DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and dlx3b

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_571397.2	Gene:	dlx3b / 30585	ZFINID:	ZDB-GENE-980526-280	Length:	269	Species:	Danio rerio

Alignment Length:	333	Identity:	72/333 - (21%)
Similarity:	118/333 - (35%)	Gaps:	97/333 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   366 SGSWYPTSLSE--IPISSAPNIASVTAYASGPSLAHSLSPPNDIESLASIGHQRNC--------- 419
            |.|.:|||...  :|.|||.::.   .|:|......|...|..:.|.    ||.|.
Zfish    20 SMSCHPTSKDSPTLPESSATDMG---YYSSHHEYYQSPPYPQQMNSY----HQFNLSGMGATPGA 77

  Fly   420 -PVATEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLI--LKRKLQRNRTSFTND 481
             |..||..:......||.:.:.       .....|.:....:.:.|::  ..:|:::.||.:::.
Zfish    78 YPTKTEYPYNTYRQYGHYNRDL-------QTPPQSAVKEEPETEVRMVNGKPKKIRKPRTIYSSY 135

  Fly   482 QIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASA 546
            |:.:|::.|::..|..:..|..||.::||.:.::::||.|||:|::   ||......|
Zfish   136 QLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFK---KLYKNGEVP------- 190

  Fly   547 TSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESP 611
                      |..|||   |..|:...|...|:|...|..||.               ::..:.|
Zfish   191 ----------LEHSPN---ASDSMACNSPPSPAVWDNNAHSSQ---------------VNRGQIP 227

  Fly   612 TPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNTHHIQSNGHAQGHALVPAISPRLNFN 676
            .|.....|....|..|                        |..|...|.| |.:.....|:
Zfish   228 QPPLSSTPPYMEDYSN------------------------HWYQQGSHLQ-HPVHHPGPPQ---- 263

  Fly   677 SGSFGAMY 684
              |.||:|
Zfish   264 --SVGAVY 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	17/51 (33%)
dlx3b	NP_571397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		9/20 (45%)
		DLL_N	28..104	CDD:289198	17/89 (19%)
		Homeobox	128..181	CDD:278475	17/52 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..242		16/68 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..269		7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910