ--------KRKKRRHRTVFTSHQLEELEKAFNEAHYPDVYAREML 184

  Fly   505 AGKIGLPEARIQVWFSNRRAKWRREEK-----------------LRNQRRTPNSTGASATSSSTS 552
            |.|..|||.||||||.|||||||:.||                 :|:....|.|...||.|....
Zfish   185 AMKTELPEDRIQVWFQNRRAKWRKREKCWGRSSVMAEYGLYGAMVRHSIPLPESIINSAKSGMMG 249

  Fly   553 ATAS-LTDSPNSLSACSSLLSGSAGGPSVSTIN--------GLSSPSTLSTNVNAPTLGAGIDSS 608
            :.|. |...|..:...|..:...|.|...||.:        |..|.:|.|:..|      |.|.|
Zfish   250 SCAPWLLGEPAGMHKKSMEIVKKAPGTPESTHSDTYSEEHKGKDSDTTWSSGAN------GADDS 308

  Fly   609 ESPTPIPHIRPSCTSDNDN 627
            |...    |..|.||..:|
Zfish   309 EDMA----IDLSSTSKQEN 323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	34/51 (67%)
vsx1	NP_571408.1	Octapeptide motif	37..44		3/6 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	49..70		11/35 (31%)
		COG5576	101..>221	CDD:227863	58/167 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	127..156		12/40 (30%)
		Nuclear localization signal. /evidence=ECO:0000269\|PubMed:11331779	147..151		2/11 (18%)
		Homeobox	154..207	CDD:278475	34/52 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..344		18/61 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910