DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and otx2b

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_571326.1	Gene:	otx2b / 30501	ZFINID:	ZDB-GENE-980526-406	Length:	289	Species:	Danio rerio

Alignment Length:	335	Identity:	88/335 - (26%)
Similarity:	130/335 - (38%)	Gaps:	123/335 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 RKLQRNRTSFTNDQIDSLEKEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREE--- 530
            ||.:|.||:||..|:|.||..|.:|.|||:|.||.:|.||.|||:|:||||.|||||.|:::
Zfish    36 RKQRRERTTFTRAQLDVLEALFAKTRYPDIFMREEVALKINLPESRVQVWFKNRRAKCRQQQQQQ 100

  Fly   531 ------KLRNQRRTPNSTGASATSSSTSATASLTDSPNSLSACSSLLSGSAGGPSVSTIN---GL 586
                  |:|..::  .|:.|...||.:.|:...| .|:|.|.           |::||..   .:
Zfish   101 QNGGQNKVRPAKK--KSSPAREASSESGASGQFT-PPSSTSV-----------PAISTTTAPVSI 151

  Fly   587 SSPSTLSTNVNAPTLGAGIDSSESPTPIPHIRPSCTSDNDNGRQSEDCRRVCSPCPLGVGGHQNT 651
            .||:::|                     |...|..||.:        |.:...|..
Zfish   152 WSPASIS---------------------PLSDPLSTSSS--------CMQRSYPMT--------- 178

  Fly   652 HHIQSNGHAQGHALVPAISPRLNFNSGS---FGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVG 713
             :.|::|::||:|             ||   ||.|            |....:||:   :|...|
Zfish   179 -YTQASGYSQGYA-------------GSTSYFGGM------------DCGSYLTPM---HHQLTG 214

  Fly   714 PLAPPSPIPQQGDLTPSSLYPCHMTLRPPPMAPAHHHIVPGDGGRPAGVGL------------GS 766
            |.:..||:       .|:....|:...|..:        |..|...:|:|.            .|
Zfish   215 PGSTLSPM-------SSNAVTSHLNQSPASL--------PTQGYGASGLGFNSTADCLDYKDQAS 264

  Fly   767 GQSANLGASC 776
            ....|..|.|
Zfish   265 SWKLNFNADC 274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	32/51 (63%)
otx2b	NP_571326.1	Homeobox	42..94	CDD:395001	32/51 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..142		13/62 (21%)
		TF_Otx	155..234	CDD:397546	27/152 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000011
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910