DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ey and hoxd3a

DIOPT Version :9

Sequence 1:	NP_001014693.1	Gene:	ey / 43812	FlyBaseID:	FBgn0005558	Length:	898	Species:	Drosophila melanogaster
Sequence 2:	NP_571200.1	Gene:	hoxd3a / 30349	ZFINID:	ZDB-GENE-990415-120	Length:	396	Species:	Danio rerio

Alignment Length:	394	Identity:	93/394 - (23%)
Similarity:	145/394 - (36%)	Gaps:	113/394 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   362 PRHYSGSWYPTSLSEIPISSAPNIASVTAYASGPSLAHSLSPPNDI----ESLASIGHQRNCPVA 422
            |....|:..|.|:||             ...:.|..|.|.||..:.    :|.:|.|.....||
Zfish    71 PSASQGNSQPESISE-------------QQQAAPLAASSPSPSTNSTQKKKSPSSNGSSTATPV- 121

  Fly   423 TEDIHLKKELDGHQSDETGSGEGENSNGGASNIGNTEDDQARLILKRKLQRNRTSFTNDQIDSLE 487
                 :.|::.....:...:.:.:::|..|:  |.|.||::......|  |.||::|:.|:..||
Zfish   122 -----ISKQIFPWMKETRQNAKQKSTNCPAA--GETCDDKSPPGPASK--RVRTAYTSAQLVELE 177

  Fly   488 KEFERTHYPDVFARERLAGKIGLPEARIQVWFSNRRAKWRREEKLRNQRRTPNSTGASATSSSTS 552
            |||....|.....|..:|..:.|.|.:|::||.|||.|:::::|.:....:|
Zfish   178 KEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKDQKSKGIMHSP------------- 229

  Fly   553 ATASLTDSPNSLSACSSLLSGSAGGPSVSTINGLSSPSTLSTNVNAPTLGAGIDSSESPTPIPHI 617
                |..||:.    |..||||         |.:.....| .|||:.       |.::|:|....
Zfish   230 ----LGHSPDR----SPPLSGS---------NHIGYSGQL-PNVNSL-------SYDAPSPPSFA 269

  Fly   618 RPSCTSDNDNGRQSEDCRRVCSPCPLG---------VGGHQNTHHIQSNG------------HAQ 661
            :|          |...........|||         .|...:.|.:|.||            :..
Zfish   270 KP----------QQNIYGLAAYTAPLGGCIPQQKRYPGTEYDHHSMQGNGSFANANLQSSPVYVG 324

  Fly   662 GHAL--VPAISPRLNFNSGSFGAMYSNMHHTALSMSDSYGAVTPIPSFNHSAVGPLAPPSPIPQQ 724
            |:.:  :||..|.  ||.|       ::.|.: |.|..|.....||..:|.     .|..|.|..
Zfish   325 GNFVDSMPASGPM--FNLG-------HLPHPS-SASVDYSCAAQIPGNHHH-----GPCDPHPTY 374

  Fly   725 GDLT 728
            .||:
Zfish   375 TDLS 378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ey	NP_001014693.1	PAX	98..221	CDD:128645
ey	NP_001014693.1	Homeobox	475..527	CDD:278475	21/51 (41%)
hoxd3a	NP_571200.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..163		24/114 (21%)
		Abdominal-A	116..237	CDD:332641	37/151 (25%)
		Antp-type hexapeptide	126..131		0/4 (0%)
		Homeobox	165..217	CDD:306543	21/51 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..246		11/56 (20%)
		DUF4074	333..394	CDD:315871	17/61 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	364..396		6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910